Innovative extraction technologies

Dušica P. Ilić, Danica Vukotić

Article ID: 3000
Vol 6, Issue 2, 2023

VIEWS - 2121 (Abstract) 1458 (PDF)

Abstract


The enormous biological potential of herbal products is one of the main reasons for their frequent use in the production of dietary supplements and functional foods, which, in addition to their nutritional properties, have pharmacological and physiological effects. New scientific knowledge on the isolation of pharmacologically active compounds from complex matrices has led to significant advances in this field. Today, the process of extraction plays a significant scientific role, with “green” technologies occupying a special place in today’s science. Herbal medicine is one of the oldest human skills, which has worn off with its centuries-old application in the path of modern medicine. Microwave-assisted extraction, or more simply, microwave extraction, is a new extraction technique that combines traditional extraction solvents and microwaves. The mentioned method takes less time, consumes less energy, and has strong penetration power into the plant matrix to obtain more oils, but it can also reduce production costs. This can eventually increase the quality of the final product and reduce the product price at the consumer level. Microwave-assisted extraction could be useful to the herbal industry for oil extraction as well as other pharmaceutically important plant components. Based on a comparison and study of published literature, this research examines the present state of extraction procedures. This review includes a detailed discussion of the most important extraction techniques.


Keywords


extraction techniques; conventional extraction; supercritical extraction; ultrasonic-assisted extraction; microwave-assisted extraction

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References


1. Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine 2018; 13: 20. doi: 10.1186/s13020-018-0177-x

2. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. Journal of Natural Products 2012; 75(3): 311–335. doi: 10.1021/np200906s

3. Cragg MG, Newman JD. Natural products: A continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA)—General Subjects 2013; 1830(6): 3670–3695. doi: 10.1016/j.bbagen.2013.02.008

4. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances 2015; 33(8): 1582–1614. doi: 10.1016/j.biotechadv.2015.08.001

5. Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products 2016; 79(3): 629–661. doi: 10.1021/acs.jnatprod.5b01055

6. Rice EL. Biological Control of Weeds and Plant Diseases: Advances in Applied Allelopathy. University of Oklahoma Press; 1995. pp. 383–426.

7. Christaki E, Bonos E, Giannenas I, Florou-Paneri P. Aromatic plants as a source of bioactive compounds. Agriculture 2012; 2(3): 228–243. doi: 10.3390/agriculture2030228

8. Christaki E, Giannenas I, Bonos E, et al. Chapter 2—Innovative uses of aromatic plants as natural supplements in nutrition. In: Florou-Paneri P, Christaki E, Giannenas I (editors). Feed Additives: Aromatic Plants and Herbs in Animal Nutrition and Health. Academic Press; 2020. pp. 19–34.

9. Hatt S, Xu Q, Francis F, Osawa N. Aromatic plants of East Asia to enhance natural enemies towards biological control of insect pests. A review. Entomologia Generalis 2019; 38(4): 275–315. doi: 10.1127/entomologia/2019/0625

10. Ilić DP, Nikolić VD, Nikolić LB, et al. Thermal degradation, antioxidant and antimicrobial activity of the synthesized allicin and allicin incorporated in gel. Hemijska Industrija 2010; 64(2): 85–91. doi: 10.2298/HEMIND091111003I

11. Chaves JO, de Souza MC, da Silva LC, et al. Extraction of flavonoids from natural sources using modern techniques. Frontiers in Chemistry 2020; 8: 507887. doi: 10.3389/fchem.2020.507887

12. Švarc-Gajić J. Sample preparations fundamentals for chromatography. In: Solid Phase Extraction. Nova Science Pub Inc.; 2010. pp. 94–133.

