Harnessing the crosstalk of adipocytes, autophagy, and immune cells for immunotherapy in obesity

Gloria G. Guerrero M

Article ID: 1654
Vol 6, Issue 2, 2022, Article identifier:29-39

VIEWS - 176 (Abstract) 32 (PDF)


As a self-degradative and recycling program, autophagy plays an essential role in homeostasis and life. The connection between autophagy and the status of the adipose tissue (white or beige/brown) links to metabolic diseases such as obesity, type two diabetes mellitus (T2DM). Moreover, autophagy and the renin-angiotensin physiological system play a pivotal role in metabolic syndrome, a disease that can disrupt homeostasis in different organs, including adipose tissue. The crosstalk in adipose tissue maintains low inflammation, brown adipocytes, and autophagic machinery under control. The JAK-STAT signalization pathway and the paracrine action of hormones, adipokines, and cytokines play a role in maintaining the status of low inflammation, brown adipocytes, and autophagic machinery to harness the utmost for obesity immunotherapy.


Autophagy; Adipocytes; Immune System; Leptin; Obesity; Type Two Diabetes Mellitus (T2DM)

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DOI: http://dx.doi.org/10.24294/ti.v6.i2.1654


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