Nutritional and medicinal values of Mangifera indica L. fruit

Anitha Rajasekaran, Sharmila Soundarapandian

Article ID: 2949
Vol 6, Issue 2, 2023

VIEWS - 357 (Abstract) 128 (PDF)

Abstract


Mangifera indica L. (Mango, Anacardiaceae) is a popular tropical evergreen tree known for its nutritional and medicinal values. It is native to India and Southeast Asia and is known as the “king of fruits” in India and the Philippines. It is considered important in Ayurveda and other systems of medicine. Mango fruit is unique in its taste, colour, aroma, and nutritional qualities. Mangoes are a rich source of polyphenols (Mangiferin, Gallotannins, Quercetin, Isoquercetin, Ellagic acid, Glucogallin, Kaempferol, Catechins, Tannins, and the unique Xanthonoid), phenolic acids (Hydroxybenzoic acids- Gallic, Vanillic, Syringic, Protocatechuic, and p-Hydroxybenzoic acids, Hydroxycinnamic acid derivatives-p-Coumaric, Chlorogenic, Ferulic, and Caffeic acids), flavonoids (β-carotene, α-carotene, β-cryptoxanthin, and Lutein), Vitamin A, Vitamin-B6 (pyridoxine), Vitamin-C, Vitamin-E, Carbohydrates, Amino acids, Organic acids,  micronutrients (Potassium, Copper), fats (Omega-3 and 6 polyunsaturated fatty acids), dietary fibre and certain volatile compounds. About 25 different types of carotenoids have been isolated from the fruit pulp, which contributes to the colour of the fruit. Phytochemical and nutrient content may vary depending on the cultivar. Mangoes possess potential medicinal properties such as antioxidant, gastro-protective, anti-inflammatory, analgesic, immunomodulatory, anti-microbial, and many more. Mango fruit is an abundant source of all essential nutrients and phytochemicals; it could be ultilized as a nutritional supplement in the prevention and cure of several diseases. A comprehensive report on the nutritional and medicinal properties of fruit is presented below.


Keywords


mango; fruit; polyphenols; phenolics; flavonoids; carbohydrates; proteins; fats vitamins; minerals; medicinal properties

Full Text:

PDF


References


1. Mukherjee SK. The mango—Its botany, cultivation, uses and future improvement, especially as observed in India. Economic Botany 1953; 7(2): 130–162. doi: 10.1007/BF02863059

2. Usman M, Fatima B, Jaskani MJ. Breeding in Mango. International Journal of Agriculture & Biology 2001; 3(4): 522–526.

3. Deshpande DJ. A Handbook of Herbal Remedies. Agrobias; 2011.

4. Mehrotra RC, Dilcher DL, Awasthi N. A palaeocene mangifera-like leaf fossil from India. Phytomorphology 1998; 48(1): 91–100.

5. Benitez Blancas FJ, Mercado-Mercado G, Quirós-Sauceda AE, et al. Bioaccessibility of polyphenols associated with dietary fiber and in vitro kinetics release of polyphenols in Mexican ‘Ataulfo’ mango (Mangifera indica L.) by-products. Food & Function 2015; 6(3): 859–868. doi: 10.1039/C4FO00982G

6. Khakimov B, Mongi RJ, Sørensen KM, et al. A comprehensive and comparative GC-MS metabolomics study of non-volatiles in Tanzanian grown mango, pineapple, jackfruit, baobab and tamarind fruits. Food Chemistry 2016; 213: 691–699. doi: 10.1016/j.foodchem.2016.07.005

7. San AT, Joyce DC, Hofman PJ, et al. Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars. Food Chemistry 2017; 221: 613–619. doi: 10.1016/j.foodchem.2016.11.130

8. Rodríguez Pleguezuelo CR, Durán Zuazo VH, Muriel Fernández JL, Franco Tarifa D. Physico-chemical quality parameters of mango (Mangifera indica L.) fruits grown in a Mediterranean subtropical climate (SE Spain). Journal of Agricultural Science and Technology 2012; 14(2): 365–374.

