Objective: This study assessed the prevalence of psychological disorders and their correlation with health-promoting lifestyles among Chinese college students. Method: We used the Chinese version of the Depression Anxiety Stress Scales-21 (DASS-21) and the Health Promoting Lifestyle Profile II (HPLP-II) questionnaires. Gender and major differences were analyzed with the chi-square test, and multiple logistic regression explored the relationship between HPLP and psychological disorders. Results: Among 17,636 students, low prevalence rates were observed for stress (4.0%), depression (7.2%), and anxiety (15.4%). Females and students in humanities and social sciences reported higher rates of multiple psychological disorders. Higher HPLP scores were inversely correlated with depression (OR = 0.479, 95% CI: 0.376–0.609), anxiety (OR = 0.480, 95% CI: 0.408–0.565), and stress (OR = 0.821, 95% CI: 0.636–1.060) after adjusting for confounders. Conclusions: The study found low overall prevalence of psychological disorders, with higher rates among females and humanities/social sciences majors. Higher HPLP scores, particularly in interpersonal relationships and nutrition, are associated with a lower risk of mental disorders.

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