Ethnomedicinal properties of Bael Aegle marmelos Corrêa family Rutaceae: A review
Vol 6, Issue 2, 2023
VIEWS - 501 (Abstract) 295 (PDF)
Abstract
Bael or Aegle marmelos Corrêa is considered a sacred tree by Hindus and is offered to Lord Shiva while worshipping. It grows in the Indian subcontinent and Southeast Asia and is called by various names in different regions. Bael has been used as a traditional medicine in India and other Southeast Asian countries to treat various ailments, including diarrhea, chronic dysentery, constipation, gonorrhea, catarrh, diabetes, deafness, inflammations, ulcerated intestinal mucosa, intermittent fever, melancholia, heart palpitation, and also to control fertility. The ethnomedicinal properties of Bael are owing to its ability to synthesize alkaloids, cardiac glycosides, anthocyanins, flavonoids, steroids, saponins, terpenoids, tannins, lignins, quinones, coumarins, proteins, carbohydrates, amino acids, reducing sugars, fats, and oils. The aegeline, auroptene, umbelliferone, psoralene, marmin, imperatorin, xylorhamnoarabinogalactan I pectic polysaccharide and skimmianine are synthesized by different parts of Bael, and they have shown antibacterial, anti-inflammatory, analgesic, anti-allergic, anthelmintic, antidiabetic, anticancer, cardioprotective and neuroprotective activities in various experimental models. The present review has been written consulting various publications, and different websites including Google Scholar, Pubmed, ScienceDirect, and Google.
Keywords
Full Text:
PDFReferences
1. Crepet WL. Progress in understanding angiosperm history, success, and relationships: Darwin’s abominably “perplexing phenomenon”. Proceedings of the National Academy of Sciences 2000; 97(24): 12939–12941. doi: 10.1073/pnas.97.24.12939
2. Stevenson DW, Zimmermann MH, Stevens P, et al. Angiosperm. Available online: https://www.britannica.com/plant/angiosperm (accessed on 2 November 2023).
3. Groppo M, Afonso LF, Pirani JR. A review of systematics studies in the Citrus family (Rutaceae, Sapindales), with emphasis on American groups. Brazilian Journal of Botany 2022; 45(1): 181–200. doi: 10.1007/s40415-021-00784-y
4. Singh A, Sharma HK, Kaushal P, Upadhyay A. Bael (Aegle marmelos Correa) products processing: A review. African Journal of Food Science 2014; 8(5): 204–215. doi: 10.5897/AJFS2013.1119
5. Bel-Rhlid R, Berger RG, Blank I. Bio-mediated generation of food flavors—Towards sustainable flavor production inspired by nature. Trends in Food Science & Technology 2018; 78: 134–143. doi: 10.1016/j.tifs.2018.06.004
6. Sonawane A, Pathak S, Pradhan RC. Bioactive compounds in bael fruit pulp waste: Ultrasound-assisted extraction, characterization, modeling, and optimization approaches. Biointerface Research in Applied Chemistry 2021; 11(2): 9318–9334. doi: 10.33263/BRIAC112.93189334
7. Sharma PC, Bhatia V, Bansal N, Sharma A. A review on Bael tree. Natural Product Radiance 2007; 6(2): 171–178.
8. Singh AK, Singh S, Saroj PL, et al. Research status of bael (Aegle marmelos) in India: A review. Indian Journal of Agricultural Sciences 2019; 89(10): 1563–1571. doi: 10.56093/ijas.v89i10.94576
9. Akbar S. Agele marmelos (L.) Corrêa (Rutaceae). In: Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications, 1st ed. Springer; 2020. pp. 109–122. doi: 10.1007/978-3-030-16807-0
10. Roy SK, Singh RN. Bael fruit (Aegle marmelos)—A potential fruit for processing. Economic Botany 1979; 33: 203–212. doi: 10.1007/BF02858290
11. Mali SS, Dhumal RL, Havaldar VD, et al. A systematic review on Aegle marmelos (Bael). Research Journal of Pharmacognosy and Phytochemistry 2020; 12(1): 31–36. doi: 10.5958/0975-4385.2020.00007.2
12. Sharma N, Dubey W. History and taxonomy of Aegle marmelos: A review. International Journal of Pure and Applied Bioscience 2013; 1(6): 7–13.
