Peristomal pyoderma gangrenosum successfully treated with cyclosporine

Shoko Urano, Jinnroh Abe, Hirotoshi Kikuchi

Article ID: 1474
Vol 6, Issue 2, 2022, Article identifier:4-8

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Peristomal pyoderma gangrenosum (PPG) is an uncommon subtype of pyoderma gangrenosum. We describe a 74-year-old woman without inflammatory bowel disease (IBD) who developed PG around the jejunostomy and was successfully treated with cyclosporine. In our case, irritations by a lumbar corset and repeated sutures around the jejunostomy seemed to have caused pathergy reaction. It is noteworthy that 20% of PPG patients do not have IBD and therefore patients presenting PPG without IBD should not be overlooked.


Peristomal Pyoderma Gangrenosum; Jejunostomy; Pathergy; Cyclosporine

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McGarity WC, Robertson DB, McKeown PP, et al. Pyoderma gangrenosum at the parastomal site in patients with Crohn’s disease. Archives of Surgery 1984; 119(10): 1186–1188. doi: 10.1001/archsurg.1984.01390220064014

Barbosa NS, Tolkachjov SN, el-Azhary RA, et al. Clinical features, causes, treatments, and outcomes of peristomal pyoderma gangrenosum (PPG) in 44 patients: The Mayo Clinic experience, 1996 through 2013. Journal of the American Academy of Dermatology 2016; 75: 931–939. doi: 10.1016/j.jaad.2016.05.044

Afifi L, Sanchez IM, Wallace MM, et al. Diagnosis and management of peristomal pyoderma gangrenosum: A systematic review. Journal of the American Academy of Dermatology 2018; 78: 1195–1204. doi: 10.1016/j.jaad.2017.12.049

Davis C, Wright B. Healing of a pyoderma gangrenosum at the site of a percutaneous endoscopically sited gastrostomy tube without tube removal. Case Reports 2014; 2014: bcr2014204301. doi: 10.1136/bcr-2014-204301

Lockenhofer F, Wollina U, Salva KA, et al. The PARAELSUS score: A novel diagnostic tool for pyoderma gangrenosum. British Journal of Dermatology 2019; 180: 615–620. doi: 10.1111/bjd.16401

Hashizume H, Kageyama R, Umayahara T, et al. A case of pyoderma arthritis, pyoderma gangrenosumu, and acne (PAPA) syndrome successfully treated with combination therapy of corticosteroids, cyclosporine, and colchicine. Trends in Immunotherapy 2018. doi: 10.24294/ti.v2.i2.719

Okuno A, Kanda Y, Nakano H, et al. Therapeutic effects of cyclosporine on Hailey-Hailey disease. Trends in Immunotherapy 2019; 3(1): 58–61. doi: 10.24294/ti.v3.i1.1140



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