Applied Chemical Engineering (Transferred)

Sodium dimethyl dithiocarbamate (SDDC) is a universal heavy metal precipitant/chelating agent, which is widely used in the treatment of heavy metals in industrial wastewater and fly ash from waste incineration. It can be utilized as a heavy metal precipitant, fungicide, agricultural insecticide, rubber vulcanization accelerator, styrene-butadiene rubber polymerization terminator, polymerization inhibitor, mineral processing reagent, etc. This review article focuses on the research of the production and application of SDDC in heavy metal chelation. The following three benefits of using SDDC as a heavy metal chelating agent are: (1) It can chelate with various heavy metal ions at room temperature to generate insoluble chelate salts and precipitates, which can be easily removed; (2) SDDC can perform chelation reaction with varies heavy metal ions at the same time; (3) As a heavy metal chelating agent, SDDC is simple to use and low costs, which is significantly better than other heavy metal chelating agents and precipitants. This review paper presents novel ideas for the performance enhancement based on SDDC in removing heavy metals and is a prospect for the research, development, production, and applications of SDDC.

1. Ministry of Ecology and Environment, People’s Republic of China. The ministry of environmental protection and

2. the ministry of land and resources issued a communique on a national survey (Chinese). Available online:

3. https://www.mee.gov.cn/gkml/sthjbgw/qt/201404/t20140417_270670.htm (accessed on 10 August 2023).

4. Ministry of Environmental Protection. The “Twelfth Five-Year” plan for comprehensive prevention and control of

5. heavy metal pollution (Chinese). Available online:

6. https://www.mee.gov.cn/ywdt/hjnews/201409/W020140903603840681475.pdf (accessed on 10 August 2023).

7. Ministry of Ecology and Environment, People’s Republic of China. Opinions on further strengthening prevention

8. and control of heavy metal pollution (Chinese). Available online:

9. https://www.mee.gov.cn/xxgk2018/xxgk/xxgk03/202203/t20220315_971552.html (accessed on 10 August 2023).

10. Fu F, Wang Q. Removal of heavy metal ions from wastewaters: A review. Journal of Environmental Management

11. ; 92(3): 407–418. doi: 10.1016/j.jenvman.2010.11.011

12. Barakat MA. New trends in removing heavy metals from industrial wastewater. Arabian Journal of Chemistry

13. ; 4(4): 361–377. doi: 10.1016/j.arabjc.2010.07.019

14. Wilson AM, Bailey PJ, Tasker PA, et al. Solvent extraction: The coordination chemistry behind extractive

15. metallurgy. Chemical Society Reviews 2014; 43(1): 123–134. doi: 10.1039/C3CS60275C

16. Sole KC. Solvent Extraction in the Hydrometallurgical Processing and Purification of Metals: Process Design and

17. Selected Applications, 1st ed. CRC Press; 2008. pp. 159–218.

18. Kislik VS. Solvent Extraction: Classical and Novel Approaches. Elsevier; 2012.

19. Chai WS, Cheun JY, Kumar PS, et al. A review on conventional and novel materials towards heavy metal

20. adsorption in wastewater treatment application. Journal of Cleaner Production 2021; 296: 126589. doi:

21. 1016/j.jclepro.2021.126589

22. Burakov AE, Galunin EV, Burakova IV, et al. Adsorption of heavy metals on conventional and nanostructured

23. materials for wastewater treatment purposes: A review. Ecotoxicology and Environmental Safety 2018; 148: 702–

24. doi: 10.1016/j.ecoenv.2017.11.034

25. Larasati A, Fowler GD, Graham NJD. Chemical regeneration of granular activated carbon: Preliminary evaluation

26. of alternative regenerant solutions. Environmental Science: Water Research & Technology 2020; 6(8): 2043–2056.