13. Stanojević L, Stanković M, Cakić M, et al. The effect of hydrodistillation techniques on yield, kinetics, composition and antimicrobial activity of essential oils from flowers of Lavandula officinalis L. Hemijska Industrija 2011; 65(4): 455–463. doi: 10.2298/HEMIND110129047S

14. Stanojević LP, Stanojević JS, Cvetković DJ, et al. Antioxidant activity of the ethanolic extract of the leaf of the wild strawberry (Fragariae folium). Hemijska Industrija 2015; 69(5): 567–576. doi: 10.2298/HEMIND140718077S

15. Stanojević LP, Radulović NS, Đokić TM, et al. The yield, composition and hydrodistillation kinetics of the essential oil of dill seeds (Anethi fructus) obtained by different hydrodistillation techniques. Industrial Crops and Products 2015; 65: 429–436. doi: 10.1016/j.indcrop.2014.10.067

16. Stanojević LP, Stanković MZ, Cvetković DJ, et al. The effect of extraction techniques on yield, extraction kinetics, and antioxidant activity of aqueous-methanolic extracts from nettle (Urtica dioica L.) leaves. Separation Science and Technology 2016; 51(11): 1817–1829. doi: 10.1080/01496395.2016.1178774

17. Ilić DP, Stanojević LP, Troter DZ, et al. Improvement of the yield and antimicrobial activity of fennel (Foeniculum vulgare Mill.) essential oil by fruit milling. Industrial Crops and Products 2019; 142: 111854. doi: 10.1016/j.indcrop.2019.111854

18. Ilić DP, Stanojević JS, Cvetković DJ, et al. Grinding of Serbian peppermint (Mentha × piperita L.) leaves: Variations regarding yield, composition and antimicrobial activity of isolated essential oil. Advanced Technologies 2022; 11(1): 5–12. doi: 10.5937/savteh2201005I

19. Damjanović B, Lepojević Ž, Živković V, Tolić A. Extraction of fennel (Foeniculum vulgare Mill.) seeds with supercritical CO2: Comparison with hydrodistillation. Food Chemistry 2005; 92(1): 143–149. doi: 10.1016/j.foodchem.2004.07.019

20. Cravotto G, Boffa L, Mantegna S, et al. Improved extraction of vegetable oils under high-intensity ultrasound and/or microwaves. Ultrasonics Sonochemistry 2008; 15(5): 898–902. doi: 10.1016/j.ultsonch.2007.10.009

21. Cravotto G, Bicchi C, Mantegna S, et al. Extraction of kiwi seed oil: Soxhlet versus four different non-conventional techniques. Natural Product Research 2011; 25(10): 974–981. doi: 10.1080/14786419.2010.524162

22. Chemat F, Tomao V, Virot M. Ultrasound-assisted extraction in food analysis. In: Handbook of Food Analysis Instruments. CRC Press; 2008. pp. 85–103.

23. Babović NV, Petrović SD. Obtaining of the antioxidants by supercritical fluid extraction. Hemijska Industrija 2011; 65(1): 79–86. doi: 10.2298/HEMIND100713064B

24. Mićić V, Yusup S, Begić S, et al. Current trends for industrial applications of supercritical fluids (Serbian). Gazette of Chemists, Technologists and Environmentalists of Republic of Srpska 2015; 11: 65–71.

25. Krulj J, Pezo L, Kojić J, et al. Extraction kinetics modelling of amaranth seed oil supercritical fluid extraction. Journal on Processing and Energy in Agriculture 2021; 25(2): 69–73. doi: 10.5937/jpea25-31249

26. Sun JN, Chen J, Shi YP. Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine. Journal of Chromatography A 2014; 1352: 1–7. doi: 10.1016/j.chroma.2014.05.037

27. Nahar L, Sarker SD. Supercritical fluid extraction. Methods in biotechnology. In: Sarker DS, Latif Z, Gray AI (editors). Natural Products Isolation, 2nd ed. Humana Press Inc.; 2005. pp. 47–76.

28. Conde-Hernández LA, Espinosa-Victoria JR, Trejo A, Guerrero-Beltrán JÁ. CO2-supercritical extraction, hydrodistillation and steam distillation of essential oil of rosemary (Rosmarinus officinalis). Journal of Food Engineering 2017; 200: 81–86. doi: 10.1016/j.jfoodeng.2016.12.022

29. Debenedetti PG. The statistical mechanical theory of concentration fluctuations in mixtures. The Journal of Chemical Physics 1987; 87(2): 1256–1260. doi: 10.1063/1.453308

30. Adil İH, Cetin Hİ, Yener ME, Bayındırlı A. Subcritical (carbon dioxide + ethanol) extraction of polyphenols from apple and peach pomaces, and determination of the antioxidant activities of the extracts. The Journal of Supercritical Fluids 2007; 43(1): 55–63. doi: 10.1016/j.supflu.2007.04.012

