Evaluation of the safety and usefulness of citrus jabara fruit peel powder cream for patients with atopic dermatitis

Yutaka Inaba, Fukumi Furukawa, Seisho Azuma, Kimiye Baba, Masahiko Taniguchi, Yoshinobu Murakami

Article ID: 1230
Vol 4, Issue 1, 2020

VIEWS - 988 (Abstract) 506 (PDF)

Abstract


Citrus jabara (CJ) is a rare citrus that originally grew wild only in the southern area of the Kii peninsula in Japan. In the relationship between CJ and atopic dermatitis (AD), improvement of AD by oral intake of CJ fruit juice was reported in AD model mice. Our previous study also showed anti-inflammatory potentials of CJ fruit peels in vitro. In this study, the applicability of CJ fruit peel powder (CJ powder) for topical application in patients with AD was investigated. After confirming both the safety of CJ powder in preclinical studies and the safety of 5% CJ powder cream in healthy volunteers, the safety and usefulness of 5% CJ powder cream were evaluated in 20 patients with AD. Evaluation of 5% CJ powder cream in patients with AD for 4 weeks showed improvement in the mean severity score of the affected area (from 3.0 to 2.0, p=0.001 by Student’s t test), improvement in skin lesions (11 of 20 participants), usefulness (16 of 20 participants), and safety (16 of 20 participants). Although aggravation of symptoms on application areas were observed on 4 participants, their aggravation were systemic, resulting from causes other than tested cream. These results suggested that 5% CJ powder cream is useful and safe for patients with AD.

Keywords


Citrus jabara; Atopic Dermatitis; External Cream; Narirutin; Safety; Usefulness

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References


1. Azuma S, Murakami Y, Azuma A, et al. Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels. Trends in Immunother 2018; 2(2). doi: 10.24294/ti.v2i2.844.

2. Funaguchi N, Oono Y, Minatoguchi K, et al. Oral administration of “Jabara” juice inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. Clin Immunol Allergol 2014; 62(4): 455–458.

3. JP Patent No. 5,323,127.

4. Saeki H, Furue M, Furukawa F, et al. COMMITTEE for GUIDELINES for the MANAGEMENT of ATOPIC DERMATITIS of JAPANESE DERMATOLOGICAL ASSOCIATION. Guidelines for management of atopic dermatitis. J Dermatol. 2009; 36(10): 563–577. doi: 10.1111/j.1346-8138.2009. 00706.x.

5. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014; 63(4): 575–585. doi: 10.2332/allergolint.13-OA-0683.

6. Kanehara S, Ohtani T, Uede K, et al. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. J Dermatol. 2007; 34(12): 811–815. doi: 10.1111/j.1346-8138.2007.00 391.x.

7. Karlberg AT, Magnusson K, Nilsson U. Air oxidation of d-limonene (the citrus solvent) creates potent allergens. Contact Derm 1992; 26(5): 332–340. doi: 10.1111/j.1600-0536.1992.tb00129.x

8. J Sun H, Ni H, Chen F, et al. Effect of oxygen and heating on aromas of pummelo (Citrus maxima) essential oil. J Essent Oil Res 2018; 30(2): 1–13. doi: 10.1080/10412905.2017.1420553

9. Messer A, Raquet N, Lohr C, et al. Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity. Food Chem Toxicol 2012; 50(3–4): 756–760. doi: 10.1016/j.fct.2011.11. 023.

10. Fujita T, Kawase A, Niwa T, et al. Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities. Biol Pharm Bull 2008; 31(5): 925-930. doi: 10.1248/bpb.31.925.

11. Funaguchi N, Oono Y, La BL, et al. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol Physiol. 2007 34 (8): 766–770. doi: 10.1111/j.1440-1681.2007.0463 6.x.

12. Minatoguchi K, Oono Y, Funaguchi N. Effect of “Jabara” juice on symptoms and QOL in patients with Japanese cedar pollinosis. Clin Immunol Allergol 2008–2009; 50 (3): 360–364.




DOI: https://doi.org/10.24294/ti.v4.i1.1230

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