27. doi: 10.1039/D0EW00328J

28. Li YZ. A production device and method for sodium dimethyldithiocarbamate (Chinese). CN106397289B, 23

29. February 2018.

30. Da̧ browski A, Hubicki Z, Podkościelny P, Robens E. Selective removal of the heavy metal ions from waters and

31. industrial wastewaters by ion-exchange method. Chemosphere 2004; 56(2): 91–106. doi:

32. 1016/j.chemosphere.2004.03.006

33. Esmaeili H, Foroutan R. Investigation into ion exchange and adsorption methods for removing heavy metals from

34. aqueous solutions. International Journal of Biology, Pharmacy and Allied Sciences 2015; 4(12): 620–629.

35. Fu F, Xie L, Tang B, et al. Application of a novel strategy—Advanced Fenton-chemical precipitation to the

36. treatment of strong stability chelated heavy metal containing wastewater. Chemical Engineering Journal 2012;

37. –190: 283–287. doi: 10.1016/j.cej.2012.02.073

38. Fu F, Chen R, Xiong Y. Application of a novel strategy—Coordination polymerization precipitation to the

39. treatment of Cu2+

40. -containing wastewaters. Separation and Purification Technology 2006; 52(2): 388–393. doi:

41. 1016/j.seppur.2006.05.017

42. Ying X, Fang Z. Experimental research on heavy metal wastewater treatment with dipropyl dithiophosphate.

43. Journal of Hazardous Materials 2006; 137(3): 1636–1642. doi: 10.1016/j.jhazmat.2006.04.055

44. Sodium dimethyldithiocarbamate. Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Sodiumdimethyldithiocarbamate (accessed on 26 August 2023).

45. Kim TK, Kim T, Choe WS, et al. Removal of heavy metals in electroplating wastewater by powdered activated

46. carbon (PAC) and sodium diethyldithiocarbamate-modified PAC. Environmental Engineering Research 2018;

47. (3): 301–308. doi: 10.4491/eer.2017.208

48. Chen JP, Wu S, Chong KH. Surface modification of a granular activated carbon by citric acid for enhancement of

49. copper adsorption. Carbon 2003; 41(10): 1979–1986. doi: 10.1016/S0008-6223(03)00197-0

50. Owlad M, Aroua MK, Daud WMAW. Hexavalent chromium adsorption on impregnated palm shell activated

51. carbon with polyethyleneimine. Bioresource Technology 2010; 101(14): 5098–5103. doi:

52. 1016/j.biortech.2010.01.135.

53. Available online: http://www.lanquanhuanbao.com/m/view.php?aid=81 (accessed on 10 August 2023).

54. Wang Y, Zhang H, Wu X, et al. Ecotoxicity assessment of sodium dimethyldithiocarbamate and its micro-sized

55. metal chelates in Caenorhabditis elegans. Science of The Total Environment 2020; 720: 137666. doi:

56. 1016/j.scitotenv.2020.137666

57. Abdollahi M, Khaksar MR. Sodium Dimethyldithiocarbamate, 3rd ed. Academic Press; 2014.

58. Lei G, Gao PF, Liu H, Huang CZ. Real-time scattered light dark-field microscopic imaging of the dynamic

59. degradation process of sodium dimethyldithiocarbamate. Nanoscale 2015; 7(48): 20709–20716. doi:

60. 1039/C5NR05838D

61. Mack JM, Moura TM, Lanznaster D, et al. Intranasal administration of sodium dimethyldithiocarbamate induces

62. motor deficits and dopaminergic dysfunction in mice. Neurotoxicology 2018; 66: 107–120. doi:

63. 1016/j.neuro.2018.03.011

64. Tianjin Pesticide Test Factory. The optimization of “preferential method” in the production of sodium

65. dimethyldithiocarbamate intermediates (Chinese). Tianjin Chemical Industry 1973; 6: 35–36.

66. Sodium dimethyldithiocarbamate, 40% in water. Available online: https://www.gelest.com/wpcontent/uploads/AKS736_SODIUM-DIMETHYLDITHIOCARBAMATE-40-in-water_GHS-US_English-US.pdf

67. (accessed on 10 August 2023).

68. Zhang F, Yuan Y. Safety measures for storage and use of carbon disulfide in the production of sodium

69. dimethyldithiocarbamate (Chinese). Liaoning Chemical Industry 2021; 50(11): 701–703.

