PEG as versatile mediating agent for sensing heavy metal ions: A mini review

Rajib Biswas

Article ID: 2364
Vol 6, Issue 3, 2023

VIEWS - 815 (Abstract) 116 (PDF)


The increasing presence of heavy metal ions in aquatic environments has become a subject of escalating concern in contemporary times. Numerous human-induced activities have contributed to an elevated presence of heavy metal ions in aquatic environments, surpassing the threshold levels established by the World Health Organisation (WHO). Recently, there has been a significant increase in the utilisation of polyethylene glycol (PEG) due to its exceptional characteristics in addressing the pressing issue of aquatic pollution resulting from the presence of heavy metal ions. This mini review evaluates the detection activities in which PEG plays a significant role. The detection strategy utilising PEG composites is thoroughly described, beginning with an examination of the inherent properties of PEG. Furthermore, it concludes with suggestions for future research in this area.


functionalization; PEG; heavy metal; detection; selectivity

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1. Mahapatro A, Singh DK. Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines. Journal of Nanobiotechnology 2011; 9: 55. doi: 10.1186/1477-3155-9-55

2. Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and Surfaces B: Biointerfaces 2010; 75(1): 1–18. doi: 10.1016/j.colsurfb.2009.09.001

3. Sinha VR, Singla AK, Wadhawan S, et al. Chitosan microspheres as a potential carrier for drugs. International Journal of Pharmaceutics 2004; 274(1–2): 1–33. doi: 10.1016/j.ijpharm.2003.12.026

4. Biswas R, Saha D, Biswas S. Novel ethanol sensing via clad modified fiber with SnO2: CuO with wireless adaptability. Applied Nanoscience 2021; 11: 2617–2623. doi: 10.1007/s13204-021-02146-2

5. Barman C, Neog A, Biswas S, Biswas R. A preliminary investigation towards detecting heavy metal ions with a cost-effective scheme. Letters in Applied NanoBioScience 2022; 11(3): 3822–3825. doi: 10.33263/LIANBS113.38223825

6. Gan Q, Wang T. Chitosan nanoparticle as protein delivery carrier—Systematic examination of fabrication conditions for efficient loading and release. Colloids and Surfaces B: Biointerfaces 2007; 59(1): 24–34. doi: 10.1016/j.colsurfb.2007.04.009

7. Verma R, Gupta BD. Detection of heavy metal ions in contaminated water by surface plasmon resonance based optical fibre sensor using conducting polymer and chitosan. Food Chemistry 2015; 166: 568–575. doi: 10.1016/j.foodchem.2014.06.045

8. Ibrahim SA, Ridzwan AH, Mansoor A, Dambul KD. Tapered optical fibre coated with chitosan for lead (II) ion sensing. Electronics Letters 2016; 52(12): 1049–1050. doi: 10.1049/el.2016.0762

9. Raghunandhan R, Chen LH, Long HY, et al. Chitosan/PAA based fiber-optic interferometric sensor for heavy metal ions detection. Sensors and Actuators B: Chemical 2016; 233: 31–38

10. Pillai CKS, Paul W, Sharma CP. Chitin and chitosan polymers: Chemistry, solubility and fiber formation. Progress in Polymer Science 2009; 34(7): 641–678. doi: 10.1016/j.progpolymsci.2009.04.001

11. Gamage A, Shahidi F. Use of chitosan for the removal of metal ion contaminants and proteins from water. Food Chemistry 2007; 104(3): 989–996.

12. Ngah WSW, Teong LC and Hanafiah MAKM. Adsorption of dyes and heavy metal ions by chitosan composites: A review. Carbohydrate Polymers 2011; 83(4): 1446–1546. doi: 10.1016/j.carbpol.2010.11.004

13. BOC Sciences. Introduction of polyethylene glycol (PEG). Available online:,or%20usually%20methanol%20or%20water%20as%20an%20initiator (accessed on 7 September 2023).

