The Nobel Prize in Physiology or Medicine 2023 was awarded for discoveries concerning base modifications that enabled the development of effective mRNA vaccines against COVID-19

Fukumi Furukawa

Article ID: 3463
Vol 8, Issue 1, 2024

VIEWS - 564 (Abstract) 179 (PDF)

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References


1. Available online: https://www.nobelprize.org/prizes/medicine/2023/press-release/ (accessed on 18 October 2023).

2. Available online: https://www.nobelprize.org/prizes/medicine/2023/summary/ (accessed on 18 October 2023).

3. Karikó K, Buckstein M, Ni H, et al. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA. Immunity. 2005, 23(2): 165-175. doi: 10.1016/j.immuni.2005.06.008

4. Karikó K, Muramatsu H, Welsh FA, et al. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability. Molecular Therapy. 2008, 16(11): 1833-1840. doi: 10.1038/mt.2008.200

5. Anderson BR, Muramatsu H, Nallagatla SR, et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Research. 2010, 38(17): 5884-5892. doi: 10.1093/nar/gkq347

6. Kayano T, Sasanami M, Kobayashi T, et al. Number of averted COVID-19 cases and deaths attributable to reduced risk in vaccinated individuals in Japan. The Lancet Regional Health - Western Pacific. 2022, 28: 100571. doi: 10.1016/j.lanwpc.2022.100571

7. Lamprinou M, Sachinidis A, Stamoula E, et al. COVID-19 vaccines adverse events: potential molecular mechanisms. Immunologic Research. 2023, 71(3): 356-372. doi: 10.1007/s12026-023-09357-5

8. Ogata AF, Cheng CA, Desjardins M, et al. Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clinical Infectious Diseases. 2021, 74(4): 715-718. doi: 10.1093/cid/ciab465

9. Ghaderi S, Mohammadi S. Post-COVID-19 vaccination and the brain: A critical analysis of CNS MRI findings. Trends in Immunotherapy. 2023, 7(2): 2885. doi: 10.24294/ti.v7.i2.2885

10. Ishikawa O. The pathophysiology and clinical phenotypes of COVID-19 mRNA vaccine-related cutaneous adverse reactions: A narrative review. Trends in Immunotherapy [in press].

11. Matsuo A, Nakashima C, Yanagihara S, et al. Two cases of COVID-19 vaccine-related erythema multiforme under the administration of immune checkpoint inhibitors. Trends in Immunotherapy. 2023, 7(2): 2683. doi: 10.24294/ti.v7.i2.2683

12. Furukawa F. The Nobel Prize in Physiology or Medicine 2018 was awarded to Cancer Therapy by Inhibition of Negative Immune Regulation. Trends in Immunotherapy. 2018, 2(1). doi: 10.24294/ti.v2.i1.1065




DOI: https://doi.org/10.24294/ti.v8.i1.3463

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