70. Zhang Q. Research and Development of Automation Control System for SDDC Production [Master’s thesis].

71. University of Jinan; 2017.

72. Tian X. Analysis of industrial synthesis and application technology of sodium dimethyldithiocarbamate (Chinese).

73. Shandong Chemical Industry 2018; 47(20): 63–64.

74. Li YZ. A Production Device for SDDC and Its Production Method (Chinese). CN106397289B, 23 February 2018.

75. Guo XR, Li SY, Zhuang Q, et al. A Production Device for Liquid SDDC and Its Production Method (Chinese).

76. CN103214405A, 20 January 2016.

77. Institute of Solid Waste Pollution Control, Chinese Academy of Environmental Sciences. Solid Waste-Extraction

78. Procedure for Leaching Toxicity-Acetic Acid Buffer Solution Method. HJ/T 300-2007 (Chinese). State

79. Environmental Protection Administration; 2007.

80. China Environmental Publishing Group. Standard for Pollution Control on the Landfill Site of Municipal Solid

81. Waste. GB16889-2008 (Chinese). China Environmental Publishing Group; 2008.

82. He H, Zhu T, Liu Z, et al. Treatment of cadmium-containing wastewater in zinc smelting using sodium

83. dimethyldithiocarbamate (Chinese). Environmental Protection of Chemical Industry 2015; 35(03): 293–296.

84. Ma X. Study on the effect of sodium dimethyldithiocarbamate on purification of manganese (II) sulfate solution

85. (Chinese). Xinjiang Nonferrous Metals 2020; 43(05): 90–96.

86. Lao Q, Su Q, Liu G, et al. Spatial distribution of and historical changes in heavy metals in the surface seawater and

87. sediments of the Beibu Gulf, China. Marine Pollution Bulletin 2019; 146: 427–434. doi:

88. 1016/j.marpolbul.2019.06.080

89. Islam MS, Ahmed MK, Raknuzzaman M, et al. Heavy metal pollution in surface water and sediment: A

90. preliminary assessment of an urban river in a developing country. Ecological Indicators 2015; 48: 282–291. doi:

91. 1016/j.ecolind.2014.08.016

92. Yang W, Huang D, Chen J, et al. Pollution assessment and temporal-spatial distribution of heavy metals in

93. seawater of Daya bay during 2009–2018 (Chinese). Journal of South China Normal University (Natural Science

94. Edition) 2020; 52(05): 65–75.

95. Lai HW, Guo CW, Chen K. Combined process for treatment of HEDP copper electroplating wastewater (Chinese).

96. Electroplating & Finishing 2021; 40(5): 400–403.

97. Liu BZ, Li MR, Li XY. Discussion on the purification of zinc sulfate solution by sodium diethyldithiocarbamate

98. (Chinese). Yunnan Chemical Industry 2021; 48(06): 65–67.

99. Sunderman FW. Use of sodium diethyldithiocarbamate in the treatment of nickel carbonyl poisoning. Annals of

100. Clinical and Laboratory Science 1990; 20(1): 12–21.

101. Tarique M. Coordination aspects of dimethyldithiocarbamate ligand towards the first series transition metal ions.

102. Chemical Science Transactions 2012; 1(2): 257–260. doi: 10.7598/cst2012.150

103. Ma Q, Chi CH, Huang XH, et al. Determination of sodium dimethyldithiocarbamate in water by pre-column

104. derivatization-high performance liquid chromatography (Chinese). Guangzhou Chemistry 2019; 44(05): 47–51.

105. Zhang HL, Li XP, Qi JY, et al. Primary Research on Health Risk Assessment of Heavy Metals in the Surrounding

106. Soil and Air of a Municipal Solid Waste Incinerator (MSWI), South China (Chinese). Journal of AgroEnvironment Science 2013; 32(8): 1670–1676.

