Metal iodide materials as novel components of thermal biological and medical systems at the interface between heat transfer techniques and therapeutic systems. Due to their outstanding heat transfer coefficients, biocompatibility, and thermally activated sensitivity, metal iodides like silver iodide (AgI), copper iodide (CuI), and cesium iodide (CsI) are considered to be useful in improving the performance of medical instruments, thermal treatment processes, and diagnostics. They are examined for their prospective applications in controlling thermal activity, local heating therapy, and smart temperature-sensitive drug carrier systems. In particular, their application in hyperthermia therapy for cancer treatment, infrared thermal imaging for diagnosis, and nano-based drug carriers points to a place for them in precision medicine. But issues of stability of materials used, biocompatibility, and control of heat—an essential factor that would give the tools the maximum clinical value—remain a challenge. The present mini-review outlines the emerging area of metal iodides and their applications in medical technologies, with a special focus on the pivotal role of these materials in enhancing non-invasive, efficient, and personalized medicine. Over time, metal iodide-based systems scouted a new era of thermal therapies and diagnostic instrumentation along with biomedical science as a whole.

1. Sklyar AM, Kalinkevich OV, Holubnycha VN, et al. Easily obtained iodine and silver-iodine doped chitosan for medical and other applications. Carbohydrate Polymer Technologies and Applications. 2023; 5: 100318. doi: 10.1016/j.carpta.2023.100318

2. Xie W, Chen J, Zhang Y, et al. Copper iodine cluster nanoparticles for tumor-targeted X-ray-induced photodynamic therapy. Science China Materials. 2024; 67(10): 3358-3367. doi: 10.1007/s40843-024-2958-1

3. Li H, Zhang Y, Zhang J, et al. Bimetallic-based colorimetric sensor for highly selective, stable and sensitive detection of iodide ions. Microchemical Journal. 2024; 199: 110098. doi: 10.1016/j.microc.2024.110098

4. Zhang R, Xie H, Wang F, et al. Near‐Infrared and Cyan Dual‐Band Emission Copper Iodide Based Halides with [Cu6I9] 3−Cluster. Laser & Photonics Reviews; 2024.

5. Dissanayake PD, Yeom KM, Sarkar B, et al. Environmental impact of metal halide perovskite solar cells and potential mitigation strategies: A critical review. Environmental Research. 2023; 219: 115066. doi: 10.1016/j.envres.2022.115066

6. Cruz-Jiménez AE, Argumedo-Castrejón PA, Mateus-Ruiz JB, et al. Deoxygenation of heterocyclic N-oxides employing iodide and formic acid as a sustainable reductant. New Journal of Chemistry. 2024; 48(21): 9424-9428. doi: 10.1039/d4nj00913d

7. Lei Y, Yin M, Shi C, et al. Tailored molecular for ultra-stability and biocompatible pseudohalide metal-free perovskite towards X-ray detectors with record sensitivity. npj Flexible Electronics. 2024; 8(1). doi: 10.1038/s41528-024-00330-2

8. Chen J, Zhou K, Li J, et al. Strongly photoluminescent and radioluminescent copper(i) iodide hybrid materials made of coordinated ionic chains. Chemical Science. 2025; 16(3): 1106-1114. doi: 10.1039/d4sc06242f

9. Singh G, Shankar G, Panda SR, et al. Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer’s Disease. ACS Chemical Neuroscience. 2024; 15(7): 1388-1414. doi: 10.1021/acschemneuro.3c00679

10. Tang W, Xing G, Xu X, et al. Emerging Hybrid Metal Halide Glasses for Sensing and Displays. Sensors. 2024; 24(16): 5258. doi: 10.3390/s24165258

11. Liu D, Dang P, Zhang G, et al. Near‐infrared emitting metal halide materials: Luminescence design and applications. InfoMat. 2024; 6(5). doi: 10.1002/inf2.12542

12. Shyamal S, Pradhan N. Nanostructured Metal Chalcohalide Photocatalysts: Crystal Structures, Synthesis, and Applications. ACS Energy Letters. 2023; 8(9): 3902-3926. doi: 10.1021/acsenergylett.3c01236

13. Hu M, Zhu Y, Zhou Z, et al. Post‐Treatment of Metal Halide Perovskites: From Morphology Control, Defect Passivation to Band Alignment and Construction of Heterostructures. Advanced Energy Materials. 2023; 13(41). doi: 10.1002/aenm.202301888

14. Zhou Y, Zhang H, Xian Y, et al. Enhancing charge-emitting shallow traps in metal halide perovskites by >100 times by surface strain. Joule. 2025; 9(1): 101772. doi: 10.1016/j.joule.2024.10.004

15. Abánades Lázaro I, Chen X, Ding M, et al. Metal–organic frameworks for biological applications. Nature Reviews Methods Primers. 2024; 4(1). doi: 10.1038/s43586-024-00320-8

