Therapeutic effects of cyclosporine on Hailey-Hailey disease

Aika Okuno, Yuki Kanda, Hajime Nakano, Nobuo Kanazawa, Fukumi Furukawa

Article ID: 1140
Vol 3, Issue 1, 2019

VIEWS - 721 (Abstract) 437 (PDF)

Abstract


Hailey-Hailey disease is an autosomal dominant hereditary skin disease. Severe cases are often difficult to treat. We report a recent case that was successfully treated using cyclosporine. The case is described from the aspects of treatment and gene mutation.


Keywords


Hailey-Hailey disease; cyclosporine; ATP2C1; treatment

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References


1. Hu Z, Bonifas JM, Beech J, et al. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat Genet 2000; 24: 61-65. doi: 10.1038/71701

2. Yasuda H, Kanazawa N, Matsuda M, et al. A case of Hailey-Hailey disease with a novel nonsense mutation in the ATP2C1 gene. Ann Dermatol. 2017; 29: 642-644. doi: 10.5021/ad.2017.29.5.642.

3. Dobson-Stone C, Fairclough R, Dunne E, et al. Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene. J Invest Dermatol 2002; 118: 338-343. doi: 10.1046/j.0022-202x.2001.01675.x

4. Koeyers WJ, Van Der Geer S, Krekels G. Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease. J Dermatolog Treat. 2008; 19: 251-254. doi: 10.1080/09546630801955135.

5. Hurd DS, Johnston C, Bevins A. A case report of Hailey-Hailey disease treated with alefacept (Amevive). Br J Dermatol. 2008; 158: 399-401. doi: 10.1111/j.1365-2133.2007.08248.x

6. Ichikawa Y, Nakano H, Ansai S et al. Case of Hailey-Hailey disease with a novel missense/in‐frame deletion mutation in ATP 2C1 successfully treated with cyclosporine. J Dermatol 2019; doi: 10.1111/1346-8138.15081

7. Soleymani T, Vassantachart JM, Wu JJ. Comparison of guidelines for the use of cyclosporine for psoriasis: a critical appraisal and comprehensive review. J Drugs Dermatol. 2016 15(3):293-301. PMID: 26954314

8. Hashizume H, Kageyama R, Umayahara T, et al. A case of pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome successfully treated with combination therapy of corticosteroids, cyclosporine, and colchicine. Trends Immunother 2018; doi: 10.24294/ti.v2.i2.719

9. Kanauchi H, Takigawa M, Imamura S, et al. Effects of cyclosporin A on lupus dermatoses in autoimmune prone MRL/Mp-lpr/lpr mice. J Dermatol Treat 1994; 5: 187–191. https://doi.org/10.3109/09546639409080564

10. Mayuzumi N, Ikeda S, Kawada H, et al. Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes. Br J Dermatol 2005; 152: 920-924. doi: 10.1111/j.1365-2133.2005.06394.x

11. Kobayashi D, Ohkubo S, Nakahata N. Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes. Eur J Pharmacol 2007; 573: 249– 252. doi: 10.1016/j.ejphar.2007.07.058




DOI: https://doi.org/10.24294/ti.v3.i1.1140

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