9. Rathore HA, Masud T, Sammi S, Soomro AH. Effect of storage on physico-chemical composition and sensory properties of mango (Mangifera indica L.) variety dosehari. Pakistan Journal of Nutrition 2007; 6(2): 143–148.

10. Lauricella M, Emanuele S, Calvaruso G, et al. Multifaceted health benefits of Mangifera indica L. (Mango): The inestimable value of orchards recently planted in Sicilian rural areas. Nutrients 2017; 9(5): 525. doi: 10.3390/nu9050525

11. Hamdard MS, Rafique MR, Farroq U. Physico-chemical characteristics of various mango, Mangifera indica L. varities. Journal of Agricultural Research 2004; 42(2): 191–199.

12. Leghari MH, Sheikh SA, Memon N. Quality attributes of immature fruit of different mango varieties. Journal of Basic & Applied Sciences 2013; 9: 52–56.

13. Ainslie W. Materia Medica of Hindustan. Neeraj Publishing House; 1813.

14. Achyrya B. Ayurvedic Jadi Buti Rahashya. Divya Prakashana; 2008.

15. Government of India. The ayurvedic pharmacopoeia of India. Available online: http://www.ayurveda.hu/api/API-Vol-2.pdf (accessed on 2 November 2023).

16. Parvez GMM. Pharmacological activities of mango (Mangifera Indica): A review. Journal of Pharmacognosy and Phytochemistry 2016; 5(3): 1–7.

17. Shah KA, Patel MB, Patel RJ, Parmar PK. Mangifera indica (mango). Pharmacognosy Reviews 2010; 4(7): 42–48. doi: 10.4103/0973-7847.65325

18. Palafox-Carlos H, Yahia EM, González-Aguilar GA. Identification and quantification of major phenolic compounds from mango (Mangifera indica, cv. Ataulfo) fruit by HPLC–DAD–MS/MS-ESI and their individual contribution to the antioxidant activity during ripening. Food Chemistry 2012; 135(1): 105–111. doi: 10.1016/j.foodchem.2012.04.103

19. Ghuniyal J. Ethanomedical, chemical, pharmacological, toxicological properties of mangiferaindica: A review. International Journal of Pharma Research & Review 2015; 4(10): 51–64.

20. Siddiq M, Akhtar S, Siddiq R. Mango processing, products and nutrition. In: Siddiq M (editor). Tropical and Subtropical Fruits: Postharvest physiology, Processing and Packaging. John Wiley & Sons; 2012. pp. 277–297. doi: 10.1002/9781118324097

21. Mirfat AHS, Salma I, Razali M. Natural antioxidant properties of selected wild Mangifera species in Malaysia. Journal of Tropical Agriculture and Food Science 2016; 44(1): 63–72.

22. Khoo HE, Ismail A. Determination of daidzein and genistein contents in Mangifera fruit. Malaysian Journal of Nutrition 2008; 14(2): 189–198.

23. Hu K, Dars AG, Liu Q, et al. Phytochemical profiling of the ripening of Chinese mango (Mangifera indica L.) cultivars by real-time monitoring using UPLC-ESI-QTOF-MS and its potential benefits as prebiotic ingredients. Food Chemistry 2018; 256: 171–180. doi: 10.1016/j.foodchem.2018.02.014

24. Claudine M, Augustin S, Christine M, et al. Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition 2004; 79(5): 727–747. doi: 10.1093/ajcn/79.5.727

25. Masibo M, He Q. Major mango polyphenols and their potential significance to human health. Comprehensive Reviews in Food Science and Food Safety 2008; 7(4): 309–319. doi: 10.1111/j.1541-4337.2008.00047.x

26. Berardini N, Fezer R, Conrad J, et al. Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. Journal of Agricultural and Food Chemistry 2005; 53(5): 1563–1570. doi: 10.1021/jf0484069

27. Ribeiro SMR, Barbosa LCA, Queiroz JH, et al. Phenolic compounds and antioxidant capacity of Brazilian mango (Mangifera indica L.) varieties. Food Chemistry 2008; 110(3): 620–626. doi: 10.1016/j.foodchem.2008.02.067