31. Palma M, Taylor LT. Extraction of polyphenolic compounds from grape seeds with near critical carbon dioxide. Journal of Chromatography A 1999; 849(1): 117–124. doi: 10.1016/S0021-9673(99)00569-5

32. Murga R, Sanz MT, Beltrán S, Cabezas JL. Solubility of three hydroxycinnamic acids in supercritical carbon dioxide. The Journal of Supercritical Fluids 2003; 27(3): 239–245. doi: 10.1016/S0896-8446(02)00265-6

33. Murga R, Ruiz R, Beltrán S, Cabezas JL. Extraction of natural complex phenols and tannins from grape seeds by using supercritical mixtures of carbon dioxide and alcohol. Journal of Agricultural and Food Chemistry 2000; 48(8): 3408–3412. doi: 10.1021/jf9912506

34. Louli V, Ragoussis N, Magoulas K. Recovery of phenolic antioxidants from wine industry by-products. Bioresource Technology 2004; 92(2): 201–208. doi: 10.1016/j.biortech.2003.06.002

35. Le Flosh F, Tena MT, Rı́os A, Valcárcel M. Supercritical fluid extraction of phenol compounds from olive leaves. Talanta 1998; 46(5): 1123–1130. doi: 10.1016/S0039-9140(97)00375-5

36. Goli AH, Barzegar M, Sahari MA. Antioxidant activity and total phenolic compounds of pistachio (Pistachia vera) hull extracts. Food Chemistry 2005; 92(3): 521–525. doi: 10.1016/j.foodchem.2004.08.020

37. Berna A, Cháfer A, Montón JB. High-pressure solubility data of the system resveratrol (3)+ethanol (2)+CO2 (1). The Journal of Supercritical Fluids 2001; 19(2): 133–139. doi: 10.1016/S0896-8446(00)00088-7

38. Chafer A, Fornari T, Berna A, Stateva RP. Solubility of quercetin in supercritical CO2 + ethanol as a modifier: Measurements and thermodynamic modelling. The Journal of Supercritical Fluids 2004; 32(1–3): 89–96. doi: 10.1016/j.supflu.2004.02.005

39. Sarmento LAV, Machado RAF, Petrus JCC, et al. Extraction of polyphenols from cocoa seeds and concentration through polymeric membranes. The Journal of Supercritical Fluids 2008; 45(1): 64–69. doi: 10.1016/j.supflu.2007.11.007

40. Barba FJ, Zhu Z, Koubaa M, et al. Green alternative methods for the extraction of antioxidant bioactive compounds from winery wastes and by-products: A review. Trends in Food Science & Technology 2016; 49: 96–109. doi: 10.1016/j.tifs.2016.01.006

41. Ashokkumar M. Applications of ultrasound in food and bioprocessing. Ultrasonics Sonochemistry 2015; 25: 17–23. doi: 10.1016/j.ultsonch.2014.08.012

42. Chemat F, Rombaut N, Sicaire AG, et al. Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review. Ultrasonics Sonochemistry 2017; 34: 540–560. doi: 10.1016/j.ultsonch.2016.06.035

43. de Oliveira CF, Giordani D, Lutckemier R, et al. Extraction of pectin from passion fruit peel assisted by ultrasound. LWT—Food Science and Technology 2016; 71: 110–115. doi: 10.1016/j.lwt.2016.03.027

44. Adetunji LR, Adekunle AA, Orsat V, Raghavan V. Advances in the pectin production process using novel extraction techniques: A review. Food Hydrocolloids 2017; 62: 239–250. doi: 10.1016/j.foodhyd.2016.08.015

45. Roselló-Soto E, Galanakis CM, Brnčić M, et al. Clean recovery of antioxidant compounds from plant foods, by-products and algae assisted by ultrasounds processing. Modeling approaches to optimize processing conditions. Trends in Food Science & Technology 2015; 42(2): 134–149. doi: 10.1016/j.tifs.2015.01.002

46. Zinoviadou KG, Galanakis CM, Brnčić M, et al. Fruit juice sonication: Implications on food safety and physicochemical and nutritional properties. Food Research International 2015; 77(4): 743–752. doi: 10.1016/j.foodres.2015.05.032