13. Pathirana CK, Madhujith T, Eeswara J. Bael (Aegle marmelos L. Corrêa), a medicinal tree with immense economic potentials. Advances in Agriculture 2020; 2020: 8814018. doi: 10.1155/2020/8814018
14. Kumar KPS, Umadevi M, Bhowmik D, et al. Recent trends in medicinal uses and health benefits of Indian traditional herbs Aegle marmelos. The Pharma Innovation 2012; 1(4): 57–65.
15. Swathi G. Aegle marmelos (Bael): A Hand Book on Sacred Bilwa Plant with Medicinal Properties. International E—Publication; 2014.
16. Hazra K, Dutta S, Kumar Mandal A, et al. Comprehensive dossier on Ayurvedic medicinal plant Aegle marmelos (L.) Corrêa.: A review. The Pharmaceutical & Chemical Journal 2017; 4(3): 55–74.
17. Bhar K, Mondal S, Suresh P. An eye-catching review of Aegle marmelos L. (Golden Apple). Pharmacognosy Journal 2019; 11(2): 207–224. doi: 10.5530/pj.2019.11.34
18. Choudhary S, Chaudhary G, Kaurav H. Aegle marmelos (bael patra): An ayurvedic plant with ethnomedicinal value. International Journal of Research in Ayurveda and Pharmacy 2021; 12(3): 147–156. doi: 10.7897/2277-4343.120392
19. Balkrishna A. Flora of Morni Hills (Research & Possibilities). Divya Yoga Mandir Trust; 2018. 581p.
20. Dhankhar S, Ruhil S, Balhara M, et al. Aegle marmelos (Linn.) Correa: A potential source of Phytomedicine. Journal of Medicinal Plants Research 2011; 5(9): 1497–1507.
21. Vasava D, Kher MM, Nataraj M, Teixeira da Silva JA. Bael tree (Aegle marmelos (L.) Corrêa): Importance, biology, propagation, and future perspectives. Trees 2018; 32: 1165–1198. doi: 10.1007/S00468-018-1754-4
22. Chopra RN, Nayar SL, Chopra IC, et al. Glossary of Indian Medicinal Plants. National Institute of Science Communication and Information Resources; 2002.
23. Jagetia GC, Venkatesh P, Baliga MS. Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biological and Pharmaceutical Bulletin 2005; 28(1): 58–64. doi: 10.1248/bpb.28.58
24. Basu D, Sen R. Alkaloids and coumarins from root-bark of Aegle marmelos. Phytochemistry 1974; 13(10): 2329–2330. doi: 10.1016/0031-9422(74)85057-0
25. Kirtikar K, Basu B. Indian Medicinal Plants, 2nd ed. Oriental Enterprises; 2001. Volume 4.
26. Charoensiddhi S, Anprung P. Bioactive compounds and volatile compounds of Thai bael fruit (Aegle marmelos (L.) Correa ) as a valuable source for functional food ingredients. International Food Research Journal 2008; 15(3): 287–295.
27. Rajan S, Gokila M, Jency P, et al. Antioxidant and phytochemical properties of Aegle marmelos fruit pulp. International Journal of Current Pharmaceutical Research 2011; 3(2): 65–70.
28. Rafiqkhan M, Radhakrishnan D, Mohamed M, et al. Phytochemical screening of Aegle marmelos (L.) correa fruit pulp: A potential source of ethnomedicine. World Journal of Pharmaceutical Research 2013; 2(6): 2919–2927.
29. Laddha CS, Kunjalwar SG, Itankar PR, Tauqeer M. Nutritional and phytochemical assesment of wild edible fruit of Aegle marmelos (Linn.) used by the tribes of Bhiwapur Tahsil Nagpur district, India. Asian Journal of Pharmaceutical Clinical Research 2015; 8(1): 76–78.
30. Kejariwal M. Evaluation of antioxidant potential and phytochemical investigations on Aegle marmelos (L.) Corr. Bulletin of Environment, Pharmacology and Life Sciences 2016; 5(2): 42–52.
31. Kaur A, Kalia M. Physico chemical analysis of Bael (Aegle Marmelos) fruit pulp, seed and pericarp. Chemical Science Review and Letters 2017; 6(22): 1213–1218.
