“Langerhan Cell Histiocytosis –Review Of Literature”

Ashutosh Jaysing Thorat, Pawan Vilasrao Dawane

Article ID: 637
Vol 1, Issue 2, 2018, Article identifier:

VIEWS - 804 (Abstract) 173 (PDF)


Background: Langerhans cell histiocytosis is a relatively rare unique disease process characterized by an abnormal proliferation of immature dendritic cells usually affecting children and young adults.

Discussion:  Histiocytosis are rare diseases of great biological variability and a wide range of clinical manifestations. The first manifestations of LCH may occur in the oral cavity may vary from a continuous gingival infection or a dental abscess to necrotizing ulcerating defects or a painful jaw swelling.The criteria  for diagnosis of LCH includes identification of the characteristic clinical features histopathological, Immunohistochemical findings. Various treatment modalities has been adopted including wide surgical excision along with radiotherapy,chemotherapy ,isolated radiotherapy and use of alkalizing agents.

Keywords- Langerhans cell histiocytosis, Histiocytosis X , Osteolysis of skull

Full Text:



Vlasta Merglova, Daniel Hrusak ,Ludmila Boudova, PetrMukensnabl, Eva Valentova, LuborHosticka (2014) Langerhans cell histiocytosis in childhood e Review, symptoms in the oral cavity, differential diagnosis and report of two cases Journal of Cranio-Maxillo-Facial Surgery 42 93e100

. Lichtenstein L (1953) Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol Jul;56(1):84-102.

. Nezelof C, Basset F, Rousseau MF (1973) Histiocytosis X histogenetic arguments for a Langerhans cell origin. Biomedicine Sep;18(5):365-71

.Osband ME, Lipton JM, Lavin P, et al. (1981 )Histiocytosis X: Demonstration of abnormal immunity, T-cell histamine H2 receptor deficiency, and successful treatment with therapy extract. N Engl J Med;304:146-53.

.I_lknurHaberalCan ,Aydın Kurt , Elif O ̈zer , Neriman Sarı , ErdalSamim (2005) Mandibular manifestation of Langerhans cell histiocytosis in children Oral Oncology EXTRA 41, 174–177

. Lunardi, P.. Farah, J.O., Qhaso, R, et al. (1996) Primary eosinophilic granuloma invading the skull base: case report and critical review of the literature. Tumori; 82: 397-400

. Subramanian, N., Krishnakumar, S., Babu, K., Mohan, R., Lakshmi, K.S., Biswas, J. (2004) Adult onset Langerhans cell his- tiocytosis of the orbit--a case report. Orbit.; 23: 99-103

. Hartman KS (1980) Histiocytosis X: a review of 114 cases with oral involvement. Oral Surgery Oral Medicine Oral Pathology;49(1):38-54.

. Unlü F, Gürses N, Seçkin T, Unal T. (1997) Multifocal eosinophilic granuloma with sequential periodontitis like lesions. J Clin Periodontol Jun;24(6):384-7.

. Moghadam BK, Saedi S, Gier RE. (1991) Adult onset multifocal histiocytosis X presenting as a perio- dontal problem. J Oral Maxillofac Surg Apr;49(4):417-9.

. Hanapiah F, Yaacob H, Ghani KS, Hussin AS. (1993) Histiocytosis X: evidence for a genetic etiology. J Nihon UnivSch Dent Sep;35(3):171-4.

.Vlasta Merglová , Daniel Hrusak ,LudmilaBoudova , PetrMukensnabl , Eva Valentova , Lubor Hosticka. (2014) Langerhans cell histiocytosis in childhood e Review, symptoms in theoral cavity, differential diagnosis and report of two cases. Journal of Cranio-Maxillo-Facial Surgery 42 93e100

.Gorsky M, Silverman S, Lozada F, KushnerJH (1983).Histiocytosis X: Occurrence and oral involvement in six adolescent and adult patients. Oral Surg Oral Med Oral Pathol;55:24-8.

.Sigala JL, Silverman S, Brody HA, Kushner JH. (1972) Dental involvement in histiocytosis. Oral Surgery Oral Medicine Oral Pathology;33:42-8

. Ennis JT, Whitehouse G, Ross FGM. et al; (1973) The radiology of the bone changes in histiocytosis X. Ctin Radio!;24;212- 220.

. Artii Z, Gorsky M, Raviv M (1989) Periodontal manifestations of adult onset of Histiocytosis X. J Periodontol ;60;57-55.

BroadbentV,GadnerH,KompDM,LadischS. (1989) Histiocytosis syndromes in childrens:II.Approach to the clinical & laboratory evaluation with Langerhans cell histiocytosis.Clinical Writing Group Of the Histocyte Society .Med PediatrOncol;17(6):492-95

. Roy Choudhury A, Shah N, Parkash H, Mukhopadhyay S, Chopra P. (1998) Eosinophilic granuloma of the jaws. British Journal Of Oral Maxillofacial Surgery;36:380-83

. Hartman KS. Histiocytosis (1980) A review of 114 cases with oral involvement. Oral Surg Oral Med Oral Pathol ;49:38-54.

. Zuendel MT, Bowers DF, Kramer BN. (1984) Recurrent histiocytosis X with mandibular lesions. Oral Surg Oral Med Oral Pathol ;58:420-3.

. Favara BE, McCarthy RC, Mierau GW. (1983) Histiocytosis X. Human Pathol ;14:663-76.

DOI: http://dx.doi.org/10.24294/as.v1i2.637


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License

This site is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.