107. Zhang Z, Chen WH. Health hazards of dioxin-like compounds (Chinese). Environmental and Occupational

108. Medicine 2019; 36(11): 1007–1009.

109. Huang JQ. Study on the Pollution Characteristics and Risk Assessment of PCDD/Fs and Heavy Metals in the

110. Environment around a Waste Incineration Plant in the South (Chinese) [Master’s thesis]. Zhongkai University of

111. Agriculture and Engineering; 2017.

112. Xu MX. Study on the Environmental Impact of Dioxin Emissions from Urban Municipal Solid Waste Incinerators

113. [PhD thesis]. Zhejiang University; 2009.

114. Rovira J, Mari M, Nadal M, et al. Environmental monitoring of metals, PCDD/Fs and PCBs as a complementary

115. tool of biological surveillance to assess human health risks. Chemosphere 2010; 80(10): 1183–1189. doi:

116. 1016/j.chemosphere.2010.06.016

117. Wang YS, Zhong CQ, Liu CJ, et al. Study on the levels of dioxins in the environmental air, fly ash and soil of

118. waste incineration plants and risk assessment (Chinese). Journal of South China Normal University (Natural

119. Science Edition) 2020; 52(05): 49–56.

120. Wang YS, Liu CJ, Chen XY, et al. Risk assessment of heavy metal pollution in the soil surrounding waste

121. incineration plants (Chinese). Journal of South China Normal University (Natural Science Edition) 2020; 52(05):

122. –64.

123. Ministry of Ecology and Environment. Regulations on the application of automatic monitoring data in domestic

124. waste incineration power plants (Chinese). Available online:

125. https://www.mee.gov.cn/xxgk2018/xxgk/xxgk02/201912/t20191202_744979.html (accessed on 10 August 2023).

126. Bie R, Chen P, Song X, Ji X. Characteristics of municipal solid waste incineration fly ash with cement

127. solidification treatment. Journal of the Energy Institute 2016; 89(4): 704–712. doi: 10.1016/j.joei.2015.04.006

128. Lv CX, Tong LZ, Hu B, et al. Study on the extraction method of heavy metal chelates in fly ash after stabilization

129. treatment (Chinese). In: Proceedings of the 2019 Annual Scientific and Technical Meeting of the China

130. Environmental Science Society; 23 August 2019; Xi’an, Shaanxi Province, China. pp. 579–584.

131. Xiao J, Chen DX, Yang JW, et al. Separation tests of the lead-zinc-sulfur mixed concentrate in Fankou lead and

132. zinc mine (Chinese). Nonferrous Metals Science and Engineering 2015; 6(02): 104–110.

133. Jiao F. Fundamental Research on the Efficient Separation of Complex Copper-Zinc Sulfide Ore by Floatation

134. (Chinese) [PhD thesis]. Central South University; 2013.

135. Yilmaz E, Yazici EY, Ahlatci F, et al. Precipitation of copper from cyanide leach solutions using sodium

136. dimethyldithiocarbamate (SDDC). Hydrometallurgy 2021; 202: 105610. doi: 10.1016/j.hydromet.2021.105610

137. Chanturiya VA, Matveeva TN, Lantsova LB. Investigation into products of dimethyldithiocarbamate and xanthate

138. sorption on sulfide minerals of copper-nickel ores. Journal of Mining Science Volume 2003; 39: 281–286. doi:

139. 1023/B:JOMI.0000013787.16229.96

140. Arslana G, Yilmaz A, Tor A, Ersoz M. Preparation of polymer inclusion membrane with sodium

141. diethyldithiocarbamate as a carrier reagent for selective transport of zinc ions. Desalination and Water Treatment

142. ; 75: 348–356. doi: 10.5004/dwt.2017.20485

143. Wang FH, Shi WY, Wang ZL. Quantum chemistry study on six heavy metal ions complexes with

144. dimethyldithiocarbamate (Chinese). Computers and Applied Chemistry 2012; 29(6): 647–650.

145. Karimov A, Orujova A, Taslimi P, et al. Novel functionally substituted esters based on sodium

146. diethyldithiocarbamate derivatives: Synthesis, characterization, biological activity and molecular docking studies.

147. Bioorganic Chemistry 2020; 99: 103762. doi: 10.1016/j.bioorg.2020.103762