32. Gupta A, Thomas T, Khan S. Physicochemical, phytochemical screening and antimicrobial activity of Aegle marmelos. Pharmaceutical and Biosciences Journal 2018; 6(3): 17–24. doi: 10.20510/ukjpb/6/i3/173548
33. Chaubey A, Dubey A. Phytochemical profiling and antioxidant activity of aqueous extract of Aegle marmelos fruit shell. In: Proceedings of the MOL2NET'18, Conference on Molecular, Biomedical, Computational Sciences and Engineering; 15 January 2018–20 January 2019; Cambridge, UK & Duluth, USA. doi: 10.3390/MOL2NET-04-05432
34. Sivakumar G, Gopalasatheeskumar K, Gowtham K, et al. Phytochemical analysis, antioxidant and antiarthritic activities of different solvent extract of Aegle marmelos l. Unripe fruit. Research Journal of Pharmacy and Technology 2020; 13(6): 2759–2763. doi: 10.5958/0974-360X.2020.00490.4
35. Thaware P, Karale P, Karale M, Chavan P. Phytochemical screening and pharmacological evaluation of Aegle marmelos fruit. Indian Drugs 2020; 57(4): 59–64.
36. Sarkar A, Rashid M, Musarrat M, Billah M. Phytochemicals and nutritional constituent evaluation of Bael (Aegle marmelos) fruit pulp at different development stage. Asian Food Science Journal 2021; 20(1): 78–86. doi: 10.9734/afsj/2021/v20i130257
37. Ganpat SP, Jagdish SD, Onkarappa GR. Quantitative phytochemical analysis and in vitro study of antioxidant and anti-inflammatory activities of Aegle marmelos fruit with peel and without peel: A comparative evaluation. International Journal of Pharmaceutical Investigation 2022; 12(1): 15–19. doi: 10.5530/ijpi.2022.1.3
38. Kudlur DS, Meghashree AM, Vinutha SA, et al. One pot synthesis of CuO-NiO nanoparticles using Aegle marmelos fruit extract and their antimicrobial activity. Materialstoday: Proceedings 2023; 89: 1–7. doi: 10.1016/j.matpr.2023.03.256
39. Siddique NA, Mujeeb M, Najmi AK, Akram M. Evaluation of antioxidant activity, quantitative estimation of phenols and flavonoids in different parts of Aegle marmelos. African Journal of Plant Science 2010; 4(1): 1–5.
40. Hameed MA, Faheem A, Koay YC, Fathima S. Phytochemical screening, anti-pyretic and antidiarrhoeal activities of the n-hexane and aqueous extracts of the leaves of Aegle marmelos. Archives of Pharmacy Practice 2011; 2(3): 90–94.
41. Ariharan VN, Prasad PN. Quantitative phytochemical analysis on leaf extract of Aegle marmelos. Journal of Chemical and Pharmaceutical Research 2014; 6(3): 1100–1104.
42. Mujeeb F, Bajpai P, Pathak N. Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos. BioMed Research International 2014; 2014: 497606. doi: 10.1155/2014/497606
43. Asaduzzaman M, Nahar L, FazleyRabbi M, et al. Phytochemicals, nutritonal constituents, anti-bacterial and hypoglycemic activity of Aegle marmelos Lin. leaf extract in alloxan induced diabetic rats. Journal of Nutrition & Food Sciences 2016; 6(4): 1000533. doi: 10.4172/2155-9600.1000533
44. Shantaram BP, Ramachandra BS, Eknath GA. Preliminary phytochemical analysis of seeds and leaves of Aegle marmelos extracts and in-vitro assessment of their antibacterial activity. International Journal of Pharma Research and Health Sciences 2016; 4(4): 1315–1319. doi: 10.21276/ijprhs.2016.04.13
45. Raja WW, Khan SH. Estimation of some phytoconstituents and evaluation of antioxidant activity in Aegle marmelos leaves extract. Journal of Pharmacognosy and Phytochemistry 2017; 6(1): 37–40.
46. Asghar N, Mushtaq Z, Arshad MU, et al. Phytochemical composition, antilipidemic and antihypercholestrolemic perspectives of Bael leaf extracts. Lipids in Health and Disease 2018; 17(1): 68. doi: 10.1186/S12944-018-0713-9
47. Gade R, Deshmukh AA, Patil MK, et al. Comparative study of phytochemical analysis and extractive value of Aegle marmelos, Bauhinia racemosa and Psidium guajava. Journal of Pharmacognosy and Phytochemistry 2018; 7(5): 2904–2907.
