Medical honey and the role in pediatric emergency wound management

Stefan Bittmann, Anne Weissenstein, Gloria Villalon, Elisabeth Luchter

Article ID: 780
Vol 5, Issue 1, 2022

VIEWS - 2122 (Abstract) 579 (PDF)

Abstract


The use of complementary medical treatment in wound management has continued to grow throughout the world. There is a large body of evidence to support the use of honey as a wound dressing for a wide range of types of wounds. Clear guidelines for the use of honey in pediatric wound care do not exist. We present an update of present knowledge using honey as a form of complementary medicine in pediatric wound management.

Keywords


Honey; pediatric; child; wound; infection

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References


1. Tan ST, Wilkins AL, Molan PC, et al. A chemical approach to the determination of floral sources of New Zealand honeys.Journal of Agricultural Research 1989; 28(4): 212-22.

2. Allen KL, Molan PC, Reid GM. A survey of the antibacterial activity of some NewZealand honeys. Journal of Pharmacy and Pharmacology 1991; 43: 817-22.

3. Willix DJ, Molan PC, Harfoot CG. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey. Journal of Applied Bacteriology 1992; 73: 388-94.

4. White JW, Reithof ML, Subers MH, et al. Composition of American honeys. US Dept Agr Tech Bull 1962; 1261: 1-124.

5. Bauer L, Kohlich A, Hirschweir R, et al. Food allergy to honey: pollen or bee products? Characteriziation of allergenic proteins in honey by means of immunoblotting. J Allergy Clion Immunol 1996; 97 (1): 65-73.

6. Postmes TJ, Bosch MMC, et al. Speeding up the healing of burns with honey. In: Mizrahi A, Lensky Y 8eds), Bee Products: Properties, applications and apitherapy. New York, Plenum Press1997; 27-37.

7. Molan PC. The antibacterial properties of honey. Chem in NZ 1995;10-14.

8. Zumla A, Lulat A. Honey-aremedy rediscovered. J Royal Soc Medicine 1989; 82: 384-5.

9. Beck BF, Smedley D. Honey and your health. 2nd edn., New York: Mc Bride, 1944

10. Molan PC. Why honey is effective as a medicine?-the scientific explanation of the effects. In Honey and healing (Munn P, Jones R eds). International Bee Research Association 2001.

11. Moore OA, Smith A, Campbell F, et al. A systematic review of the use of honey as a wound dressing. BMC Complementary and Alternative Medicine 2001; 1(1) 2.

12. Fox C. Honey as a dressing for chronic wounds in adults. British Journal of Community Nursing 2002; 10: 530-534.

13. Gethin G. Is there enough clinical evidence to use honey to manage wounds? Journal of Wound Care 2004; 7: 275-278.

14. Cooper RA, Molan PC, Krishnamoorty L, et al. Manuka honey used to heal a recalcitrant surgical wound. Eur J Clin Microbiol Infect Dis 2001; 20 (10): 758-759.

15. Dixon B. Bacteria can`t resist honey. Lancet Infect Dis 2003; 3 (2): 116.

16. Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs 2002; 29 (6): 295-300.

17. Molan PC. Potential of honey in the treatment of wound and burns. Am J Clin Dermatol 2001; 2 (1): 13-9.

18. Sofka K, Wiszniewsky G, Blaser G, et al. Antibakterieller Honig (Medihoney TM) zur Wundpflege-Wundantisepsis bei pädiatrischen Patienten in der Hämatologie-Onkologie? Krh Hyg Inf verh 2004; 26 (5): 183-7.

19. Simon A, Sofka K, Wizniewsky G, et al;. Wound care with antibacterial honey (Medihoney) in pediatric hematology-oncology. Support Care Cancer 2006; 14: 91-97.

20. Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocon for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005; 16: 1-7.

21. White JW, Reithof ML, Subers MH, et al. Composition of american honeys. US Dept Agr Tech Bull 1962; 1261: 1-124.

22. White JW, Hoban N. Composition of honey, identification of disaccharides. Arch Biochem Biophys 1959; 80: 386-392.

23. Siddiqui IR, Furgala B. Isolation and characterization of oligosaccharides (Trisaccharides) from honey. J Apc Res 1968; 7: 51-59.

24. Wood B, Rademaker M, Molan P. Manuka honey, a low cost leg ulcer dressing. New Zealand Medical Journal 1997; 110(1040): 107.

25. Lawrence JC. Honey and wound bacteria. Editorial. Journal of Wound Care 1999; 8 (4):155.

26. Thomas S. Wound management and dressings. The Pharmaceutical Press.

27. Ambrose U, Middleton K, Seal D. In vitro studies of water activity and bacterial growth inhibition of sucrose-polyethylene glycol 400-hydrogen peroxide pastes used to treat wounds. Antimicrobial Agents Chemotherapy 1991; 35(9): 1799-1803.

28. Booth S. Are honey and sugar paste alternatives to topical antiseptics? Journal of Wound Care 2004; 13(1): 31-3.

29. Topham J. Why do some cavity wounds treated with honey or sugar paste heal without scarring? Journal of Wound Care 2001; 11(2): 53-55.