28. Ramirez JE, Zambrano R, Sepúlveda B, Simirgiotis MJ. Antioxidant properties and hyphenated HPLC-PDA-MS profiling of Chilean Pica mango fruits (Mangifera indica L. Cv. piqueño). Molecules 2013; 19(1): 438–458. doi: 10.3390/molecules19010438

29. Schieber A, Ullrich W, Carle R. Characterization of polyphenols in mango puree concentrate by HPLC with diode array and mass spectrometric detection. Innovative Food Science & Emerging Technologies 2000; 1(2): 161–166. doi: 10.1016/S1466-8564(00)00015-1

30. Ajila CM, Aalami M, Leelavathi K, Rao UP. Mango peel powder: A potential source of antioxidant and dietary fiber in macaroni preparations. Innovative Food Science & Emerging Technologies 2010; 11(1): 219–224. doi: 10.1016/j.ifset.2009.10.004

31. Ajila CM, Naidu KA, Bhat SG, Rao UP. Bioactive compounds and antioxidant potential of mango peel extract. Food Chemistry 2007; 105(3): 982–988. doi: 10.1016/j.foodchem.2007.04.052

32. Ajila CM, Rao LJ, Rao UP. Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts. Food and Chemical Toxicology 2010; 48(12): 3406–3411. doi: 10.1016/j.fct.2010.09.012

33. Ocampo ETM, Libron JAMA, Guevarra MLD, Mateo JMC. Phytochemical screening, phenolic acid profiling and antioxidant activity analysis of peels from selected mango (Mangifera spp.) genotypes in the Philippines. Food Research 2020; 4(4): 1116–1124. doi: 10.26656/fr.2017.4(4).025

34. Pacheco-Ordaz R, Antunes-Ricardo M, Gutiérrez-Uribe JA, et al. Intestinal permeability and cellular antioxidant activity of phenolic compounds from mango (Mangifera indica cv. Ataulfo) Peels. International Journal of Molecular Sciences 2018; 19(2): 514. doi: 10.3390/ijms19020514

35. Prasad KN, Hassan FA, Yang B, et al. Response surface optimisation for the extraction of phenolic compounds and antioxidant capacities of underutilised Mangifera pajang Kosterm. peels. Food Chemistry 2011; 128(4): 1121–1127. doi: 10.1016/j.foodchem.2011.03.105

36. Ranasinghe SDAE, Rajapakse CSK. A comparative study on phytochemical screening, antioxidant activity and photoprotective property of ethanolic extracts of peel and pulp of mango (Mangifera indica L. cv. TomEJC). Available online: http://ir.kdu.ac.lk/handle/345/6193 (accessed on 2 November 2023).

37. Ajila CM, Bhat SG, Prasada Rao UJS. Valuable components of raw and ripe peels from two Indian mango varieties. Food Chemistry 2007; 102(4): 1006–1011. doi: 10.1016/j.foodchem.2006.06.036

38. de Lourdes García-Magaña M, García HS, Bello-Pérez LA, et al. Functional properties and dietary fiber characterization of mango processing by-products (Mangifera indica L., cvAtaulfo and Tommy Atkins). Plant Foods for Human Nutrition 2013; 68: 254–258. doi: 10.1007/s11130-013-0364-y

39. Hassan FA, Ismail A, Hamid AA, et al. Characterisation of fibre-rich powder and antioxidant capacity of Mangifera pajang K. fruit peels. Food Chemistry 2011; 126(1): 283–288. doi: 10.1016/j.foodchem.2010.11.019

40. Sogi DS, Siddiq M, Dolan KD. Total phenolics, carotenoids and antioxidant properties of Tommy Atkin mango cubes as affected by drying techniques. LWT—Food Science and Technology 2015; 62(1): 564–568. doi: 10.1016/j.lwt.2014.04.015