48. Veer B, Singh R. Phytochemical screening and antioxidant activities of Aegle marmelos leaves. Analytical Chemistry Letters 2019; 9(4): 478–485. doi: 10.1080/22297928.2019.1657946
49. Sahu AK, Kar BR, Deepthi K, et al. Gas chromatography and mass spectroscopy analysis and phytochemical characterization of Aegle marmelos (Bael) leaf, stem and its screening of antimicrobial activity. GSC Biological and Pharmaceutical Sciences 2019; 8(3): 122–130. doi: 10.30574/gscbps.2019.8.3.0159
50. Seemaisamy R, Faruck LH, Gattu S, et al. Anti-microbial and anti-cancer activity of Aegle marmelos and gas chromatography coupled spectrometry analysis of their chemical constituents. International Journal of Pharmaceutical Sciences and Research 2019; 10(1): 373–380. doi: 10.13040/IJPSR.0975-8232.10(1).373-80
51. Syahrir M, Kadola E, Salempa P. Isolation and identification of secondary metabolites in ethyl acetate extract from the Maja bark (Aegle marmelos Linn.). Pharmaciana 2021; 11(1): 15–24. doi: 10.12928/pharmaciana.v11i1.17875
52. Anandhu KS, Jose M, Kuriakose S, Jayalakshmi PM. Phytochemical analysis and in vitro antidiabetic activity of aqueous extract of Lagerstroemia speciosa and Aegle marmelos. Research Journal of Pharmacy and Technology 2021; 14(9): 4697–4701. doi: 10.52711/0974-360X.2021.00816
53. Ahmad W, Amir M, Ahmad A, et al. Aegle marmelos leaf extract phytochemical analysis, cytotoxicity, in vitro antioxidant and antidiabetic activities. Plants 2021; 10(12): 2573. doi: 10.3390/plants10122573
54. Tripathi M, Shukla PK, SIkarwar RLS, et al. Pharmacognostic evaluation of Bilva [Aegle marmelos (L.) Correa] root bark. Indian Journal of Traditional Knowledge 2019; 18(4): 670–676.
55. Sharma GN, Dubey SK, Sati N, Sanadya J. Phytochemical screening and estimation of total phenolic content in Aegle marmelos seeds. International Journal of Pharmaceutical and Clinical Research 2011; 2(3): 27–29.
56. Dheeba B, Sampathkumar P, Sathiya Priya RR, Kannan M. Phytochemical studies and evaluation of antioxidant potential of various extracts of Aegle marmelos bark. Pharmacologyonline 2010; 3: 831–839.
57. Meena AK, Ilavarasan R, Singh R, Parashar D, et al. Evolution of pharmacological activity with molecular docking of active constituents present in roots and small branches of Aegle marmelos: A comparative study using HPLC, GC-MS, LC-MS. Phytomedicine Plus 2022; 2(1): 100210. doi: 10.1016/j.phyplu.2021.100210
58. Sharma A, Singh T, Pathak D, et al. Antidepressive-like effect of Aegle marmelos leaf extract in chronic unpredictable mild stress-induced depression-like behaviour in rats. BioMed Research International 2022; 2022: 6479953. doi: 10.1155/2022/6479953
59. Kumar DR, Awasthi K. Phytochemical analysis of Aegle marmelos leaves: A comparative study. European Chemical Bulletin 2023; 12(S8): 3576–3582.
60. Rathore M. Nutrient content of important fruit trees from arid zone of Rajasthan. Journal of Horticulture and Forestry 2009; 1(7): 103–108.
61. Lakht-e-Zehra A, Dar NG, Saleem N, et al. Nutritional exploration of leaves, seed and fruit of bael (Aegle marmelos L.) grown in Karachi region. Pakistan Journal of Biochemistry and Molecular Biology 2015; 48(3): 61–65.
62. Sharma K, Chauhan ES. Nutritional and phytochemical evaluation of fruit pulp powder of Aegle marmelos (Bael). Journal of Chemical and Pharmaceutical Sciences 2017; 10(2): 809–814.