16. Chen L, Liu T, Wang X, et al. Near‐Theoretical Thermal Conductivity Silver Nanoflakes as Reinforcements in Gap‐Filling Adhesives. Advanced Materials. 2023; 35(31). doi: 10.1002/adma.202211100

17. Liu J, Feng H, Dai J, et al. A Full-component recyclable Epoxy/BN thermal interface material with anisotropy high thermal conductivity and interface adaptability. Chemical Engineering Journal. 2023; 469: 143963. doi: 10.1016/j.cej.2023.143963

18. Kumar A, Kumar A. Heat transfer analysis in thermal energy storage—A comprehensive review‐based latent heat storage system. Energy Storage. 2022; 5(6). doi: 10.1002/est2.434

19. Zhao H, Ye Z, Li J, et al. Enhancing Thermal Conductivity of Thermal Interface Materials through Aligned Liquid Metal Pillars: A Promising Strategy. ACS Applied Polymer Materials. 2024; 6(8): 4431-4440. doi: 10.1021/acsapm.3c02917

20. Wang H, Xu F, Ding W, et al. Amphiphilic ionic liquids as catalysts for efficient synthesis of novel isosorbide-based optical polymers with good biocompatibility and tunable properties. Chemical Engineering Journal. 2024; 485: 149715. doi: 10.1016/j.cej.2024.149715

21. Meera K, Ramesan M. A review on the influence of various metal oxide nanoparticles on structural, morphological, optical, thermal and electrical properties of PVA/PVP blends. Journal of Thermoplastic Composite Materials. 2023; 37(9): 3036-3057. doi: 10.1177/08927057231222833

22. Arab K, Jafari A, Shahi F. The role of graphene quantum dots in cutting‐edge medical therapies. Polymers for Advanced Technologies. 2024; 35(9). doi: 10.1002/pat.6571

23. Almeida MB, Galdiano CMR, Silva Benvenuto FSR da, et al. Strategies Employed to Design Biocompatible Metal Nanoparticles for Medical Science and Biotechnology Applications. ACS Applied Materials & Interfaces. 2024; 16(49): 67054-67072. doi: 10.1021/acsami.4c00838

24. Pan T, Yang K, Dong X, et al. Adsorption-based capture of iodine and organic iodides: status and challenges. Journal of Materials Chemistry A. 2023; 11(11): 5460-5475. doi: 10.1039/d2ta09448g

25. Ebe H, Suzuki R, Sumikoshi S, et al. Guanidium iodide treatment of size-controlled CsPbI3 quantum dots for stable crystal phase and highly efficient red LEDs. Chemical Engineering Journal. 2023; 471: 144578. doi: 10.1016/j.cej.2023.144578

26. Chen Q, Chen S, Ma J, et al. Synergic anchoring of Fe2N nanoclusters on porous carbon to enhance reversible conversion of iodine for high-temperature zinc-iodine battery. Nano Energy. 2023; 117: 108897. doi: 10.1016/j.nanoen.2023.108897

27. Chee TS, Lee S, Ng WJ, et al. Bi0–Reduced Graphene Oxide Composites for the Enhanced Capture and Cold Immobilization of Off-Gas Radioactive Iodine. ACS Applied Materials & Interfaces. 2023; 15(34): 40438-40450. doi: 10.1021/acsami.3c06761

28. Yaqoob T, Ahmad M, Faiz Y, et al. Retention of methyl iodide on metal and TEDA impregnated activated carbon using indigenously developed setup. Environmental Research. 2023; 238: 117133. doi: 10.1016/j.envres.2023.117133

29. Gao Z, Zhou Y, Zhang J, et al. Advanced Energy Harvesters and Energy Storage for Powering Wearable and Implantable Medical Devices. Advanced Materials. 2024. doi: 10.1002/adma.202404492

30. Alemaryeen A, Noghanian S. A Survey of the Thermal Analysis of Implanted Antennas for Wireless Biomedical Devices. Micromachines. 2023; 14(10): 1894. doi: 10.3390/mi14101894

31. Dentis A. Wireless Charging and Power Management System for Biomedical Implantable Devices. Politecnico di Torino; 2023.

32. Zannou AL. Use of Bioheat Modeling to Characterize and Optimize Implantable Medical Devices and Neuromodulation Technologies. The City College of New York; 2023.