14. D’souza AA, Shegokar R. Polyethylene glycol (PEG): A versatile polymer for pharmaceutical applications. Expert Opinion on Drug Delivery 2016; 13(9): 1257–1275. doi: 10.1080/17425247.2016.1182485

15. Hu L, Zhang L, Zhou Y, et al. Chitosan-stabilized gold nano composite modified glassy carbon electrode for electrochemical sensing trace Hg2+ in practice. Journal of the Electrochemical Society 2018; 165: B900–B905. doi: 10.1149/2.1101816jes

16. Wu KH, Lo HM, Wang JC, et al. Electrochemical detection of heavy metal pollutant using crosslinked chitosan/carbon nanotubes thin film electrodes. Material Express 2017; 7(1): 15–24. doi: 10.1166/mex.2017.1351

17. Khatri A, Punjabi N, Ghosh D, et al. Detection and differentiation of α-Synuclein monomer and fibril by chitosan film coated nanogold array on optical sensor platform. Sensors and Actuators B: Chemical 2018; 255: 692–700. doi: 10.1016/j.snb.2017.08.051

18. Wexler P. Encyclopedia of Toxicology, 3rd edition. Academic Press; 2014.

19. Kikuchi A. Comprehensive Biomaterials II. Elsevier; 2017.

20. Baruah BS, Daimari NK, Biswas R. Mangiferaindica leaf extract mediated gold nanoparticles: A novel platform for sensing of As (III). IEEE Sensors Letter 2019; 3(3): 1–3. doi: 10.1109/LSENS.2019.2894419

21. Biswas R. Heavy metal ion pollution in aqueous solution: An environmental hazard. International Journal of Environmental Sciences and Natural Resources 2019; 16(2). doi: 10.19080/IJESNR.2019.16.555933

22. Joshi BP, Park JY, Lee KH. Recyclable sensitive fluorimetric detection of specific metal ions using a functionalized PEG-PS resin with a fluorescent peptide sensor. Sensors and Actuators B: Chemical 2014; 191: 122–129. doi: 10.1016/j.snb.2013.09.075

23. Jia H, Li Z, Wang X, Zheng Z. Facile functionalization of a tetrahedron-like PEG macromonomer-based fluorescent hydrogel with high strength and its heavy metal ion detection. Journal of Materials Chemistry A 2015; 3: 1158–1163. doi: 10.1039/C4TA05736H

24. Zheng X, Ren S, Wang L, et al. Controllable functionalization of carbon dots as fluorescent sensors for independent Cr(Ⅵ), Fe(Ⅲ) and Cu(Ⅱ) ions detection. Journal of Photochemistry and Photobiology A: Chemistry 2021; 417: 113359. doi: 10.1016/j.jphotochem.2021.113359

25. Bai L, Li G, Li L, et al. Schiff base functionalized PEG as a high efficient fluorescent chemosensor for Al3+ detection in 100% aqueous solution. Reactive and Functional Polymers 2019; 139: 1–8. doi: 10.1016/j.reactfunctpolym.2019.03.007

26. Baruah BS, Biswas R. Selective detection of arsenic (III) based on colorimetric approach in aqueous medium using functionalized gold nanoparticles unit. Material Research Express 2018; 5(1): 015059. doi: 10.1088/2053-1591/aaa661

27. Boruah BS, Daimari NK, Biswas R. Functionalized silver nanoparticles as an effective medium towards trace determination of arsenic (III) in aqueous solution. Results in Physics 2019; 12: 2061–2065. doi: 10.1016/j.rinp.2019.02.044

28. Bui MPN, Brockgreitens J, Ahmed S, Abbas A. Dual detection of nitrate and mercury in water using disposable electrochemical sensors. Biosensors and Bioelectronics 2016; 85: 280–286. doi: 10.1016/j.bios.2016.05.017

29. Lou Y, Ji J, Qin A, et al. Cane molasses graphene quantum dots passivated by PEG functionalization for detection of metal ions. ACS Omega 2020; 5(12): 6763–6772. doi: 10.1021/acsomega.0c00098

30. Priyadarshni N, Nath P, Nagahanumaiah, Chanda N. DMSA-functionalized gold nanorod on paper for colorimetric detection and estimation of arsenic (III and V) contamination in groundwater. ACS Sustainable Chemistry & Engineering 2018; 6(5): 6264–6272. doi: 10.1021/acssuschemeng.8b00068

31. Lou Y, Sun W, Jiang L, et al. Double-enhanced fluorescence of graphene quantum dots from cane molasses via metal and PEG modification for detecting metal ions and pigments. Optical Materials 2022; 133(2): 113037. doi: 10.1016/j.optmat.2022.113037

32. Welch NG, Scoble JA, Muir BW, Pigram PJ. Orientation and characterization of immobilized antibodies for improved immunoassays (Review). Biointerphases 2017; 12(2): 02D301. doi: 10.1116/1.4978435

33. Ahmed HT, Jalal VJ, Tahir DA, et al. Effect of PEG as a plasticizer on the electrical and optical properties of polymer blend electrolyte MC-CH-LiBF4 based films. Results in Physics 2019; 15: 102735. doi: 10.1016/j.rinp.2019.102735



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