63. Uttarwar VV, Taur AT, Sawate AR. Studies on evaluation of physicochemical and nutritional properties of bael fruit (Aegle marmelos). Journal of Pharmacognosy and Phytochemistry 2018; 7(3): 547–549.
64. Manandhar MD, Shoeb A, Kapil RS, Popli SP. New alkaloids from Aegle marmelos. Phytochemistry 1978; 17(10): 1814–1815. doi: 10.1016/S0031-9422(00)88714-2
65. Ali MS, Pervez MK. Marmenol: A 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr. Natural Product Research 2004; 18(2): 141–146. doi: 10.1080/14786410310001608037
66. Phuwapraisirisan P, Puksasook T, Jong-aramruang J, Kokpol U. Phenylethyl cinnamides: A new series of α-glucosidase inhibitors from the leaves of Aegle marmelos. Bioorganic & Medicinal Chemistry Letters 2008; 18(18): 4956–4958. doi: 10.1016/j.bmcl.2008.08.024
67. Garg SN, Siddiqui MS, Agarwal SK. p-Menth-1-en-3β,5β-diol, a new constituent of Aegle marmelos leaf oil. Journal of Essential Oil Research 1995; 7(3): 283–286. doi: 10.1080/10412905.1995.9698520
68. Kaur HP, Garg SN, Sashidhara KV, et al. Chemical composition of the essential oil of the twigs and leaves of Aegle marmelos. Journal of Essential Oil Research 2006; 18(3): 288–289. doi: 10.1080/10412905.2006.9699091
69. Mahomoodally MF, Mollica A, Stefanucci A, et al. Volatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A functional approach. Industrial Crops and Products 2018; 126: 13–21. doi: 10.1016/j.indcrop.2018.09.054
70. Gajbhiye NA, Makasana J, Dhanani T, Saravanan R. Development and validation of LC—ESI—MS/MS method for simultaneous determination of four coumarin derivatives and an alkaloid from root and stem bark of Aegle marmelos Correa. Acta Chromatographica 2016; 28(4): 473–488. doi: 10.1556/1326.2016.28.4.6
71. Laphookhieo S, Phungpanya C, Tantapakul C, et al. Chemical constituents from Aegle marmelos. Journal of the Brazilian Chemical Society 2011; 22(1): 176–178. doi: 10.1590/S0103-50532011000100024
72. Gajbhiye NA, Makasana J, Thorat T. Simultaneous determination of marmin, skimmianine, umbelliferone, psoralene, and imperatorin in the root bark of Aegle marmelos by high-performance thin-layer chromatography. Journal of Planar Chromatography 2012; 25: 306–313. doi: 10.1556/JPC.25.2012.4.5
73. Chatterjee A, Saha SK. Isolation of alloimperatorin and ß-sitosterol from the fruits of Aegle rnarrnelos. Journal of the Indian Chemical Society 1957; 34: 228–230.
74. Sharma BR, Sharma P. Constituents of Aegle marmelos. II. Alkaloids and coumarin from fruits. Planta Medica 1981; 43(1): 102–103.
75. Chaubey A, Dubey AK. Chemistry and antioxidant potential of phytoconstituents from Aegle Marmelos fruit-shell. Current Drug Metabolism 2020; 21(7): 525–533. doi: 10.2174/1389200221666200711161056
76. Hye JK, Young JS, Khin MH, Kee DY. Chemical constituents from Aegle marmelos fruits. Natural Product Sciences 2021; 27(4): 240–249. doi: 10.20307/nps.2021.27.4.240
77. Mandal PK, Mukherjee AK. Studies on bael (Aegle marmelos) seed glycoproteins. Carbohydrate Research 1981; 90(2): 233–241. doi: 10.1016/S0008-6215(00)85922-4
78. Mishra BB, Singh DD, Kishore N, et al. Antifungal constituents isolated from the seeds of Aegle marmelos. Phytochemistry 2010; 71(2–3): 230–234. doi: 10.1016/j.phytochem.2009.10.013
79. Chinchansure AA, Shamnani N, Arkile M, et al. Antimycobacterium activity of coumarins from fruit pulp of Aegle marmelos (L.) Correa. International Journal of Basic and Applied Chemical Sciences 2015; 5(3): 39–44.
