HOMEOSTASIS CHANGE IN THE SMALL INTESTINE WITH DISTURBED REGIONAL BLOOD FLOW IN EARLY POSTNATAL ONTOGENESIS
Vol 5, Issue 1, 2022
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Abstract
Objective: A study of the ischemic damage course and regeneration in the small intestine with disturbed regional blood flow in early postnatal ontogenesis.
Materials and Methods: The experiments were carried out on 30 puppies at the age from 1 to 4 weeks. The state of regional blood flow in the ischemic area of the small intestine was investigated by blood filling of tissues, metabolism - by redox potential, oxygen pressure and diffusion oxygen coefficient, lipid peroxidation activity and catalase activity. Database formation and statistical calculations were performed using the applied programmes "Microsoft Excel", "ANOVA" for "Windows".
Results: The performed research showed that in animals of early age pronounced microcirculatory disorders were observed. About this evidenced significant tissue bloodfilling in the ischemic region of the small intestine. Essential disorder of the blood supply in the organ naturally led to a pronounced fall in the redox potential, the oxygen pressure, and the diffusion oxygen coefficient in the tissues.On a level with the disturbances in the electrogenesis and tissue oxygenation, we found a significant diminution in their antioxidant capacity, as evidenced by a pronounced increase in lipid peroxidation and a decrease in catalytic activity. Insufficient oxygen supply of tissues caused the development of irreversible changes in the intestinal wall, the disorder of the organ motility with frequent appearance of small intestinal intussusception.
Conclusions: A significant disturbance of the small intestine blood supply at the early age, caused by an operating trauma, leads to a pronounced decrease in electrical activity and oxygenation of the organ tissues, accompanied by marked metabolic disorders.
Oxygen starvation of tissues in the ischemic region of the small intestine at the early age contributes to the development of irreversible changes in the intestinal wall, and frequent disruption of the regeneration process in this area.
Keywords: small intestine; local ischemia; early age
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1. Stallion A, Kou TD, Latifi SQ, et al. Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation. Journal of Pediatric Surgery, 2005. 40 (3): 470 – 477.
2. Li Y-Sh, Wang Zh-X, Li C, et al. Proteomics of ischemia/reperfusion injury in rat intes-tine with and without ischemic postconditioning. Journal of Surgical Research, 2010. 164 (1): e173 – e180.
3. Ding W, Wu X, Gong G, et al. Establishment of an acute superior mesenteric artery in-jury model for damage control surgery. Journal of Surgical Research, 2009. 152 (2): 249-257.
4. Petrat F, Rönn Th, de Groot H Protection by pyruvate infusion in a rat model of severe intestinal ischemia-reperfusion injury. Journal of Surgical Research, 2011. 167 (2): e93 – e101.
5. Markos`yan SA Morphofunctional assessment of intestinal wound reparation at different ages. Bulletin of Experimental Biology and Medicine, 1998. 8: 234-236.
6. Derikx JPM, Matthijsen RA, de Bruine AP A New Model to Study Intestinal Ischemia-Reperfusion Damage in Man. Journal of Surgical Research, 2011. 166 (2): 222 – 226.
7. Markos'yan SA, Lysyakov NM, Ismail Alawal MA, et al. Effect of intraoperative heparin administration on some indices of the blood coagulatory-lytic system in the ischemic region of the small intestine with anastomosis. Bulletin of Experimental Biology and Medicine, 2014. 156 (6): 753-755.
DOI: https://doi.org/10.24294/as.v1i2.519
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