CAR-T Therapy for Solid Tumors: Development of New Strategies

Marvin de los Santos; Samuel D. Bernal

doi:10.24294/ti.v4.i2.1064

CAR-T Therapy for Solid Tumors: Development of New Strategies

Marvin de los Santos, Samuel D. Bernal

Article ID: 1064
Vol 4, Issue 2, 2020, Article identifier:87-104

VIEWS - 488 (Abstract) 239 (PDF)

Abstract

The recent approval of two CAR-T therapies by US Food and Drug Administration (FDA) marks a very significant development in cell-based cancer immunotherapy. This milestone was demonstrated by the effectiveness of eradicating hematologic cancers using CD19-specific CARs. The success spurred development of immune cell therapies for other cancers, especially solid tumors. The generation of novel CAR constructs for these cancer types represents a major challenge in bringing the technology ‘from-bench-to-bedside‘.In this review, we outline some new technologies we have developed to equip CAR-T cells to enhance efficiency while decreasing toxicity of CAR-T therapies in solid tumors.

Keywords

Cancer Immunotherapy; Chimeric Antigen Receptor T cell Therapy; Lymphoma; Solid Tumors; Cancer Molecular Profiling

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DOI: http://dx.doi.org/10.24294/ti.v4.i2.1064