Transient effectiveness of dapsone for skin lesions in a patient with discoid lupus erythematosus

Naoya Mikita, Fukumi Furukawa


Dapsone is a synthetic sulfone preparation and is second-line treatment for cutaneous lupus erythematosus (CLE) including discoid LE (DLE). This report describes a patient with DLE, which was improved by dapsone quickly but the recurrence was noted.  Oral administration of prednisolone (5 mg / day) was required but the complete healing was very difficult. In this report, we will discuss the effectiveness and limitation of dapsone   for patients with DLE and the mechanisms of action.


dapsone; diaminodiphenyl sulfone; DDS; discoid lupus erythematosus

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