At the board of directors of the Japanese Dermatological Association, Fukumi Furukawa, MD, PhD, Editor-in-chief of Trends in Immunotherapy (TI), was selected as the winner of the Master of Dermatology in 2022. The award ceremony and commemorative lecture will be held at the 121st Annual Meeting of the Japanese Dermatological Association in June. The reason for the award is “a series of studies on the elucidation of the pathogenic mechanism and establishment of treatment methods for cutaneous lesions of lupus erythematosus”. The “Master of Dermatology” is an award that pays homage to a Japanese dermatologist who has made significant contributions to the development of dermatology, such as clinical dermatology, dermatology research, human resource development, and social contribution. One person is honored every year. It was founded in 2010 and has been the current name since 2017.

References

Important articles on cutaneous lupus erythematosus are selected.

[Lupus model mice]

Maruyama N, Furukawa F, Nakai Y, Sasaki Y, Ohta K, Ozaki S, Hirose S, Shirai T. Genetic studies of autoimmunity in New Zealand mice. IV. Contribution of NZB and NZW genes to the spontaneous occurrence of retroviral gp70 immune complexes in (NZB X NZW)F1 hybrid and the correlation to renal disease. J Immunol 1983; 130: 740–746. PMID: 6217253

Furukawa F, Maruyama N, Yoshida H, Hamashima Y, Hirose S, Shirai T. Genetic studies on the skin lupus band test in New Zealand mice. Clin Exp Immunol 1985; 59: 146–152. PMID: 3871675

Furukawa F, Tanaka H, Sekita K, Nakamura T, Horiguchi Y, Hamashima Y. Dermatopathological studies on skin lesions of MRL mice. Arch Dermatol Res 1984; 276: 186–194. doi: 10.1007/BF00414018

Furukawa F, Ikehara S, Good RA, Nakamura T, Inoue S, Tanaka H, Imamura S, Hamashima Y. Immunological status of nude mice engrafted with allogeneic or syngeneic thymuses. Thymus 1988; 12: 11–26. PMID: 2977452

Yoshimasu T, Seo N, Hiroi A, Ohtani T, Uede K, Furukawa F. Susceptibility of T cell receptor-α chain knock-out mice to ultraviolet B light and fluorouracil: A novel model for drug-induced cutaneous lupus erythematosus. Clin Exp Immunol 2004; 136: 245–254. doi: 10.1111/j.1365-2249.2004.02458.x

Hiroi A, Ito T, Seo N, Uede K, Yoshimasu T, Ito M, Nakamura K, Ito N, Paus R, Furukawa F. Male New Zealand Black/KN mice: A novel model for autoimmune-induced permanent alopecia? Br J Dermatol 2006; 155: 437–445. doi: 10.1111/j.1365-2133.2006.07204.x

Inaba Y, Kanazawa N, Yoshimasu T, Shimokawa T, Nosaka M, Kondo T, Furukawa F. Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kit^wsh/wsh mutation. Mod Rheumatol 2018; 28: 319–326. doi: 10.1080/14397595.2017.1341591

[Human cutaneous lupus erythematosus]

Furukawa F, Lyons MB, Lee LA, Coulter SN, Norris DA. Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/Ro and SS-B/La. Another possible mechanism for estradiol influence of lupus erythematosus. J Immunol 1988; 141: 1480–1488. PMID: 2457617

Furukawa F, Kashihara-Sawami M, Lyons MB, Norris DA. Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): Implications for the pathogenesis of photosensitive cutaneous lupus. J Invest Dermatol 1990; 94: 77–85. doi: 10.1111/1523-1747.ep12873930

Furukawa F, Itoh T, Wakita H, Yagi H, Tokura Y, Norris DA, Takigawa M. Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity. Clin Exp Immunol 1999; 118: 164–170. PMID: 10540174

Furukawa F. Photosensitivity in cutaneous lupus erythematosus: lessons from mice to men. J Dermatol Sci 2003; 33: 81–89. doi: 10.1016/j.jdermsci.2003.08.005

Furukawa F, Yamamoto Y, Kanazawa N, Muto M. Race differences in immunogenetic features and photosensitivity of cutaneous lupus erythematosus from the aspect of Japanese studies. Ann N Y Acad Sci 2009; 1173: 552–556. doi: 10.1111/j.1749-6632.2009.04676.x

[Treatment and QOL]

Yoshimasu T, Ohtani T, Sakamoto T, Oshima A, Furukawa F. Topical FK506 (tacrolimus) therapy for facial erythematous lesions of cutaneous lupus erythematosus and dermatomyositis. Eur J Dermatol 2002; 12: 50–52. PMID: 11809595

Ishiguro M, Hashizume H, Ikeda T, Yamamoto Y, Furukawa F. Evaluation of the quality of life of lupus erythematosus patients with cutaneous lesions in Japan. Lupus 2014; 23: 93–101. doi: 10.1177/0961203313509293