47. Roselló-Soto E, Koubaa M, Moubarik A, et al. Emerging opportunities for the effective valorization of wastes and by-products generated during olive oil production process: Non-conventional methods for the recovery of high-added value compounds. Trends in Food Science & Technology 2015; 45(2): 296–310. doi: 10.1016/j.tifs.2015.07.003

48. Petigny L, Périno-Issartier S, Wajsman J, Chemat F. Batch and continuous ultrasound assisted extraction of boldo leaves (Peumus boldus Mol.). International Journal of Molecular Sciences 2013; 14(3): 5750–5764. doi: 10.3390/ijms14035750

49. Meullemiestre A, Breil C, Abert-Vian M, Chemat F. Microwave, ultrasound, thermal treatments, and bead milling as intensification techniques for extraction of lipids from oleaginous Yarrowia lipolytica yeast for a biojetfuel application. Bioresource Technology 2016; 211: 190–199. doi: 10.1016/j.biortech.2016.03.040

50. Corbin C, Fidel T, Leclerc EA, et al. Development and validation of an efficient ultrasound assisted extraction of phenolic compounds from flax (Linum usitatissimum L.) seeds. Ultrasonics Sonochemistry 2015; 26: 176–185. doi: 10.1016/j.ultsonch.2015.02.008

51. Azmir J, Zaidul ISM, Rahman MM, et al. Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering 2013; 117(4): 426–436. doi: 10.1016/j.jfoodeng.2013.01.014

52. Ajila CM, Brar SK, Verma M, et al. Extraction and analysis of polyphenols: Recent trends. Critical Reviews in Biotechnology 2011; 31(3): 227–249. doi: 10.3109/07388551.2010.513677

53. Dezhkunov NV, Leighton TG. Study into correlation between the ultrasonic capillary effect and sonoluminescence. Journal of Engineering Physics and Thermophysics 2004; 77: 53–61. doi: 10.1023/B:JOEP.0000020719.33924.aa

54. Khan MK, Abert-Vian M, Fabiano-Tixier AS, et al. Ultrasound-assisted extraction of phenolic compounds (flavanone glycosides) from orange (Citrus sinensis L.) peel. Food Chemistry 2010; 119(2): 851–858. doi: 10.1016/j.foodchem.2009.08.046

55. Audah KA, Manuela K, Amsyir J, et al. Ultrasound-assisted extraction as efficient method for obtaining optimum antioxidant from Mangrove leaves of Rhizophora Mucronata. International Journal of Pharma and Bio Sciences 2018; 9: 47–55.

56. Vinatoru M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrasonics Sonochemistry 2001; 8(3): 303–313. doi: 10.1016/S1350-4177(01)00071-2

57. Virot M, Tomao V, Le Bourvellec C, et al. Towards the industrial production of antioxidants from food processing by-products with ultrasound-assisted extraction. Ultrasonics Sonochemistry 2010; 17(6): 1066–1074. doi: 10.1016/j.ultsonch.2009.10.015

58. Wu J, Lin L, Chau F. Ultrasound-assisted extraction of ginseng saponins from ginseng roots and cultured ginseng cells. Ultrasonics Sonochemistry 2001; 8(4): 347–352. doi: 10.1016/S1350-4177(01)00066-9

59. Luque-Garcı́a JL, Luque de Castro MD. Ultrasound: A powerful tool for leaching. TrAC Trends in Analytical Chemistry 2003; 22(1): 41–47. doi: 10.1016/S0165-9936(03)00102-X

60. Chee KK, Wong MK, Lee HK. Optimization of microwave-assisted solvent extraction of polycyclic aromatic hydrocarbons in marine sediments using a microwave extraction system with high-performance liquid chromatography fluorescence detection and gas chromatography-mass spectrometry. Journal of Chromatography A 1996; 723(2): 259–271. doi: 10.1016/0021-9673(95)00882-9

61. Letellier M, Budzinski H. Microwave assisted extraction of organic compounds. Analusis 1999; 27(3): 259–271. doi: 10.1051/analusis:1999116

62. Camel V. Recent extraction techniques for solid matrices—Supercritical fluid extraction pressurized fluid extraction and microwave-assisted extraction: Their potential and pitfalls. Analyst 2001; 126(7): 1182–1193. doi: 10.1039/B008243K