41. Abdul Aziz NA, Wong LM, Bhat R, Cheng LH. Evaluation of processed green and ripe mango peel and pulp flours (Mangifera indica var. Chokanan) in terms of chemical composition, antioxidant compounds and functional properties. Journal of the Science of Food and Agriculture 2012; 92: 557–563. doi: 10.1002/jsfa.4606

42. Kim H, Moon JY, Kim H, et al. Antioxidant and antiproliferative activities of mango (Mangifera indica L.) flesh and peel. Food Chemistry 2010; 121(2): 429–436. doi: 10.1016/j.foodchem.2009.12.060

43. Banerjee N, Kim H, Krenek K, et al. Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: Role of the PI3K/AKT pathway and associated microRNAs. Nutrition Research 2015; 35(8): 744–751. doi: 10.1016/j.nutres.2015.06.002

44. Patel GN, Kheni J. Mango seed kernel, a highly nutritious food, should we continue to trash or use? Journal of Pharmacognosy and Phytochemistry 2018; 7(4): 4–7.

45. Shobana V, Rajalakshmi K. Quantitative analysis of primary metabolites in Mangifera indica (unripe mango). Rasayan Journal of Chemistry 2010; 3(3): 597–599.

46. Tokas J, Punia H, Baloda S, Sheokand RN. Mango peel: A potential source of bioactive compounds and phytochemicals. Austin Food Sciences 2020; 5(1): 1035.

47. Yatnatti S, Vijayalakshmi D, Chandru R. Processing and nutritive value of mango seed kernel flour. Current Research in Nutrition and Food Science Journal 2014; 2(3): 170–175. doi: 10.12944/CRNFSJ.2.3.10

48. Ayala-Zavala JF, Vega-Vega V, Rosas-Domínguez C, et al. Agro-industrial potential of exotic fruit byproducts as a source of food additives. Food Research International 2011; 44(7): 1866–1874. doi: 10.1016/j.foodres.2011.02.021

49. Goñi I, Díaz-Rubio ME, Pérez-Jiménez J, Saura-Calixto F. Towards an updated methodology for measurement of dietary fiber, including associated polyphenols, in food and beverages. Food Research International 2009; 42(7): 840–846. doi: 10.1016/j.foodres.2009.03.010

50. Barbosa Gámez I, Caballero Montoya KP, Ledesma N, et al. Changes in the nutritional quality of five Mangifera species harvested at two maturity stages. Journal of the Science of Food and Agriculture 2017; 97(14): 4987–4994. doi: 10.1002/jsfa.8377

51. Chambial S, Dwivedi S, Shukla KK, et al. Vitamin C in disease prevention and cure: An overview. Indian Journal of Clinical Biochemistry 2013; 28(4): 314–328. doi: 10.1007/s12291-013-0375-3

52. Shaikh RN, Agarkar BS, Kshirsagar RB, Bachate AH. Studies on physical, chemical and mineral evaluation of mango (Mangifera indica L.). The Pharma Innovation Journal 2021; 10(6): 446–449.

53. Fowomola MA. Some nutrients and antinutrients contents of mango (Magnifera indica) seed. African Journal of Food Science 2010; 4(8): 472–476.

54. Elegbede JA, Achoba II, Richard H. Nutrient composition of mango (Mangniferaindica) seed kernel from Nigeria. Journal of Food Biochemistry 1995; 19(5): 391–398. doi: 10.1111/j.1745-4514.1995.tb00543.x

55. Gopalan C, Rama Sastri BV, Balasubramanian SC. Nutritive Value of Indian Foods. National Institute of Nutrition, Indian Council of Medical Research; 1993.

56. Tharanathan RN, Yashoda HM, Prabha TN. Mango (Mangifera indica L.), “The king of fruits”—An overview. Food Reviews International 2006; 22(2): 95–123. doi: 10.1080/87559120600574493

57. Bello-Pérez LA, García-Suárez FJL, Agama-Acevedo E. Mango carbohydrates. Food 2007; 1(1): 36–40.

58. Derese S. Guantai EM, Souaibou Y, Kuete V. Mangifera indica L. (Anacardiacea). In: Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases. Elsevier; 2017. pp. 451–483.