Yokogawa N, Eto H, Tanikawa A, Ikeda T, Yamamoto K, Takahashi T, Mizukami H, Sato T, Yokota N, Furukawa F. Effects of hydroxychloroquine in patients with cutaneous lupus erythematosus: A multi-center double-blind randomized parallel-group trial. Arthritis Rheumatol 2017; 69: 791–799. doi: 10.1002/art.40018

Furukawa F. Hydroxychloroquine for the treatment of cutaneous lupus erythematosus. Trends Immunother 2021; 5(1): 7–13. doi: 10.24294/ti.v5.i1.1269

Furukawa F. Photosensitivity in lupus erythematosus. Aesthet Dermatol 2018; 28: 297–306. (abstract in English and text in Japanese)

[Autoinflammation and autoimmunity]

Arima K, Kinoshita A, Mishima H, Kanazawa N, Kaneko T, Mizushima T, Ichinose K, Nakamura H, Tsujino A, Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S, Ohmura K, Mimori T, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H, Yamakawa A, Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, Yoshiura K. Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci USA 2011; 108: 14914–14919. doi: 10.1073/pnas.1106015108

Furukawa F, Kanazawa N. Autoimmunity versus autoinflammation from the 2nd JSID-Asia-Oceania-Forum. J Dermatol Sci 2011; 63: 132–137. doi: 10.1016/j.jdermsci.2011.05.001

Kanazawa N, Furukawa F. Autoinflammatory syndromes with a dermatological perspective. J Dermatol Sci 2007; 34: 601–618. doi: 10.1111/j.1346-8138.2007.00342.x

Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK. Pluripotent stem cell model of Nakajo-Nishimura syndrome untangles proinflammatory pathways mediated by oxidative stress. Stem Cell Reports 2018; 10: 1835–1850. doi: 10.1016/j.stemcr.2018.04.004

[Global studies of International Conference on Cutaneous Lupus Erythematosus]

Furukawa F, Matsuura E. New impacts of cutaneous lupus erythematosus for global standard concepts. Autoimmun Rev 2009; 8: 439–440. doi: 10.1016/j.autrev.2008.12.009

Schultz HY, Dutz JP, Furukawa F, Goodfield MJ, Kuhn A, Lee LA, Nyberg F, Szepietowski JC, Sontheimer RD, Werth VP. From pathogenesis, epidemiology, and genetics to definitions, diagnosis, and treatments of cutaneous lupus erythematosus and dermatomyositis: a report from the 3rd International Conference on Cutaneous Lupus Erythematosus (ICCLE) 2013. J Invest Dermatol 2015; 135: 7–12. doi: 10.1038/jid.2014.316

Reich A, Werth VP, Furukawa F, Kuhn A, Szczęch J, Samotij D, Szepietowski JC. Treatment of cutaneous lupus erythematosus: current practice variations. Lupus 2016; 25: 964–972. doi: 10.1177/0961203316628997

Elman SA, Joyce C, Nyberg F, Furukawa F, Goodfield M, Hasegawa M, Marinovic B, Szepietowski J, Dutz J, Werth VP, Merola JF. Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise. J Am Acad Dermatol 2017; 77: 261–267. doi: 10.1016/j.jaad.2017.02.030

Samotij D, Szczęch J, Werth VP, Furukawa F, Kuhn A, Szepietowski JC, Reich A. Disease severity and prophylactic measures in patients with cutaneous lupus erythematosus: results of a worldwide questionnaire-based study. Postepy Dermatol Alergol 2018; 35: 192–198. doi: 10.5114/ada.2018.75242

Samotij D, Szczęch J, Kushner CJ, Mowla MR, Dańczak-Pazdrowska A, Antiga E, Chasset F, Furukawa F, Hasegawa M, Hashizume H, Islam A, Ikeda T, Lesiak A, Polańska A, Misery L, Szepietowski JC, Tsuruta D, Adamski Z, Werth VP, Reich A. Prevalence of pruritus in cutaneous lupus erythematosus: Brief report of a multicenter, multinational cross-sectional study. Biomed Res Int 2018; 3491798. doi: 10.1155/2018/3491798.

Samotij D, Szczech J, Antiga E, Bonciani D, Caproni M, Chasset F, Dańczak-Pazdrowska A, Furukawa F, Hasegawa M, Hashizume H, Ikeda T, Islam A, Kim HJ, Lesiak A, Misery L, Mowla MR, Polańska A, Szepietowski J, Tsuruta D, Verdelli A, Werth V, Reich A. Clinical characteristics of itch in cutaneous lupus erythematosus: A prospective, multicenter, multinational, cross-sectional study. Lupus 2021; 30: 1385–1393. doi: 10.1177/09612033211016098