A case of unilateral epidermal nevi complicated by atopic dermatitis treated with dupilumab

Yumi Nagatsuka, Chisa Nakashima, Naomi Kitayama, Yoshio Ishida, Kenji Kabashima, Atsushi Otsuka

Article ID: 2773
Vol 8, Issue 1, 2024

VIEWS - 453 (Abstract) 111 (PDF)

Abstract


Epidermal Nevus Syndrome (ENS) is a congenital disorder characterized by skin lesions called epidermal nevi. This condition typically appears at birth or in infancy. However, a case of adult‐onset epidermal nevi was reported in a 36‐year‐old male with a history of atopic dermatitis (AD) and skin abnormalities on the right side of his body. He had been using topical steroids for AD but eventually started dupilumab treatment at age 41. The treatment led to significant improvements in his skin condition, including a reduction in erythema and scaling. Laboratory tests also showed improvement in serum Immunoglobulin E (IgE) levels and other markers. We report with a literature review.


Keywords


atopic dermatitis; epidermal nevi; dupilumab; unilateral

Full Text:

PDF


References


1. Kitayama N, Otsuka A, Kaku Y, et al. Case of unilateral epidermal nevi without extracutaneous anomalies. The Journal of Dermatology 2016; 43(10): 1241–1242. doi: 10.1111/1346-8138.13380

2. Mizutani Y, Nagai M, Iwata H, et al. Epidermal nevus syndrome associated with dwarfism and atopic dermatitis. Children 2021; 8(8): 267. doi: 10.3390/children8080697

3. Yuan T, Lu X, Tang B, et al. Differences in clinical characteristics and lesion proteomics between inflammatory linear verrucous epidermal nevus and local verrucous epidermal nevus. Journal of Proteomics 2022; 260: 104554. doi: 10.1016/j.jprot.2022.104554

4. Nguyen JK, Austin E, Huang A, et al. The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets. Archives of Dermatological Research 2020; 312: 81–92. doi: 10.1007/s00403-019-01972-3




DOI: https://doi.org/10.24294/ti.v8.i1.2773

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Yumi Nagatsuka, Chisa Nakashima, Naomi Kitayama, Yoshio Ishida, Kenji Kabashima, Atsushi Otsuka

License URL: https://creativecommons.org/licenses/by-nc/4.0/

This site is licensed under a Creative Commons Attribution 4.0 International License.