59. Othman OC, Mbogo GP. Physico-chemical characteristics of storage-ripened mango (Mangifera indica L.) fruits varieties of Eastern Tanzania. Tanzania Journal of Science 2009; 35: 57–65.

60. Lalel HJD, Singh Z, Tan SC. The role of ethylene in mango fruit aroma volatiles biosynthesis. The Journal of Horticultural Science and Biotechnology 2003; 78(4): 485–496. doi: 10.1080/14620316.2003.11511653

61. Jahurul MHA, Zaidul ISM, Ghafoor K, et al. Mango (Mangifera indica L.) by-products and their valuable components: A review. Food Chemistry 2015; 183: 173–180. doi: 10.1016/j.foodchem.2015.03.046

62. Deshpande AB, Hemangi GC, Pranjali SO, et al. Data on changes in the fatty acid composition during fruit development and ripening of three mango cultivars (Alphonso, Pairi and Kent) varying in lactone content. Data in Brief 2016; 9: 480–491. doi: 10.1016/j.dib.2016.09.018

63. Vallarino JG, Pott DM, Cruz-Rus E, et al. Identification of quantitative trait loci and candidate genes for primary metabolite content in strawberry fruit. Horticulture Research 2019; 6: 4. doi: 10.1038/s41438-018-0077-3

64. Shahidi F, Janitha PK, Wanasundara PD. Phenolic antioxidants. Critical Reviews in Food Science & Nutrition 1992; 32(1): 67–103. doi: 10.1080/10408399209527581

65. Kalpna R, Mital K, Sumitra C. Vegetable and fruit peels as a novel source of antioxidants. Journal of Medicinal Plants Research 2011; 5(1): 63–71.

66. Zhu XM, Song JX, Huang ZZ, et al. Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro. Acta Pharmacologica Sinica 1993; 14(5): 452–454.

67. Zheng MS, Lu ZY. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Acta Pharmacologica Sinica 1989; 103: 160–165.

68. Stoilova I, Gargova S, Stoyanova A, Ho L. Antimicrobial and antioxidant activity of the polyphenol mangiferin. Herb Polonica 2005; 51: 37–44.

69. Engels C, Schieber A, Gänzle MG. Inhibitory spectra and modes of antimicrobial action of gallotannins from mango kernels (MangiferaIndica L.). Applied and Environmental Microbiology 2011; 77(7): 2215–2223. doi: 10.1128/AEM.02521-10

70. Vega-Vega V, Silva-Espinoza BA, Cruz-Valenzuela MR, et al. Antimicrobial and antioxidant properties of byproduct extracts of mango fruit. Journal of Applied Botany and Food Quality 2013; 86(1): 205–211. doi: 10.5073/JABFQ.2013.086.028

71. El-Desoukey RMA, Alijor NM, Alaotibi AD. The phytochemical and antimicrobial effect of mango (Mangifera Indica L.) peel extracts on some animal pathogens as eco-friendly. Acta Scientific Microbiology2020; 3(4): 34–39.

72. Sairam K, Hemalatha S, Kumar A, et al. Evaluation of anti-diarrhoeal activity in seed extracts of Mangifera indica. Journal of Ethnopharmacology 2003; 84(1): 11–15.

73. Alkizim FO, Matheka D, Abdulrahman FK, Muriithi A. Inhibitory effect of Mangifera indica on gastrointestinal motility. Medicinal Chemistry and Drug Discovery 2012; 2(1): 9–16.

