Recent research efforts have increasingly concentrated on creating innovative biomaterials to improve bone tissue engineering techniques. Among these, hybrid nanomaterials stand out as a promising category of biomaterials. In this study, we present a straightforward, cost-efficient, and optimized hydrothermal synthesis method to produce high-purity Ta-doped potassium titanate nanofibers. Morphological characterizations revealed that Ta-doping maintained the native crystal structure of potassium titanate, highlighting its exciting potential in bone tissue engineering.TRANSLATE with xEnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian   TRANSLATE with COPY THE URL BELOW BackEMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack

nanosynthesis; titanate nanofiber; bone scaffold; tantalum dopant

1. Benedini L, Laiuppa J, Santillán G, et al. Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity. Materials Science and Engineering: C 2020; 115: 111101. doi: 10.1016/j.msec.2020.111101

2. Min Q, Liu J, Zhang Y, et al. Dual network hydrogels incorporated with bone morphogenic protein-7-loaded hyaluronic acid complex nanoparticles for inducing chondrogenic differentiation of synovium-derived mesenchymal stem cells. Pharmaceutics 2020; 12(7): 613. doi: 10.3390/pharmaceutics12070613

3. Nie L, Deng Y, Li P, et al. Hydroxyethyl chitosan-reinforced polyvinyl alcohol/biphasic calcium phosphate hydrogels for bone regeneration. ACS Omega 2020; 5(19): 10948–10957. doi: 10.1021/acsomega.0c00727

4. Oudadesse H, Najem S, Mosbahi S, et al. Development of hybrid scaffold: Bioactive glass nanoparticles/chitosan for tissue engineering applications. Journal of Biomedical Materials Research Part A 2020; 109(5): 590–599. doi: 10.1002/jbm.a.37043

5. Maji K, Dasgupta S, Bhaskar R, et al. Photo-crosslinked alginate nano-hydroxyapatite paste for bone tissue engineering. Biomedical Materials 2020; 15(5): 055019. doi: 10.1088/1748-605x/ab9551

6. Wu T, Li B, Wang W, et al. Strontium-substituted hydroxyapatite grown on graphene oxide nanosheet-reinforced chitosan scaffold to promote bone regeneration. Biomaterials Science 2020; 8(16): 4603–4615. doi: 10.1039/d0bm00523a

7. Zhang B, Li J, He L, et al. Bio-surface coated titanium scaffolds with cancellous bone-like biomimetic structure for enhanced bone tissue regeneration. Acta Biomaterialia 2020; 114: 431–448. doi: 10.1016/j.actbio.2020.07.024

8. Yang L, Gao C, Wei D, et al. Nanotechnology for treating osteoporotic vertebral fractures. International Journal of Nanomedicine 2015; 10: 5139–5157. doi: 10.2147/ijn.s85037

9. Saravanan S, Vimalraj S, Anuradha D. Chitosan based thermoresponsive hydrogel containing graphene oxide for bone tissue repair. Biomedicine & Pharmacotherapy 2018; 107: 908–917. doi: 10.1016/j.biopha.2018.08.072

10. Mohammadi M, Mousavi Shaegh SA, Alibolandi M, et al. Micro and nanotechnologies for bone regeneration: Recent advances and emerging designs. Journal of Controlled Release 2018; 274: 35–55. doi: 10.1016/j.jconrel.2018.01.032

11. Aldaadaa A, Al Qaysi M, Georgiou G, et al. Physical properties and biocompatibility effects of doping SiO2 and TiO2 into phosphate-based glass for bone tissue engineering. Journal of Biomaterials Applications 2018; 33(2): 271–280. doi: 10.1177/0885328218788832

12. Hashemi A, Ezati M, Mohammadnejad J, et al. Chitosan coating of TiO2 nanotube arrays for improved metformin release and osteoblast differentiation. International Journal of Nanomedicine 2020; 15: 4471–4481. doi: 10.2147/ijn.s248927

13. Liang F, Zhou L, Wang K. Apatite formation on porous titanium by alkali and heat-treatment. Surface and Coatings Technology 2003; 165(2): 133–139. doi: 10.1016/s0257-8972(02)00735-1

