Advances in Synthesis and Application of Nanometer Drug Carriers

Jianping Wu, Keming Wang, Yuquan Peng


The main reason for the formation of nano-biotechnology is due to the penetration of nanotechnology in the biological field, nanotechnology research center is the study of nano-drug carrier. Nano-drug system targeted drug delivery to achieve drug release, increase the insoluble drugs and peptide drug bio-efficiency, reduce the toxicity and application of drugs and other aspects of the development of good prospects, and thus become one of the key research in recent years’ field. Synthesis and application of nanometer drug carriers this review is presented in recent years and its application to provide a comprehensive basis for the treatment process. Describes the nature and preparation of nano-drug carrier methods, in recent years, people have been widely concerned by scholars. Compared with the nano-drug delivery, the general pharmaceutical cannot have to extend the role of drugs, strong efficacy, and the advantages of small drug response. Nano-materials, the specific surface area, surface activity, high catalytic efficiency, surface active center, adsorption capacity and other characteristics, which has many excellent features and new features.

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Lu W, i ZhangY, TanYZ, et a1. Cationic albumin-conjugated Pegylated nanoparticles as novel drug carrier forbrain delivery [J]. J Controlled Release, 2005, 107 (3): 428.

CX. Yi, JN. Yu, XM. Xu. Nano drug carrier in the development of traditional Chinese medicine Jing of the application [J]. Chinese Journal of Traditional Chinese Medicine, 2008,33 (16): 1936-1940.

Kreuter J, Hekmatara T, Dreis S, et al. Covalent attachment of Apo lipoprotein A-I and Apo lipoprotein B-lOO to albumin nanoparticles enables drug transport into the brain l-J]. J Controlled Release, 2007, 118 (1): 54.

Yang, WL. Lu, Q. Zhang. Advances in Liposomal and Nanoparticle Drug Delivery Systems EJ3. Chinese Journal of Medical Science, 2006,28 (4): 583-589.

BP. Yang, WQ. Ouyang, XJ. Wu. Wait. The quality evaluation of resveratrol Nano emulsion [J]. Journal of Northwest Agricultural Sciences 2008,17 (2): 20-23.

HY. Lin, XY. Lu, N. Tang, et al. Preparation of Vincristine PEGPE Micelles and its inhibition on breast cancer cell growth [J3]. Biochemistry and Biophysical Advances, 2006, 33 (8): 769-774.

Jacobs C, Kayser O, Muller RH. Production and characterization of mucoadhesive nano suspensions for the formulation of bupravaquone [J]. Int J Pharm, 2001, 214: 3.

Guo, SQ. Deng. Application of nanotechnology in pharmacy research progress. Foreign Medical Antibiotics Volume, 2004,25 (5); 233-237.

FangC, ShiB, PeiYY, etal. In vivo tumor targeting of tumor necrosis factor2 alpha2 loaded stealth nanoparticles: effect of

Me2PEG molecular weight aD particle size [J]. Eur J Pharm Sci, 2006,27 (1): 27236

Guangdong Medicine, 2009,30 (1): 17219 (in Chinese with English abstract) [J].

WL. Lu, JX. Guo, QN. Ping. Preparation and quality of breviscapine liposomes [J]. Chinese Journal of Natural Medicines, 2004, 2, (5)

Y. Gu, Y. Shi, SQ. Zhang, et al. Preparation and quality evaluation of emodinnano-liposomes [J]. Journal of the Fourth Military Medical University, 2003, 24 (5).

C hauvierre C, V authier C, Labarre Detal. Evaluation of the surface properties of dextran - coated poly (Isobutylcyanoacry late) nanoparticles by spin-labelling coupled with electron resonance spectroscopy [J]. Colloid Polym Sci, 2004, 282: 1016 -1025.

L. Wang. Reverse micro emulsion polymerization and preparation of magnetic polymer nanoparticles [D]. Shanghai: Fudan University, 2001.

YQ. Liao. Methyl methacrylate emulsion and micro emulsion ultrasonic irradiation initiation polymerization and synthesis with inorganic nanoparticles [D]. Chengdu: Sichuan University, 2001.

CX. Li, ZH. Wang. Application of ultrasonic technology in preparation of nanomaterials [J]. Chemical Bulletin, 2001, 5: 268 - 271.

Pilar Calvo, Jose' L. Vidla-Jato, Maria JALonso. Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers [J]. International Journal of Pharmaceutics, 1997, 53: 41 -50.

Soma CE, Dubernet C, Baratt G. Ability of doxorubicin-loaded nanoparticles to overcome multidrug resistance of tumor cells after their capture by macrophages. Pharm Research. 1999; 16 (11): 1710.

Kou G, Gao J. Wang H. Preparation and characterization of paditaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody. J Biochem Mol Biol. 2007; 40 (5): 731-739.

SC. Yang, JW. Zhu, BW. Liang, et al. Camptothecin solid lipid nanoparticles [J]. Chinese Journal of Pharmacology, 1999,34 (2): 146-150.

Yue G Z, Qiu Q, Gao B, et a1. Generation of continuous and pulsed diagnostic imaging X-ray radiation using a carbon-nanotube-based field-emission cathode [J]. Appl Phys Lett, 2002, 81: 355

DZ. Liu. Modern ray detection technology. Beijing: China Standard Press, 999.42

Helga E. De Vries et al. Blood-brain barrier in neuroinf lammatorydiseases [J]. Pharmacol Rev, 1997, 49: 143-155

S. E. Gelperina, Z. Smmirnova, A.S. Khalanskiy, IN. Skidan, AIBobruskin, J. Kreuter. Chemotherapy of brain tumours using doxoru bicin bound to polysorbate 80-coated nanoparticles. Proceedings of the 3rd World Meeting APV / APGI, Berlin, 2000, 3/6th April 2000, 441-442

D. J. Selkoe. Alzheimer's disease: genes, proteins and therapy. Phys Rev. 2001, 81: 741-766



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