74. Dhananjaya BL, Shivalingaiah S. The anti-inflammatory activity of standard aqueous stem bark extract of Mangifera indica L. as evident in inhibition of Group IA sPLA2. Anais da Academia Brasileira de Cienccias 2016; 88(1): 197–209. doi: 10.1590/0001-3765201620140574

75. Impellizzeri D, Talero E, Siracusa R, et al. Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice. British Journal of Nutrition 2015; 114(6): 853–865. doi: 10.1017/S0007114515002597

76. Duricova D. What can we learn from epidemiological studies in inflammatory bowel disease? Digestive Diseases 2017; 35(1–2): 69–73. doi: 10.1159/000449086

77. Márquez L, Pérez-Nievas BG, Gárate I, et al. Anti-inflammatory effects of Mangifera indica L. extract in a model of colitis. World Journal of Gastroenterology 2010; 16(39): 4922–4931. doi: 10.3748/wjg.v16.i39.4922

78. Kim H, Banerjee N, Ivanov I, et al. Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Molecular Nutrition & Food Research 2016; 60(9): 1912–1923. doi: 10.1002/mnfr.201501008

79. Sharma SR, Dwivedi SK, Swarup D. Hypoglycaemic potential of Mangifera indica leaves in rats. International Journal of Pharmacognosy 1997; 35(2): 130–133. doi: 10.1076/phbi.35.2.130.13276

80. Aderibigbe AO, Emudianughe TS, Lawal BAS. Antihyperglycaemic effect of Mangifera indica in rat. Phytotherapy Research 1999; 13(6): 504–507. doi: 10.1002/(SICI)1099-1573(199909)13:6<504::AID-PTR533>3.0.CO;2-9

81. Perpétuo GF, Salgado JM. Effect of mango (Mangifera indica, L.) ingestion on blood glucose levels of normal and diabetic rats. Plant Foods for Human Nutrition 2003; 58: 1–12. doi: 10.1023/B:QUAL.0000040336.38013.83

82. Gondi M, Prasada Rao UJS. Ethanol extract of mango (Mangifera indica L.) peel inhibits α-amylase and α-glucosidase activities, and ameliorates diabetes related biochemical parameters in streptozotocin (STZ)-induced diabetic rats. Journal of Food Science and Technology 2015; 52(12): 7883–7893. doi: 10.1007/s13197-015-1963-4

83. Kim H, Kim H, Mosaddik A, et al. Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh. Food Chemistry 2012; 133(2): 416–422. doi: 10.1016/j.foodchem.2012.01.053

84. Corrales-Bernal A, Amparo Urango L, Rojano B, Maldonado ME. In vitro and in vivo effects of mango pulp (Mangifera indica cv. Azucar) in colon carcinogenesis (Spanish). Archivos Latinoamericanos de Nutrición 2014; 64(1): 16–23.

85. Abdullah AS, Mohammed AS, Rasedee A, et al. Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract. BMC Complementary Medicine and Therapies 2015; 9(15): 45. doi: 10.1186/s12906-015-0575-x

86. Oka K, Saito F, Yasuhara T, Sugimoto A. A study of cross-reactions between mango contact allergens and urushiol. Contact Dermatitis 2004; 51(5–6): 292–296. doi: 10.1111/j.0105-1873.2004.00451.x

87. Percival SS, Talcott ST, Chin ST, et al. Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts. The Journal of Nutrition 2006; 136(5): 1300–1304. doi: 10.1093/jn/136.5.1300

88. van de Venter M, du Plessis-Stoman D, du Preez JGH. Combination treatment with oxaliplatin and mangiferin causes increased apoptosis and downregulation of nfîšb in cancer cell lines. African Journal of Traditional, Complementary and Alternative Medicines 2011; 8(2): 177–184.

89. Shoji K, Tsubaki M, Yamazoe Y, et al. Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells. Archives of Pharmacal Research 2011; 34: 469–475. doi: 10.1007/s12272-011-0316-8

90. Pithayanukul P, Leanpolchareanchai J, Saparpakorn P. Molecular docking studies and anti-snake venom metalloproteinase activity of Thai mango seed kernel extract. Molecules 2009; 14(9): 3198–3213. doi: 10.3390/molecules14093198

91. Nithitanakool S, Pithayanukul P, Bavovada R. Antioxidant and hepatoprotective activities of Thai mango seed kernel extract. Planta Medica 2009; 75(10): 1118–1123. doi: 10.1055/s-0029-1185507




DOI: https://doi.org/10.24294/th.v6i2.2949

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This site is licensed under a Creative Commons Attribution 4.0 International License.