Synthesis and in Vitro anticancer properties of Cu2–xSe–AIPH nanomaterials

Juan Lu, Yini Mao, Jun Yang

Article ID: 1408
Vol 5, Issue 1, 2022, Article identifier:10-18

VIEWS - 32 (Abstract) 22 (PDF)

Abstract


The Cu2–xSe nanoparticles were synthesized by high temperature pyrolysis, modified with aminated polyethylene glycol in aqueous solution and loaded with compound 2,2′–azobis[2–(2–imidazolin–2–yl)propane] dihydrochloride (AIPH). The obtained nanomaterials can induce photothermal effect and use heat to promote the generation of toxic AIPH radicals under the irradiation of near-infrared laser (808 nm), which can effectively kill cancer cells. A series of in vitro experiments can preliminarily prove that Cu2–xSe–AIPH nanomaterials have strong photothermal conversion ability, good biocompatibility and anticancer properties.


Keywords


Cu2–xSe Nanoparticles; AIPH; Photothermal Effect; Anticancer Properties

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References


Sun Y, Zhou Q, Su S. Research progress of Chinese medicine compatibility in cancer treatment (in Chinese). World Journal of Integrated Traditional and Western Medicine 2015; 10(10): 1476–1480.

Chen W, Liu Y, Wang S, et al. Research progress in co-delivery of gene and chemotherapy drugs with cationic liposome carrier for cancer therapy. Acta Pharmaceutica Sinica 2012; 47(8): 986–992.

Jiang Y, Liu S, Zhang Y, et al. Magnetic mesoporous nanospheres anchored with LyP–1 as an efficient pancreatic cancer probe. Biomaterials 2017; 115: 9–18.

Liu J, Yang Y, Zhu W, et al. Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment. Biomaterials 2016; 97: 1–9.

Zhao T, Wang P, Li Q, et al. Near-infrared triggered decomposition of nanocapsules with high tumor accumulation and stimuli responsive fast elimination. Angewandte Chemie International Edition 2018; 57(10): 2611–2615.

Zhao C, Li W. Progress in inorganic nanomaterials for photothermal therapy of cancer. Tumor 2017; 37(3): 289–294.

Zhang X, Li W. Progress in nanomaterials for photothermal therapy in cancer. Chinese Journal of Pharmaceuticals 2016; 47(8): 1065–1069.

Zhao M, Ding J, Mao Q, et al. A novel αvβ3 integrin-targeted NIR–II nanoprobe for multimodal imaging-guided photothermal therapy of tumors in vivo. Nanoscale 2020; 12(13): 6953–6958.

Feng F, Feng J, Wu C, et al. Chemical synthesis and assembly of quasi-two-dimensional metal chalcogenides graphene analogues. Scientia Sinica (Chimica) 2012; 42(11): 1575–1585.

Rui X, Yao X, An L, et al. Recent advances of theranotics agents based on copper chalcogenide. Journal of Shanghai Normal University (Natural Sciences) 2016; 45(6): 748–756.

Cai X, Shang Y, Wang C. Application of mesoporous nano-silica as drug carrier in cancer therapy. Chinese Journal of Biochemistry and Molecular Biology 2019; 35(3): 274–279.

Jiang W, Chen J, Gong C, et al. Intravenous delivery of enzalutamide based on high drug loading multifunctional graphene oxide nano-particles for castration-resistant prostate cancer therapy. Journal of Nanobiotechnology 2020; 18(1): 50.

Liu Y, Zhu D, Hu Y, et al. Controlled synthesis of Cu2–xSe nanoparticles as near-infrared photothermal agents and irradiation wave-length dependence of their photothermal conversion efficiency. Langmuir 2018; 34(46): 13905–13909.

Yan Y, Qian X, Yin J, et al. Preparation and characterization of Cu2–xSe nanocrystals by trisodium citrate-assisted photochemical route. Chinese Journal of Inorganic Chemistry 2003; (10): 1133–1136.

Tao C, Yang G, Yang S. The research progress in Fe@Fe3O4 based diagnosis and treatment platform. Journal of Shanghai Normal University (Natural Sciences) 2019; 48(4): 449–459.

Jiao T, Huang X, Zhang L, et al. Research progress on syntheses of nanomaterials based on photothermal agent/photosensitizer and applications. Journal of Yanshan University 2017; 41(3): 189–203.

Jiang X, Zhang S, Ren F, et al. Ultrasmall magnetic CuFeSe2 ternary nanocrystals for multimodal imaging guided photothermal therapy of cancer. ACS Nano 2017; 11(6): 5633–5645.

Zhu Y, Huang K, Wang Y, et al. Advance on HDAC multi-target inhibitors in the treatment of cancer. Journal of Liaocheng University (Natural Science Edition) 2019; 32(5): 71–79.

Ming C, Chen H, Pei M. Researches on luminescent thermal properties of Er3+/Yb3+-doped YAG crystal for optical temperature sensor. Journal of Liaocheng University (Natural Science Edition) 2020; 33(2): 73–77.

Pan W, Dai C, Li Y, et al. PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis. Biomaraterials 2020; 239: 119851.

Li G, Wang Q, Liu Z, et al. Research progress of photodynamic active platinum (Ⅳ) complexes as antitumor drugs. Journal of Liaocheng University (Natural Science Edition) 2018; 31(2): 21–32.

Zhou A. Advances in biopharmaceuticals and biosimilars. Chinese Journal of New Drugs 2017; 26(3): 296–299.

Fang Q. Photodynamic therapy for cancer treatment and the new antitumor photosensitizer sinoporphyrin sodium. Chinese Journal of New Drugs 2014; 23(13): 1540–1545.

Qin Y, Han Y, Jin H, et al. Drug-loaded copper sulfide nanoparticles with high photothermal conversion and pH-stimuli response for drug delivery. Chinese Science Bulletin 2020; 65(Z1): 203–212.

Liu H, Yang Q, Guo W, et al. CoWO4–x-based nanoplatform for multimode imaging and enhanced photothermal/photodynamic therapy. Chemical Engineering Journal 2020; 385: 123979.

Li J, Peng Q, Wang L, et al. pH- and NIR laser dual-responsive metal-organic frameworks ZIF–8 with MoS2 nanosheets and DOX loading for chemo/photothermal synergistic cancer therapy. Acta Laser Biology Sinica 2019; 28(5): 421–430.




DOI: http://dx.doi.org/10.24294/can.v5i1.1408

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