Antioxidants are derivatives of vitamin C or beta-carotene that prevent reactions stimulated by oxygen, peroxides, or free radicals, thus reducing the oxidative stress. They have found their way into many uses in treating several human diseases and reducing the risk of developing diseases like cancer. In view of this property, the present study was focussed in identifying several plants possessing antioxidative properties and which were also conserved in the ex-situ park of CSIR – Central Institute of Mining and Fuel Research, Dhanbad, India. Fifteen medicinal plants including herbs, shrubs and grasses are reported in this paper, and a collective insight has been presented about their antioxidant properties and the present state of their pharmacological applications. The specific chemical constituents abundant in the leaves, roots, stems, seeds and fruits of each of these plants have also been dealt with. To report a few antioxidant pharmacological preparations from Ayurvedic literature are Vimang, Maharishi Amrit Kalash (MAK4, MAK5), Maharishi Ayurved (MA631, MA47), MA Raja’s Cup, MA Student Rasayana and MA Ladies Rasayana. This review has been attempted to enhance the importance of the plants which are generally being neglected, so that it can used by the local people in rural areas for their cultivation and it will also pave the pathway for their subsequent future use in medicinal and research industry for drug formulation.

1. Croft KD. Antioxidant effects of plant phenolic compounds. In T. K. Basu, N. J. Temple, & M. L. Garg (Eds.), Antioxidants in human health and disease. New York: CABI Publishing, 1999.109–112.

2. Lemberkovics E, Czinner E, Szentmiha lyi K, et al. Comparative evaluation of Helichrysiflos herbal extracts as dietary sources of plant polyphenols, and macro- and microelements. Food Chemistry 2002; 78(1): 119–127.

3. Sami A. Oxidative stress and antioxidant defences in biology. New York: Chapman & Hall, 1995.

4. Shon MY, Kim TH, Sung NJ. Antioxidants and free radical scavenging activity of Phellinusbaumii (Phellinus of Hymenochaetaceae) extracts. Food Chemistry 2003; 82(4): 593–597.

5. Wilson RL. Free radicals and tissue damage, mechanistic evidence from radiation studies. In: Biochemical Mechanisms of Liver Injury. Academic Press: New York 1998. 123.

6. Velioglu YS, Mazza G, Gao L et al. Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. Journal of Agricultural and Food Chemistry1998; 46(9):4113–4117.

7. Nunes PX, Silva SF, Guedes RJ et al. Biological oxidations and antioxidant activity of natural products, Phytochemicals as nutraceuticals - Global Approaches to Their Role in Nutrition and Health 2012.

8. Chanda S, Dave R. In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: an overview. Afr J Microbiol Res. 2009; 3: 981-996.

9. Sumner J. The natural history of medicinal plants(1st ed.) . Portland, Oregon, USA: Timber Press 2000.

10. Larson RA. The antioxidants of higher plants. Phytochemistry 1988;4: 969-/978.

11. Hertog MGL, Hollman PCH, Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Nederlands. J. Agric. Food Chem.1992; 40: 2379-2383.

12. Cao G, Sofic E, Prior RL. Antioxidant capacity of tea and common vegetables, J. Agric. Food Chem. 1996; 44: 3426-3431.

13. Kivits GAA, Vam der Sman FJP, Tijburg LBM. Analysis of catechin from green and black tea in humans: a specific and sensitive colorimetric assay of total catechins in biological fluids, Int. J. Food Sci. Nutr. 1997; 48:387-392.

14. Nagarajan, S, Jain HC, Aulakh GS. Indigenous Plants Used in the Control of Diabetes. Publication and Information Directorate CSIR New Delhi: 1987. 586.

15. Jain SR, Sharma SN. Hypoglycemic drugs of Indian indigenous origin. Planta Medica 1967; 15: 439-442.

16. Anjali P, Manoj KM. Same comments on diabetes and herbal therapy. Ancient Sci. Life1995; 15: 27-29.

17. Gutteridge JMC. Antioxidants, nutritional supplements and life-threatening diseases. British Journal of Biomedical Science1994; 51: 288–295.

18. Saija A, Scalese M, Lanza M, et al. Flavonoids as antioxidant agents: importance of their interaction with biomembrane. Free Radicals Biology and Medicine 1995;19 (4):481–486.

19. Van den Berg DJ. Structural aspects of antioxidant activity of flavonoids. Free Radicals Biology and Medicine 1996; 20 (3): 331–342.

20. Govind P. Medicinal plants against liver diseases. IJPR 2011; 2:115–121.

21. Shikhar K, Devendra P, Shailja G,et al. Some Indian Traditional Medicinal Plants with Antioxidant Activity: A Review. International Journal of Innovative Research in Science, Engineering and Technology 2013; 2(12).

22. Nigam V, Sodhi JS. Some medicinal plants with antioxidant activity- a review International Journal of pharmacy and biological sciences 2014; 4(1): 173-178.

23. Kusuma IW, Arung ET, Kim Y-u. Antimicrobial and Antioxidant Properties of Medicinal Plants Used by the Bentian Tribe from Indonesia. Food Science and Human Wellness 2014; 3(4):191-196.

24. Scartezzini P, Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. Journal of Ethnopharmacology 2000; 71:23–43.

25. Ferreira C, Proenc MLM, Serralheiro MEM, et al. The in vitro screening for acetyl cholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal of Ethnopharmacology 2006; 108:31–37.

26. Chang WC, Sei CK, Soon SH, et al. Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison. Plant Science 2002; 163: 1161-1168.