33. Zhang L, Hu X, Chen Y, et al. Multiple in-situ reactions induced by biodegradable iodides: A synergistically chemodynamic-photothermal therapy platform. Chemical Engineering Journal. 2023; 465: 142699. doi: 10.1016/j.cej.2023.142699

34. Feng Y, Chen Q, Jin C, et al. Microwave-activated Cu-doped zirconium metal-organic framework for a highly effective combination of microwave dynamic and thermal therapy. Journal of Controlled Release. 2023; 361: 102-114. doi: 10.1016/j.jconrel.2023.07.046

35. Zhao X, Li T, Guo T, et al. Supramolecular Structure of the β-Cyclodextrin Metal–Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications. ACS Applied Materials & Interfaces. 2024; 16(19): 24235-24247. doi: 10.1021/acsami.4c02258

36. Scafa Udriște A, Burdușel A, Niculescu AG, et al. Metal-Based Nanoparticles for Cardiovascular Diseases. International Journal of Molecular Sciences. 2024; 25(2): 1001. doi: 10.3390/ijms25021001

37. Yu M, Li S, Ren X, et al. Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer. ACS Nano. 2024; 18(4): 3636-3650. doi: 10.1021/acsnano.3c11433

38. Ismail YH, Wang K, Al Shehhi M, et al. Iodide ion-imprinted chitosan beads for highly selective adsorption for nuclear wastewater treatment applications. Heliyon. 2024; 10(3): e24735. doi: 10.1016/j.heliyon.2024.e24735

39. Ghosh SK, Mbileni Morema CN, Mallick K. Electrical performance of organic molecule stabilized ultrafine tin(II) iodide particles: Towards an in-situ sensing application. Chemical Physics Letters. 2024; 854: 141556. doi: 10.1016/j.cplett.2024.141556

40. Chu D, Jia B, Liu N, et al. Lattice engineering for stabilized black FAPbI 3 perovskite single crystals for high-resolution x-ray imaging at the lowest dose. Science Advances. 2023; 9(35). doi: 10.1126/sciadv.adh2255

41. Guo C, Chen C, Wan R, et al. Iodide-based glass with combination of high transparency and conductivity: A novel promising candidate for transparent microwave absorption and radar stealth. Chemical Engineering Journal. 2024; 484: 148930. doi: 10.1016/j.cej.2024.148930

42. Chen P, Wang J, Xue Y, et al. From challenge to opportunity: Revolutionizing the monitoring of emerging contaminants in water with advanced sensors. Water Research. 2024; 265: 122297. doi: 10.1016/j.watres.2024.122297

43. Khan SA, Khan NZ, Sohail M, et al. Recent developments of lead-free halide-perovskite nanocrystals: Synthesis strategies, stability, challenges, and potential in optoelectronic applications. Materials Today Physics. 2023; 34: 101079. doi: 10.1016/j.mtphys.2023.101079

44. Harrington B, Ye Z, Signor L, et al. Luminescence Thermometry Beyond the Biological Realm. ACS Nanoscience Au. 2023; 4(1): 30-61. doi: 10.1021/acsnanoscienceau.3c00051

45. Badidi E. Edge AI for Early Detection of Chronic Diseases and the Spread of Infectious Diseases: Opportunities, Challenges, and Future Directions. Future Internet. 2023; 15(11): 370. doi: 10.3390/fi15110370

46. Aabed K, Mohammed AE. Synergistic and Antagonistic Effects of Biogenic Silver Nanoparticles in Combination With Antibiotics Against Some Pathogenic Microbes. Frontiers in Bioengineering and Biotechnology. 2021; 9. doi: 10.3389/fbioe.2021.652362

47. de Solorzano IO, Alejo T, Abad M, et al. Cleavable and thermo-responsive hybrid nanoparticles for on-demand drug delivery. Journal of Colloid and Interface Science. 2019; 533: 171-181. doi: 10.1016/j.jcis.2018.08.069

48. Wei W, Lu P. Designing Dual-Responsive Drug Delivery Systems: The Role of Phase Change Materials and Metal–Organic Frameworks. Materials. 2024; 17(13): 3070. doi: 10.3390/ma17133070

49. Xia Y, Liu C, Zhao X, et al. Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy. Materials Today Bio. 2024; 29: 101345. doi: 10.1016/j.mtbio.2024.101345

50. Chen C, Zhang W, Wang P, et al. Thermo-responsive composite nanoparticles based on hydroxybutyl chitosan oligosaccharide: Fabrication, stimulus release and cancer therapy. International Journal of Biological Macromolecules. 2024; 276: 133842. doi: 10.1016/j.ijbiomac.2024.133842

51. Mansha M, Abbas N, Altaf F, et al. Nanomaterial-based probes for iodide sensing: synthesis strategies, applications, challenges, and solutions. Journal of Materials Chemistry C. 2024; 12(14): 4919-4947. doi: 10.1039/d3tc04611g

52. Tawiah B, Ofori EA, Chen D, et al. Sciento-qualitative study of zinc-iodine energy storage systems. Journal of Energy Storage. 2024; 79: 110086. doi: 10.1016/j.est.2023.110086

53. Song L, Fan Y, Fan H, et al. Photo-assisted rechargeable metal batteries. Nano Energy. 2024; 125: 109538. doi: 10.1016/j.nanoen.2024.109538