In the highly competitive employment environment, most college students have left their jobs for a short time after employment, and attention should be paid to students’ career adaptation. However, the further influence of skilled goal orientation, social support and career-determined self-efficacy on college students’ career adaptation needs to be confirmed. This study analyzes the effects of these factors on college students’ career adaptation. This study aims to analyze the impact of mastery goal orientation, social support, and vocational decision self-efficacy on career adaptation among 224 university students in East China. The results indicated that university students generally exhibit positive levels of mastery goal orientation, social support, vocational decision self-efficacy, and overall career adaptation. Female students demonstrate higher levels of mastery goal orientation, social support, vocational decision self-efficacy, and career adaptation compared to male students. As students progress in their academic years, their levels of mastery goal orientation, social support, vocational decision self-efficacy, and career adaptation tend to increase. Students majoring in humanities and social sciences have higher level than students majoring in science and engineering in all factors. Students majoring in humanities and social sciences exhibit more optimism in all factors compared to students in science and technology fields. The relationships among these factors show positive correlations. Mastery goal orientation, social support, and vocational decision self-efficacy all have positive effects on career adaptation. Among these, family support stands out as the most influential subordinate factor of social support on career adaptation. The most influential subordinate factor of vocational decision self-efficacy on career adaptation is conscious decision-making. Therefore, male, lower grade, science and engineering college students are the groups that need to be paid attention to in improving career adaptation. Skilled goal orientation, family support and conscious decision making have a better effect on the improvement of career adaptation. These results can provide important reference information for universities, counselors and college students in the training of career planning, and theoretically enrich the relevant research on college students’ career adaptation, and provide certain enlightenment for future researchers.

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