27. Saeed LN, Muhammad RK, Maria S. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla. BMC Complementary and Alternative Medicine 2012; 12:221.

28. Pourmorad F, Hosseinimehr SJ, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants Afr. J. Biotechnol. 2006; 5:1142-1145.

29. Singh RS, Ansari I, Singh RK, Singh SK, et al.Medicinal plants in ex-situ conservation and its therapeutic in mine impacted lands of dry tropical forests of Jharkhand, India. Eurasian Journal of Forest Science 2017; 5(2): 44-69.

30. Ansari I, Sharma SN, Sundararajan M, et al. Medicinal plant in Jharkhand state: an overview of current scenario. Global Journal of Engineering Science and Researches 2016; 6(2):1-6.

31. Jain SK, Rao RR. Handbook of Field and Herbarium Methods. New Delhi: Goyal Offsets, 1977.

32. Sanchez GM, Re L, Giuliani A, et al Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacological Research2000; 42: 565-573.

33. Muruganandan S, Gupta S, Kataria M, et al. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Toxicology 2002;176:165-173.

34. Leiro JM, Alvarez E, Arranz JA, et al. In vitro effects of mangiferin on superoxide concentrations and expression of the inductible nitric oxide synthase, tumor necrosis factor-α and transforming growth factor-β genes. Biochemical Pharmacology 2003; 65: 1361-137.

35. Stoilova I, Gargova S, Stoyanova A, et al .Antimicrobial and antioxidant activity of the polyphenol mangiferin. Herbal Polonica 2005; 51:37-44.

36. Wauthoz N, Balde A, Balde ES, et al. Ethnopharmacology of Mangifera indica L. Bark and Pharmacological Studies of its Main C-Glucosylxanthone, Mangiferin. International Journal of Biomedical and Pharmaceutical Sciences 2007; 1(2): 112-119.

37. Chukwuemeka PA, Cynthia AU, Nwamaka HI, et al. In vitro antisickling, antimicrobial and antioxidant potentials of extracts of Sorghum bicolor (L) Moench seeds and Mangifera indica (L) Anacardiaceae leaves and their formulations. Journal of Science and Practice of Pharmacy 2016; 3 (1): 135-144.

38. Bushra S, Zaib H, Muhammad A, et al.Investigation on the Antioxidant Activity of Leaves, Peels, Stems Bark, and Kernel of Mango (Mangifera indica L.) Journal of Food Science 2012; 77(8).

39. Lai TL, Su AY, Ammu KR, et al.Standardised Mangifera indica extract is an ideal antioxidant. Food Chemistry 2009; 113:1154–1159.

40. Ribeiro SMR, Barbosa LCA, Queiroz JH, et al .Phenolic compounds and antioxidant capacity of Brazilian mango (Mangifera indica L.) varieties. Food Chemistry 2008; 110:620–626.

41. Molly A, Darsan BM, Joel J, et al. Phytochemical analysis and antioxidant activity of Alstonia scholaris Pharmacognosy Journal 2011;3(26):13-18.

42. Jagetia GC, Baliga MS. The effect of seasonal variation on the antineoplastic activity of Alstonia scholaris R. Br. in HeLa cells. Journal of Ethnopharmacology 2005; 96: 37–42.

43. Arulmozhi S, Mazumder PM, Ashok P, et al. In Vitro Antioxidant and free radical scavenging activity of Alstonia scholaris Linn. R. Br. Iran.J. Pharmacol. Ther. 2007; 6:191–196.

44. Ravi SK, Ramesh, KVRNS, Naveena P. Free radical scavenging activity of the flower and fruit extracts of Alstonia scholaris. Biosci. Biotechnol. Res. Asia 2008; 5:493–494.

45. Kumar A, Kaur R, Arora S. Free radical scavenging potential of some Indian medicinal plants. J. Med. Plants Res 2010; 4: 2034–2042.

46. Arulmozhi S, Mazumder PM, Narayanan LS, et al. In vitro antioxidant and free radical scavenging activity of fractions from Alstonia scholaris Linn. R. Br. Int. Journal of Pharm Tech Res 2010; 2: 18–25.

47. James J, Thaliyil V, Kumar AK, et al. In vitro antioxidant activity of flowers and fruits of Alstonia scholaris. Int. J. Phytomed. 2011;3: 475–479.

48. Zhang XF, Tan Benny KH. Antihyperglycaemic and anti-oxidant properties of andrographis paniculata in normal and diabetic rats. Clinical and Experimental Pharmacology and Physiology 2000; 27:358–363.

49. Verma N, Vinayak M. Antioxidant action of Andrographis paniculata on lymphoma. Mol Biol Rep 2008; 35:535–540.

50. Trivedi NP, Rawal UM. Hepatoprotective and antioxidant property of Andrographis paniculata Nees in BHC induced liver damage in mice. Indian J Exp Biol 2001;39: 41-6.

51. Sheeja K, Shihab PK, Kuttan G. Antioxidant and anti-inflammatory activities of the plant Andrographis paniculata Nees. Immunopharmacol Immunotoxicol 2006; 28:129-40.

52. Rodeiro I, Cancino L, Gonzalez JE, et al. Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. Food and Chemical Toxicology 2006; 44: 1707–1713.

53. Singh RP, Banerjee S, Rao RA. Modulatory Influence of Andrographis paniculata on Mouse Hepatic and Extrahepatic Carcinogen Metabolizing Enzymes and Antioxidant Status Phytother. Res. 2001; 15: 382–390.