63. Eskilsson SC, Björklund E. Analytical-scale microwave-assisted extraction. Journal of Chromatography A 2000; 902(1): 227–250. doi: 10.1016/S0021-9673(00)00921-3

64. Venkatesh MS, Raghavan GSV. An overview of microwave processing and dielectric properties of agri-food materials. Biosystems Engineering 2004; 88(1): 1–18. doi: 10.1016/j.biosystemseng.2004.01.007

65. Gfrerer M, Lankmayr E. Screening, optimization and validation of microwave-assisted extraction for the determination of persistent organochlorine pesticides. Analytica Chimica Acta 2005; 533(2): 203–211. doi: 10.1016/j.aca.2004.11.016

66. Wang L, Weller CL. Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology 2006; 17(6): 300–312. doi: 10.1016/j.tifs.2005.12.004

67. Proestos C, Komaitis M. Application of microwave-assisted extraction to the fast extraction of plant phenolic compounds. LWT—Food Science and Technology 2008; 41(4): 652–659. doi: 10.1016/j.lwt.2007.04.013

68. Kaufmann B, Christen P. Recent extraction techniques for natural products: Microwave-assisted extraction and pressurised solvent extraction. Phytochemical Analysis 2002; 13(2): 105–113. doi: 10.1002/pca.631

69. Pan X, Niu G, Liu H. Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves. Chemical Engineering and Processing: Process Intensification 2003; 42(2): 129–133. doi: 10.1016/S0255-2701(02)00037-5

70. Longares-Patrón A, Cañizares-Macías MP. Focused microwaves-assisted extraction and simultaneous spectrophotometric determination of vanillin and p-hydroxybenzaldehyde from Vanilla fragans. Talanta 2006; 69(4): 882–887. doi: 10.1016/j.talanta.2005.11.030

71. Martino E, Ramaiola I, Urbano M, et al. Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction. Journal of Chromatography A 2006; 1125(2): 147–151. doi: 10.1016/j.chroma.2006.05.032

72. Ng LK, Hupé M. Effects of moisture content in cigar tobacco on nicotine extraction: Similarity between Soxhlet and focused open-vessel microwave-assisted techniques. Journal of Chromatography A 2003; 1011(1–2): 213–219. doi: 10.1016/S0021-9673(03)01178-6

73. Santana CM, Ferrera ZS, Padrón MET, Rodríguez JJS. Methodologies for the extraction of phenolic compounds from environmental samples: New approaches. Molecules 2009; 14(1): 298–320. doi: 10.3390/molecules14010298

74. Mirzadeh M, Arianejad MR, Khedmat L. Antioxidant, antiradical, and antimicrobial activities of polysaccharides obtained by microwave-assisted extraction method: A review. Carbohydrate Polymers 2020; 229: 115421. doi: 10.1016/j.carbpol.2019.115421

75. Aparamarta HW, Gunawan S, Husin H, et al. The effect of high oleic and linoleic fatty acid composition for quality and economical of biodiesel from crude Calophyllum inophyllum oil (CCIO) with microwave-assisted extraction (MAE), batchwise solvent extraction (BSE), and combination of MAE–BSE methods. Energy Reports 2020; 6: 3240–3248. doi: 10.1016/j.egyr.2020.11.197

76. Kwiatkowski M, Kravchuk O, Skouroumounis GK, Taylor DK. Response surface parallel optimization of extraction of total phenolics from separate white and red grape skin mixtures with microwave-assisted and conventional thermal methods. Journal of Cleaner Production 2020; 251: 119563. doi: 10.1016/j.jclepro.2019.119563

77. Jesus MS, Genisheva Z, Romaní A, et al. Bioactive compounds recovery optimization from vine pruning residues using conventional heating and microwave-assisted extraction methods. Industrial Crops and Products 2019; 132: 99–110. doi: 10.1016/j.indcrop.2019.01.070

78. Al-Ghouti MA, Khan M, Nasser MS, et al. A novel method for metals extraction from municipal solid waste using a microwave-assisted acid extraction. Journal of Cleaner Production 2021; 287: 125039. doi: 10.1016/j.jclepro.2020.125039




DOI: https://doi.org/10.24294/th.v6i2.3000

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