Durable complete response to combination nivolumab and ipilimumab in metastatic renal cell carcinoma

Kenta Takayasu, Koei Muguruma, Hidefumi Kinoshita

Article ID: 1387
Vol 6, Issue 1, 2022

VIEWS - 912 (Abstract)

Abstract


Immune checkpoint inhibitors, which promote or suppress the anti-tumor immune response, are becoming the mainstay of cancer treatment. In 2018, CheckMate 214 study showed a higher response rate with ipilimumab and nivolumab combination therapy compared to conventional therapy for advanced renal cell carcinoma. We report a case of complete response and durable response for two years to ipilimumab and nivolumab combination therapy in a patient with postoperative renal cancer recurrence that caused immune-related adverse events such as interstitial pneumonia and hepatotoxicity.


Keywords


Immune Checkpoint Inhibitor; Ipilimumab; Nivolumab; Combination Therapy; Advanced Renal Cell Carcinoma; Durable Response; Immune-related Adverse Events

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DOI: https://doi.org/10.24294/ti.v6.i1.1387

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