Pyoderma gangrenosum: A single-center case series study of 32 cases

Malik Güngör, Gülbin Yaşar Subaşı, Aslı Bilgiç, Ayşe Akman, Ertan Yılmaz, Erkan Alpsoy

Article ID: 2415
Vol 7, Issue 2, 2023

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Abstract


Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with multiple different clinical presentations and associated comorbidities. It often presents as ulcerated lesions with a violet/erythematous border and an irregular undercut margin. In this largest single-centre case series study in Antalya-Turkey, we reviewed 32 PG patients diagnosed consecutively within the last 5-year period. Consistent with the literature, PG morphologically often presented with the ulcerative clinic (90.6%), and inflammatory bowel disease (15.6%) was the most common etiologic factor. In our study, female gender predominance (78.2%), lower extremity localization (93.7%), and the rate of multiple ulcers at diagnosis (90.6%) were more prominent than in the literature. Unlike the literature, oral mucosa involvement and syndromic form (both, 6.2%) of the disease were detected more frequently. Our results indicate that PG patients may show differences according to geographical and ethnic differences and/or characteristics of the healthcare institution.


Keywords


pyoderma gangrenosum; case series; neutrophilic dermatosis

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References


1. Maverakis E, Marzano AV, Le ST, et al. Pyoderma gangrenosum. Nature Reviews Disease Primers 2020; 6(1): 81. doi: 10.1038/s41572-020-0213-x

2. Marzano AV, Trevisan V, Galloni C, Alessi E. Fatal bullous pyoderma gangrenosum in a patient with Klinefelter’s syndrome. Acta Dermato-Venereologica 2008; 88(2): 158–159. doi: 10.2340/00015555-0346

3. Kridin K, Cohen AD, Amber KT. Underlying systemic diseases in pyoderma gangrenosum: A systematic review and meta-analysis. American Journal of Clinical Dermatology 2018; 19(4): 479–487. doi: 10.1007/s40257-018-0356-7

4. Serdar Aşiran Z, Yaşar Ş, Güneş P. Pyoderma gangrenosum: Retrospective evaluation of 20 cases. Turkderm-Turk Arch Dermatol Venereol 2011; 45(2): 83–87. doi: 10.4274/turkderm.45.19

5. Duman N, Ersoy Evans S. Pyoderma gangrenosum: A retrospective study of 25 cases and review of literature findings. Turkiye Klinikleri Journal of Dermatology 2013; 23(3): 77–83.

6. Adisen E, Erduran F, Gürer MA. Pyoderma gangrenosum: A report of 27 patients. The International Journal of Lower Extremity Wounds 2016; 15(2): 148–154. doi: 10.1177/1534734616639172

7. Binus AM, Qureshi AA, Li VW, Winterfield LS. Pyoderma gangrenosum: A retrospective review of patient characteristics, comorbidities and therapy in 103 patients. British Journal of Dermatology 2011; 165(6): 1244–1250. doi: 10.1111/j.1365-2133.2011.10565.x

8. Kim YJ, Lee KH, Won CH, et al. Clinicopathological features and prognosis of pyoderma gangrenosum in Korea: A single-centre, retrospective, 20-year observational study. Indian Journal of Dermatology, Venereology and Leprology 2023; 89(1): 25–34. doi: 10.25259/IJDVL_968_20




DOI: https://doi.org/10.24294/ti.v7.i2.2415

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