Sinus histiocytosis with massive lymphadenopathy: a case report and literature review

Jianying Feng, Tiantian Han, Fuyong Jiao


Sinus histiocytosis with with massive lymphadenopathy is a benign lymphoproliferative disorder.In 1969, Rosai and Dorfman[1] made detailed research on it, so it was also called Rosai DorfnlRn disease (rosai.dorfmandisease, RDD).The clinical manifestations were fever, neck lymph node enlargement, leukocytosis and high gamma globulin.Histopathological findings showed that lymph node involvement was present in group RDD, and the infiltration of the cells was predominant, especially the phagocytosis of the histiocytic cells.About 43% of RDD patients have lymph node involvement in [2], in which the skin is the most common extranodal organs involved.About 10% of patients with skin damage, skin rash and morphological diversity, is easy to be misdiagnosed.In this paper, through the analysis of a case of RDD and EB virus infection, in clinical in patients with special infection can be early detection and treatment.


Sinus; histiocytosis ; lymphadenopathy

Full Text:



Rosai J,Dodman RF.Sinus histiocytosis with massive lymphadenopathy.A newly recoized benign clinicopathological entity [J].ArchPath01.1969.87(1):63—70.

Brenn T.Calonje E.Granter S R.Cutane-Otis rosai-dorfman disease is a distinct clinical entity [J].Am J Dermatopath01.2002.24(5):385—391.

M a g g i U ,R u s s o R , C o n t e G , e t al .Fi l m i na n t m ul t i o r g an f a i l u red u e t o v ar i c e l l a z st e r v i ru s a n d HH V6 i n a n i m m u n o c o m p e t e n t ad u lt p a t i e nt , a n d a n h ep a t i a [ J ] .T r an s p l a n t P ro c ,2011 ,43(4) :1184 -11186 .

S t ro n g M J , O ′G ran d y T , Li nZ , e t a l .E p s t ei n -B a r r v i ru s a nd hum a n h e rp esv i ru s 6 d e t ec t i o n i n a n o n -H o d g k i n ′s di ffu s e l a r g e B -ce l l l y m p ho m a c o h o rt b y u s i n g R N A s eq u e n c i n g [ J ] .V i ro l ,

,87(23) :13059 -13062 .

Or t on n e N , F i ll e t A M , K o s u g e H , e t a l .C u t an e o u s D e s t o m b e s -R o s a i -D o rf m a n d i s ea s e : a b s e n c e o f de t e c ti o n o f H H V -6 a n d

H H V -8 i n sk i n [ J ] .J C u t a n P a t h o l ,2002 ,29 (2) :113 -118 .

N e i l V , M a r k R , H a k a n C , e t a l .M u t a t io n s i n S L C29 A3 , e n c o d i n g a n e q u i li b r at iv e n u c l e o s i d e t r an s p o r t e r E N T3 , c a u se a f a m i li a l h i s t i o c y to si s sy n d r o m e( f a i s a l a b a d hi s t i o c y t os i s ) a n d f a m -i li a l ro s ai -D o rf m a n d i s e a se [ J ].P L o S G e n e t ,2010 ,6(2):el000833

甘梅富, 周涛, 余心如, 等.淋巴结外R o s a i -D o r f m a n 病[ J ] .中华病理学杂志,2005 ,34 (3):137 -139 .

Saboo SS,Jagannathan JP,Krajewski KM,et a1.Symptomatic extranodal Rosai—Dorfman disease treatedwith steroids,radiation, and surgery[J].J Clin Oncol,201l,29(31):e772一e775.DOI:10.1200/JC0.2011.36.9967.

Sandoval-Sus JD,Sandoval-LeonAC,Chapman JR,et a1.Rosai-Doffman disease of the central nervous

system:report of 6 cases and review of the literature [J]. Medicine (Baltimore), 2014, 93 (3):165—175.DOI:10.1097,MD.00000000clo000030.

Forest F,N’guyen AT,Fesselet J,et a1.Meningeal Rosai—Dorfman disease mimicking meningioma[J].Ann Hematol,2014,93(6):937.940.DOI:lO.1007/s00277一013—1994—8.



  • There are currently no refbacks.

Copyright (c) 2018 Jianying Feng

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.