Brief review of practical epileptology in the field of basic science: Epileptic mutant anilals

Yoshiya L. MURASHIMA

Abstract


Epileptic mutant animals are normally kept in frozen embryo to spare the costs and human powers. However, the seizure thresholds of epileptic mutants are very delicate and the reproducibility of seizure threshold through frozen embryo procedures is unstable.

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References


Serikawa T, Yamada J. Epileptic seizures in rats homozygous for two mutations, zitter and tremor. J Hered 1986;77:441-444.

Sasa M et al. Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat. Epilepsia 1988;29:505-513.

Serikawa T et al. Ontogeny of absence-like and tonic seizures in the spontaneously epileptic rat. Lab Anim 1991;25: 216-221.

Inui T et al. The spontaneously epileptic rat (SER), a zitter tremor double mutant rat: histopathological findings in the central nervous system. Brain Res 1990; 517:123-133.

Avanzini G, Regesta G, Tanganelli P, Avoli M. Current problems in epilepsy 12

Molecular and cellular targets for antiepileptic drugs. 1997; John Libbery Eurotext, Milano :pp100-101.

Murashima YL, Yoshii M. New therapeutic approaches for epilepsies, focusing on reorganization of the GABAA receptor subunits by neurosteroids. Epilepsia 2012; 3:131-134.

Murashima YL, Yoshii M. Specific gene expression before and after seizure in Epileptic EL mice. Encyclopedia of Basic Epilepsy Research 2012; edt. Schwartzkroin P, Academic Press: pp253-258.

Murashima YL et al. Cell cycle re-entry and cell proliferation in the hippocampus of EL mice. Epilepsia 2010; suppl 16:42-56.

Murashima YL et al. Developmental program of epileptogenesis in the brain of EL mice. Epilepsia 2009; 46 suppl 5 :10-16.

Murashima YL et al. Ictogenesis and epileptogenesis in EL mice. Epilepsia 2008; 43:130-135.

Murashima YL, Onose A. Transplantation of pluripotent embryonic stem cells as donor cells to suppress seizures. Hokkaido Epilepsy Res 2013; 32: 5-16.




DOI: http://dx.doi.org/10.63018/nc.v1i1.61

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