Discontinuing voriconazole induced no completely regression of multiple cutaneous squamous cell carcinoma in a hematopoietic stem cell transplant patient

Yuka Hirakawa, Aika Okuno, Atsuko Tanabe, Mutsumi Okada, Naoyuki Anzai, Yuki Yamamoto, Fukumi Furukawa


Voriconazole is a universal anti-fungal prophylaxis, which is frequently taken to the patients after hematopoietic stem cell transplantation and solid organ transplantation. Voriconazole can cause phototoxicity, multiple erythema in sun-exposed areas may develop actinic keratosis and cutaneous squamous cell carcinoma (cSCC) while taking voriconazole. In North America and Europe, case reports of phototoxicity and aggressive cSCC in patients on voriconazole have been documented. Also 4 cases of voriconazole-associated cSCC have recently been reported in Japan. We describe a Japanese woman with multiple cSCC associated with recurrence of cSCC after discontinuing voriconazole. 


Multiple cutaneous squamous cell carcinoma; voriconazole; hematopoietic stem cell transplantation; reccurence; sun-exposed areas

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DOI: http://dx.doi.org/10.24294/ti.v2.i4.1079


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