Head-out immersion in hot water does not increase serum CXCL1 in healthy men

Yuta Sakurai, Yasunori Umemoto, Takashi Kawasaki, Daisuke Kojima, Tokio Kinoshita, Mami Yamashiro, Motohiko Banno, Hideki Arakawa, Fumihiro Tajima

Article ID: 37
Vol 3, Issue 1, 2019


Abstract


Exercise-induced production of interleukin (IL)-6 results in the expression of chemokine CXC-motif ligand 1 (CXCL1) in mice. Recent studies described the increase in serum IL-6 levels during immersion of subjects in hot water. The present study investigated the effects of a 20-min head-out water immersion in 42 °C water (hot-HOI) on serum concentrations of CXCL1 in eight healthy men. Venous blood samples were taken at rest, immediately after hot-HOI, as well as 1, 2, 3, and 4 h after hot-HOI for measurements of serum concentrations of CXCL1, IL-6, tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hsCRP), while assessing counts of blood cells (CBC) and monitoring core temperature (Tcore). Tcore and serum IL-6 increased during hot-HOI and remained high until 4 h after hot-HOI. However, serum CXCL1, TNF-α, hsCRP, and CBC remained constant throughout the experiment. In conclusion, the results from our study demonstrated that 20-min hot-HOI increased serum IL-6, but not CXCL1 in healthy man.

Keywords


IL-6; TNF-α; hsCRP; hyperthermia; myokine

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DOI: https://doi.org/10.24294/ti.v3.i1.37

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