30. Mirsirlioglu A, Eroglu S, Karacaoglan N, et al. Use of honey as an adjunct in the healing of split thickness donor site. Dermatologic Surgery 2003; 29(2): 168- 172.

31. Molan PC. Clinical usage of honey as a wound dressing: an update. J Wound Care 2004; 13(9): 353-6.

32. Marshall C, Queen J, Manjooran J. Honey vs povidone iodine following toenail surgery. Wounds 2005; 1(1): 10-18.

33. Bangroo AK, Khatri R, Chauban S. Honey dressing in pediatric burns. J Indian Assoc Pediatr Surg 2005; 10(3): 172-5.

34. Dustman JH. Antibacterial effect of honey. Apiacta 1979; 14: 7-11.

35. Akinci S, Arslan U, Karakurt K. Cengel A. An unusual presentation of mad honey poisoning: Acute myocardial infarction. Int J Cardiol Sep 20 (Epub ahead of print)

36. Mphande AN, Killowe C, Phalira S, et al. Effects of honey and sugar dressings on wound healing. J Wound Care 2007; 16(7): 317-9.

37. Ozlugedik S, Genc S, Unal A, et al. Can postoperative pains following tonsillectomy be relieved by honey? A prospective, randomized, placebo controlled preliminary study. Int J Pediatr Otorhinolaryngol 2006; 70(11): 1929-34.

38. Blaser G, Santos K, Bode U, et al. Effect of medical honey on wounds colonised or infected with MRSA. J Wound Care 2007; 16(8): 325-8.

39. Holzgreve H. Honey is better than aciclovir in herpes. MMW Fortschr Med 2005; 147(3): 18.

40. Al-Waili N. Topical honey application vs. Acyclovir for the treatment of recurrent herpes simplex lesions. Med Sci Monit 2004; 10(8): MT94-98.

41. Al-Waili N. Identification of nitric oxide metabolites in various honeys: Effects of intravenous honey on plasma and urinary nitric oxide metabolites concentrations. J Med Food 2003; 6: 359-64.

42. Torre D, Pugliese A, Speranza F. Role of nitric oxide in HIV-1-infection: friend or foe? Lancet Infect Dis 2002; 2: 273-80.

43. Al-Waili N. Effects of honey ingestion on nitric oxide in saliva. FASEB J 2003; 17: A767

44. Al-Waili N, Boni N. Effect of honey on blood and urinary nitric oxide in normal individuals. FASEB J 2003; 17: A660

45. Jull A, Walker N, Parag V, et al. on behalf of the honey as Adjuvant Leg Ulcer Therapy trial collaborators. Randomized clinical trial of honey-impregnated dressings for venous leg ulcers. Br J Surg 2007; 95(2): 175-182.

46. Vardi A, Barzilay Z, Linder N, et al. Local application of honey for treatment of neonatal postoperative wound infection. Acta Paediatr 1998; 87(4): 429-32.

47. Dilber E, Kalyoncu M, Yaris N, et al. A case of Mad Honey Poisoning presenting with convulsion: Intoxication instead of alternative therapy. Turk J Med Sci 2002; 32: 361-2.

48. Natarajan S, Williamson D, Grey J, et al. Healing of an MRSA-

49. colonised, hydroxyurea-induced leg ulcer with honey. J Dermatol Treat 2001; 12(1): 33-6.

50. Narahishi T, Seyama I. Mechanism of nerve membrane depolarization caused by grayanotoxin I. J Physiol 1974; 242: 471-478.

51. Seyama I, Narahishi T. Modulation of sodium channel of squid nerve membranes by grayanotoxin I. J Pharmacol Exp Ther 1981; 219: 614-24.

52. Lusby PE, Coombes AL, Wilkinson JM. Bactericidal activity of different honeys against pathogenic bacteria. Arch Med Res 2005; 36:464-7.

53. Cooper RA, Molan PC, Harding KG. The sensitivity to honey of gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol 2002; 93: 857-63.

54. Cooper RA, Molan PC, Harding KG. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med 1999; 92: 283-5.

55. Molan PC: The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 2006; 5:40-2.

56. Bang LM, Buntting C, Molan P. The effect of dilution on the rate of hydrogen peroxide production in honey and implications for wound healing. J Altern Complement Med 2003; 9: 267-73.

57. Tonks AJ, Cooper RA, Jones KP, et al. Honey stimulates inflammatory cytokine production from monocytes. Cytokine 2003; 21: 242-7.

58. Tonks A, Cooper RA, Price AJ, et al.. Stimulation of TNF-alpha release in monocytes by honey. Cytokine 2001; 14: 240-2.

59. Abubarfeil N, Al-Oran R, Abo-Shehada M. The effect of bee honey on proliferative activity of human B- and T-lymphocytes and the activity of phagocytes. Food Agri Immunol 1999; 11: 169-77.

60. Tonks AJ, Dudley E, Porter NG, et al.. A 5,8-kDa component of manuka honey stimulates immune cells via TLR4. J Leukoc Biol 2007; 82: 1147-55.

61. Molan PC. The antibacterial activity of honey. The nature of the antibacterial activity. Bee World 1992; 73: 5-28.




DOI: https://doi.org/10.24294/jpedd.v2i2.780

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