Detection of mammary adenocarcinoma and metastasis with 99mTc-Thymine in a cat

Paulo S. Castelo Branco 1, Gabriel Gutfilen-Schlesinger 2, Priscila Sena 3, Guile Gutfilen-Schlesinger 1, Sergio A. L. Souza 1, Bianca Gutfilen 1

Abstract


Mammary adenocarcinomas with metastasis are more common in dogs than in cats. Its incidence is 1 in every 4,000 cats. Usually, veterinary routine laboratory exams are nonspecific for these neoplasms and tumoral markers are not widely used in the practice. The clinical evaluation and image assessment leads the way to the proper treatment, especially when surgical intervention is a possibility. Although an invasive procedure, biopsy and histopathological findings are the gold standards which define the clinical approach. Procedures: This study describes the clinical signs, histopathological aspects, radiological and scintigraphic findings of a cat with mammary adenocarcinoma and metastasis evaluated one hour after intravenous administration of 99mTc-Thymine. Our focus is not to discuss the pathological aspects of the disease but the nuclear medicine role in metastasis detection. Metastasis when lesser than 4mm, could be unnoticed by radiological exams whereas scintigraphy may detect it. Results: Here, we successfully detected unsuspected metastasis in lungs, liver and right kidney. Early diagnosis is the key for a better rate of survival due to the given treatment and, prognostic. Conclusions: We strongly recommend the use of 99mTc-Thymine as a complementary tool for breast cancer diagnosis in veterinary care.


Keywords


mammary adenocarcinoma; 99mTc-Thymine; Diagnosis; Scintigraphy; Veterinary care

Full Text:

PDF

References


Furian M, Sandei CFCS, Rocha EJN,et al.Estudo retrospectivo dos tumores mamários em caninos e felinos atendidos no hospital veterinário da famed entre 2003 a 2007. Rev Cient Eletrônica Med Vet 2007; 4(8):1-4.

Daleck CR, Franceschini PH, Alessi AC,et al.. Aspectos clínico e cirúrgico do tumor mamário canino. Cienc Rural 1998;28:95-100.

Johnston SD. Reproductive systems. In: Slatter, D. Textbook of Small Animal Surgery. 2nd ed. Philadelphia: Saunders 1993;. 2177-2199.

Morrisson WB. Canine and feline mammary tumors. In: Morrisson W.B. (Ed). Cancer in dogs and cats – medical and surgical management. Baltimore: Williams & Wilkins 1998. 591-598.

Carothers M . Neoplasia respiratória. In: Bichard S. J., Sherding R. G. Clínica de pequenos animais. São Paulo: Roca 1998, 663-665.

Morris J. Mammary tumours in the cat: Size matters, so early intervention save lives. JFMS 2013;15: 391-400

Giméney F. Early detection; aggressive therapy: Optimizing the management of feline mammary masses. JFMS 2010;12: 214-224

Mattoon JS, Bryan JN. The future of imaging in veterinary oncology: Learning from human medicine. Vet J 2013;197(3):541-52.

Withrow SJ Tumor of the respiratory system. In: Withrow S. J., Macewen E. G. Small animal clinical oncology. 3rd. ed. Philadelphia: Saunders.2001; 361-369.

Freeman LM. Freeman and Johnson’s Clinical Radionuclide Imaging. Grune and Stratton Inc., Orlando, Florida.1986; 1528.

Early P, Sodee B (1995). Principles and Practice of Nuclear Medicine. Mosby Inc., St Louis, Missouri.

Gutfilen B, Rodrigues E, Soraggi R, et al. Preliminary observation of 99mTc-thymine imaging in breast neoplasms. Nucl Med Commun 2001;22(10):1133-7.

Gutfilen B, Fonseca LM. Comparison of Tc-99m THY and Tc-99m MIBI scans for diagnosis of breast lesions. J Exp Clin Cancer Res 2001; 20:385-391.

Ribeiro MP, Souza SA, Lopes FP, et al. 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer. Clinics (Sao Paulo) 2013;68(3):283-9.

Tanigawa N, Morimoto H, Dohmae N, et al . In vitro growth ability and chemosensitivity of gastric and colorectal cancer cells assessed with the human tumor clonogenic assay and thymidine incorporation assay. Eur J Cancer 1992; 28:31-34.

León E, Rey A, Savio E, et al. 99mTc-ADP: agente potencial para la deteccion in vivo de tumores. Rev Esp Med Nuclear XII 1993;,266.

Pereira CT, Luiz Navarro Marques F, Williams J, et al. 99mTc-labeled dextran for mammary lymphoscintigraphy in dogs. Vet Radiol Ultrasound 2008. 49(5):487-91.

Hayden DW, Nielsen SW . Feline Mammary tumours. J small anim practice 1971; 12: 687-98

Hanh KA, Adams WH. Feline mammary neoplasia: Biological behavior, diagnosis, and treatment alternatives. Feline Oact 1997;24: 5-11.

de Oliveira LO, Rosemari de Oliveira T, Loretti AP, et al . Aspectos epidemiológicos da neoplasia mamária canina. Acta Scientiae Veterinariae 2003;31(2):105-110.

Couto CG, Hammer AS. Oncology (1994). In: Sherding RG. The cat diseases and clinical management. 2.ed. Philadelphia: Saunders p.755-762.

Lamb CR . The canine and feline lung. In: Thrall, D. E. Text book of veterinary diagnostic radiology. 4th. ed. Philadelphia: Saunders.2002; 431-447.

Morris JS, Nixon C, Bruck A, Nasir L, Morgan IM, Philbey AW. Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERAlpha and p53. Vet J 2008;175: 218-226

Castelo-Branco PSM, de Souza SAL, Lopes FPPL, Castro V, Sena P, Pereira JB et al. Uso da 99mTc-Timina na identificação de metástases de tumor venéreo transmissível canino com apresentação cutânea. Pesq Vet Bras 2008;28(8):367-370.

Axiak-Bechtel SM, Maitz CA, Selting KA, Bryan JN. Preclinical imaging and treatment of cancer: the use of animal models beyond rodents. Q J Nucl Med Mol Imaging 2015; 59(3):303-16.

Castelo-Branco PSM, Motta-Silva D, Tancredi MGF,et al. Uso da cintilografia com 99mtc-Timina na avaliação de mesotelioma em cão: relato de caso. Rev de Ci da Vida 2006; 26(Supl.): 391-392.

Peterson ME, Castellano CA, Rishniw M. Evaluation of Body Weight, Body Condition, and Muscle Condition in Cats with Hyperthyroidism, J Vet Intern Med 2016;30(6):1780-1789.

Stock E, Vanderperren K, Bosmans T, et al. Evaluation of Feline Renal Perfusion with Contrast-Enhanced Ultrasonography and Scintigraphy. PLoS ONE 2016; 11(10): e0164488.

Vandermeulen E, Combes A, de Rooster H, et al. Transplenic portal scintigraphy using 99mTc-pertechnetate for the diagnosis of portosystemic shunts in cats: a retrospective review of 12 patients. JFMS 2013;15(12):1123-31.

Schmitz S, Götte B, Borsch C, et al . Direct comparison of solid-phase gastric emptying times assessed by means of a carbon isotope–labeled sodium acetate breath test and technetium Tc 99m albumin colloid radioscintigraphy in healthy cats. Am J Vet Res 2014;75(7):648-52.

Baez JL, Sorenmo KU . Pulmonary and bronchial neoplasia. In:King L. G. Respiratory disease in dogs and cats. Saint Louis: Saunders 2002;.508-515.




DOI: http://dx.doi.org/10.24294/irr.v0i0.596

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License

This site is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.