80. Pynam H, Dharmesh SM. Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers. Biomedicine & Pharmacotherapy 2018; 106: 98–108. doi: 10.1016/j.biopha.2018.06.053
81. Nugroho AE, Riyanto S, Sukari MA, Maeyama K. Anti-allergic effects of marmin, a coumarine isolated from Aegle marmelos Correa: In vitro study. International Journal of Phytomedicine 2011; 3(1): 84–97.
82. Nugroho AE, Abdi N, Riyanto S, et al. Effects of marmin isolated from Aegle marmelos Correa on L-histidine decarboxylase enzyme in RBL-2 H3 cells. The Thai Journal of Pharmaceutical Sciences 2011; 35(1): 1–7.
83. Narender T, Shweta S, Tiwari P, et al. Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. Bioorganic & Medicinal Chemistry Letters 2007; 17(6): 1808–1811. doi: 10.1016/j.bmcl.2006.12.037
84. Ram PP, Varun G, Balram S, et al. Extraction and isolation of marmelosin from Aegle Marmelos, synthesis and evaluation of their derivative as antidiabetic agent. Der Pharmacia Lettre 2012; 4(4): 1085–1092.
85. Singh AP, Singh L, Singh P, Bhatti R. Biological evaluation of Aegle marmelos fruit extract and isolated aegeline in alleviating pain−depression dyad: In silico analysis of aegeline on MAO‑A and iNOS. ACS Omega 2021; 6(3): 2034–2044. doi: 10.1021/acsomega.0c04739
86. Noviarsito P, Riyanto S, Nugroho AE. Marmin of Aegle Marmelos Correa antagonizes AChM3 receptors: In silico and in vitro studies on isolated guinea pig illeum smooth muscle. Journal of Mathematical and Fundamental Sciences 2014; 46(3): 278–289. doi: 10.5614/j.math.fund.sci.2014.46.3.6
87. Murugaiah K, Venkatachalam R. Antispasmolytic and anti helminthiasis activity of aegeline isolated from Aegle marmelos leaves. Journal of Global Biosciences 2015; 4(1): 1235–1238.
88. Sahare KN. Antifilarial screening and oxidative role of isolated fraction from Aegle marmelos Corr. leaves extract. Biosciences Biotechnology Research Asia 2021; 18(2): 395–401. doi: 10.13005/bbra/2926
89. Kakiuchi N, Senaratne LRE, Huang SL, et al. Effects of constituents of Beli (Aegle marmelos) on spontaneous beating and calcium-paradox of myocardial cells. Planta Medica 1991; 57(1): 43–46. doi: 10.1055/S-2006-960014
90. Napolitano HB, Silva M, Ellena J, et al. Aurapten, a coumarin with growth inhibition against Leishmania major promastigotes. Brazilian Journal of Medical and Biological Research 2004; 37(12): 1847–1852. doi: 10.1590/S0100-879X2004001200010
91. Katram N, Garlapati PK, Yadavalli C, et al. Aegle marmelos extract rich in marmelosin exacted ameliorative effect against chromium-induced oxidative stress and apoptosis through regulation of Gadd45 in HepG2 cell line. Journal of Food Biochemistry 2021; 45(4): e13704. doi: 10.1111/jfbc.13704
92. Manda VK, Avula B, Chittiboyina AG, et al. Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents. Xenobiotica 2016; 46(2): 117–125. doi: 10.3109/00498254.2015.1053006
93. Pynam H, Dharmesh SM. A xylorhamnoarabinogalactan I from Bael (Aegle marmelos L.) modulates UV/DMBA induced skin cancer via galectin-3 & gut microbiota. Journal of Functional Foods 2019; 60: 103425. doi: 10.1016/j.jff.2019.103425
94. Mohammed MMD, Ibrahim NA, El-Sakhawy FS, et al. Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa. Natural Product Research 2016; 30(22): 2559–2566. doi: 10.1080/14786419.2015.1126262
95. Nugroho AE, Riyanto S, Sukari MA, Maeyama K. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pakistan Journal of Pharmaceutical Sciences 2011; 24(3): 359–367.
DOI: https://doi.org/10.24294/th.v6i2.2941
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This site is licensed under a Creative Commons Attribution 4.0 International License.