Abstract I am very glad to present to the readers of “Medical Imaging Process & Technology” journal the forthcoming second edition of our book “QSAR-mapping and SBGN-mapping for Biological Samples (Lecture Course and Special Practicum)”, which is actually an introduction to the novel microscopic imaging approaches for numerous biomedical applications. It is possible to imagine that imaging and morphology of biological structures is not a rigorous mapping of different “material points” and structures in the field of view (or ROI’s), because the living state of the sample is a complex of many spatiotemporal dynamic processes. 

Abstract Modulation transfer function (MTF) is a well known and widely accepted method for evaluating the spatial resolution of a digital radiographic imaging system. In the present study our aim was to evaluate the MTF obtained from CBCT and micro-CT images. A cylinder shaped phantom designed for slanted-edge method was scanned by a CBCT device at a 100 µm isometric voxel size and by a micro-CT device at a 20 µm isometric voxel size, simultaneously. The MTF curves were calculated and the mean spatial resolutions at 10% MTF were 3.33 +  0.29 lp/mm in the case of CBCT images and 13.35 +  2.47 lp/mm in the case of micro-CT images. The values showed a strong positive correlation regarding the CBCT and the micro-CT spatial resolution values, respectively. Our results suggests that CBCT imaging devices with a voxel size of 100 µm or below might aid the validation of fine anatomical structures and allowing the opportunity for reliable micromorphometric examinations