Pathomechanism of malignant melanoma

Motonobu Nakamura

Article ID: 1280
Vol 5, Issue 1, 2021

VIEWS - 1364 (Abstract) 398 (PDF)

Abstract


Treatment of malignant melanoma has made great strides in the last decade. On the one hand, immune checkpoint inhibitors and molecular targeted drugs improved the prognosis of patients. On the other hand, it is very important to be aware of the causes of malignant melanoma based on the latest knowledge. In this review, I will briefly review the carcinogenic mechanism of malignant melanoma from the aspects of ultraviolet rays, mechanical stress, trauma and so on.


Keywords


Malignant Melanoma; Mutation; Ultraviolet Ray; Pathomechanism

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References


1. Furukawa F. The Nobel Prize in Physiology or Medicine 2018 was awarded to cancer therapy by inhibition of negative immune regulation. Trends in Immunotherapy 2018; 2. doi: 10.24294/ti.v2.i3.10 65

2. Seidel JA, Otsuka A, Kabashima K. Treating tumors with immune checkpoint inhibitors: Rationale and limitations. Trends in Immunotherapy 2017; 1(1): 2–9. doi: 10.24294/ti.v1.i1.20

3. Furukawa F. Effects of immune checkpoint inhibitors on cancer patients with preexisting autoimmune disease. Trends in Immunotherapy 2021; 5(1): 5–6. doi: 10.24294/ti.v5.i1.1250

4. Yano S, Okuno A, Furukawa F. Severe type of erythema multiforme (EM major) due to administration of Anti-PD-1 antibody drug. Trends in Immunotherapy 2021; 5(1): 1–4. doi: 10.24294/ti.v5.i1.12 47

5. Adachi E, Yokoyama E, Yamagami Y, et al. Bullous pemphigoid induced by nivolumab in a patient with malignant melanoma. Trends in Immunotherapy 2020; 4(1): 15–17. doi: 10.24294/ti.v4.i1.1210

6. Inaba H, Ariyasu H, Okuhira H, et al. Endocrine dysfunctions during treatment of immune-checkpoint inhibitors. Trends in Immunotherapy 2020; 4(1): 18–26. doi: 10.24294/ti.v4.i1.606

7. Yamazaki F. Solar UV rays and skin cancer (in Japanese). The Japanese Journal of Dermatology 2014; 124(6): 1121–1126. doi: https://doi.org/10.14 924/dermatol.124.1121

8. Setlow RB, Woodhead AD, Grist E. Animal model for ultraviolet radiation-induced melanoma: Platy-fish-swordtail hybrid. Proceedings of the National Academy of Sciences of the United States of America 1989; 86(22): 8922–8926. doi: 10.1073/pn as.86.22.8922

9. Noonan FP, Recio JA, Takayama H, et al. Neonatal sunburn and melanoma in mice. Nature 2001; 413(6853): 271–272. doi: 10.1038/35095108

10. Kunisada T, Lu S, Yoshida H, et al. Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor. Journal of Experimental Medicine 1998; 187(10): 1565–1573. doi: 10.1084/jem.187.1 0.1565

11. Yamazaki F, Okamoto H, Matsumura Y, et al. Development of a new mouse model (xeroderma pigmentosum adeficient, stem cell factor-transgenic) of ultraviolet B-induced melanoma. Journal of Investigative Dermatology 2005; 125(3): 521–525. doi: 10.1111/j.0022-202X.2005.23753.x

12. Minagawa A, Omodaka T, Okuyama R. Melanomas and mechanical stress points on the plantar surface of the foot. The New England Journal of Medicine 374: 2404–2406. doi: 10.1056/NEJMc1512354

13. Takai I, Katsuura J, Kubota Y. A case of malignant melanoma of the nail — Summary of reported cases caused by trauma (in Japanese). Japanese Journal of Clinical Dermatology 2006; 60(3): 282–284. doi: https://doi.org/10.11477/mf.1412100550

14. Omoto M, Hayama K, Kimura K, et al. Pediatric cases of acral lentiginous melanoma under the nail plate (in Japanese). Rinsho derma (Tokyo) 2019; 61(9): 1444–1448. doi: https://doi.org/10.18888/hi. 0000001555

15. Otsu M, Nagase K, Inoue T, et al. Multiple squamous cell cancers and intraepidermal malignancies caused by chronic radiation dermatitis (in Japanese). Practical Dermatology 2015; 37(10): 1001–1004. doi: https://doi.org/10.24733/J01268.2016019656

16. Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102(5): 553–563. doi: 10.1016/s0092-8674(00)00078-7

17. Okura R, Yoshioka H, Yoshioka M, et al. Expression of AID in malignant melanoma with BRAFV600E mutation. Experimental Dermatology 2014; 23(5): 347–348. doi: 10.1111/exd.12402

18. Nonaka T, Toda Y, Hiai H, et al. Involvement of activation induced cytidine deaminase in skin cancer development. The Journal of Clinical Investigation 2016; 126(4): 1367–1382. doi: 10.1172/JCI815 22




DOI: https://doi.org/10.24294/ti.v5.i1.1280

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