14. Frandsen CJ, Brammer KS, Noh K, et al. Tantalum coating on TiO2 nanotubes induces superior rate of matrix mineralization and osteofunctionality in human osteoblasts. Materials Science and Engineering: C 2014; 37: 332–341. doi: 10.1016/j.msec.2014.01.014

15. Dong W, Cogbill A, Zhang T, et al. Multifunctional, catalytic nanowire membranes and the membrane-based 3D devices. The Journal of Physical Chemistry B 2006; 110(34): 16819–16822. doi: 10.1021/jp0637633

16. Dong W, Zhang T, Epstein J, et al. Multifunctional nanowire bioscaffolds on titanium. Chemistry of Materials 2007; 19(18): 4454–4459. doi: 10.1021/cm070845a

17. Hwang C, Park S, Kang IG, et al. Tantalum-coated polylactic acid fibrous membranes for guided bone regeneration. Materials Science and Engineering: C 2020; 115: 111112. doi: 10.1016/j.msec.2020.111112

18. Marins NH, Lee BEJ, e Silva RM, et al. Niobium pentoxide and hydroxyapatite particle loaded electrospun polycaprolactone/gelatin membranes for bone tissue engineering. Colloids and Surfaces B: Biointerfaces 2019; 182: 110386. doi: 10.1016/j.colsurfb.2019.110386

19. Zhang J, Huang D, Liu S, et al. Zirconia toughened hydroxyapatite biocomposite formed by a DLP 3D printing process for potential bone tissue engineering. Materials Science and Engineering: C 2019; 105: 110054. doi: 10.1016/j.msec.2019.110054

20. Inui T, Haneda S, Sasaki M, et al. Enhanced chondrogenic differentiation of equine bone marrow-derived mesenchymal stem cells in zirconia microwell substrata. Research in Veterinary Science 2019; 125: 345–350. doi: 10.1016/j.rvsc.2019.07.005

21. Cole P, Tian Y, Thornburgh S, et al. Hydrothermal synthesis of valve metal Zr-doped titanate nanofibers for bone tissue engineering. Nano and Medical Materials 2023; 3(2): 249. doi: 10.59400/nmm.v3i2.249

22. Xiao Y, Tian Y, Zhan Y, Zhu J. Degradation of organic pollutants in flocculated liquid digestate using photocatalytic titanate nanofibers: Mechanism and response surface optimization. Frontiers of Agricultural Science and Engineering 2023. doi: 10.15302/j-fase-2023503

23. Shannon RD. Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides. Acta Crystallographica Section A 1976; 32(5): 751–767. doi: 10.1107/s0567739476001551

24. Yuan ZY, Zhang XB, Su BL. Moderate hydrothermal synthesis of potassium titanate nanowires. Applied Physics A 2004; 78(7): 1063–1066. doi: 10.1007/s00339-003-2165-x

25. Wu Z, Yoshimura M. The formation of pyrochlore potassium tantalate thin films by soft solution processing. Thin Solid Films 2000; 375(1–2): 46–50. doi: 10.1016/s0040-6090(00)01178-0

26. Alizadeh A, Moztarzadeh F, Ostad SN, et al. Synthesis of calcium phosphate-zirconia scaffold and human endometrial adult stem cells for bone tissue engineering. Artificial Cells, Nanomedicine, and Biotechnology 2014; 44(1): 66–73. doi: 10.3109/21691401.2014.909825

27. Jin S, Yu J, Zheng Y, et al. Preparation and characterization of electrospun PAN/PSA carbonized nanofibers: Experiment and simulation study. Nanomaterials 2018; 8(10): 821. doi: 10.3390/nano8100821

28. Wang X, Liu SJ, Qi YM, et al. Behavior of potassium titanate whisker in simulated body fluid. Materials Letters 2014; 135: 139–142. doi: 10.1016/j.matlet.2014.07.145

29. Kokubo T, Yamaguchi S. Novel bioactive titanate layers formed on Ti metal and its alloys by chemical treatments. Materials 2009; 3(1): 48–63. doi: 10.3390/ma3010048