Synthesis of Novel Chalcone Derivatives by Organic Catalysis

Junlong Li, Ruocan Zhuang, Yinan Qian

Article ID: 398
Vol 1, Issue 1, 2018

VIEWS - 251 (Abstract) 368 (PDF)

Abstract


Chalcone compounds have a wide range of biological activities. In this paper, nine kinds of novel chalcone compounds were synthesized by using transacrylone derivatives and anthrone as raw materials. The effects of different catalysts and solvents on the yield of the products were investigated. The optimal catalyst was DABCO. The optimum solvent was dichloromethane with the highest yield of 71.6%. On this basis, the effect of the co - catalyst on the yield was investigated. The yield was increased to 89.9%.

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References


1. Zhang ZJ. Therapeutic effects of herbal extracts and const ituents in an -imalmodels of psych iatric d isorders [j]. Life Sci, 2004, 75: 1659.

2. Go M L, Wu X, Liu X L. Chalcones: an update on cytotoxic and chemo protective propert ies [J]. CurrMed Chem, 2005, 12 (4): 481-499.

3. Zheng Hongwei, Niu Xinwen, Zhu Jun and so on. Studies on the biological activity of chalcone compounds [J]. Chinese Journal of New Drugs, 2007,16 (18): 1445-1449.

4. UEDA T, ABLIZ Z, SATO M, et al. Structural determination by MS, NMR, and UV spectra of bromo and nitroderivatives of 1-azabenzanthrone [J]. JM olStruc, 1990, 224: 313-322.

5. Synthesis and Biological Activity of 6- (Alkylhydrazide) -1-Azabenzanthraquinone Derivatives [J]. Chinese Journal of Organic Chemistry, 2012,32 (6) 4): 1-14

6. (B) Melchiorre, P .; Marigo, M .; Carlone, A .; Bartoli, G. Angew. Chem. Int. Edit. [6] (a) MacMillan, DWCNature 2008, 455 (7211), 304-308; . 2008, 47 (33), 6138-6171; (c) Bertelsen, S .; Jorgensen, KA, Chem. Soc. Rev. 2009, 38 (8), 2178-2189.

7. (B) List, B .; Lerner, RA; Barbas (1) (a) Ahrendt, KA; Borths, CJ; MacMillan, DWC, J. Am. Chem. Soc. 2000, 122 (17), 4243-4244; , CF, J. Am. Chem. Soc. 2000, 122 (10), 2395-2396.

8. Anastas, P.T., Chem. Rev. 2007, 107 (6), 2167-2168.

9. Jellerichs, B.G .; Kong, J.-R .; Krische, M.J., J. Am. Chem. Soc. 2003, 125 (26), 7758-7759.

10.

11. Junlong Li, et al

12. (a) Rios, R .; Sundén, H .; Vesely, J .; Zhao, G.-L .; Dziedzic, P .; Córdova, A. Adv. Synt. Catal. 2007, 349 (7 ), 1028-1032;

13. (b)Lu, L.-Q .; Cao, Y.-J .; Liu, X. -P .; An, J .; Yao, C.-J .; Ming, Z. (C) Lu, L.-Q .; Li, F .; An, J, Am. Chem. Soc. 2008, 130 (22), 6946-6948; Zhang, J.-J .; An, X. -L .; Hua, Q. -L .; Xiao, W.-J., Angew. Chem. Int. Edit. 2009, 48 (50), 9542 (5) Lu, L.-Q .; Zhang, J.-J .; Li, F .; Cheng, Y .; An, J .; Chen, J.-R .; Xiao, W.- J., Angew. Chem. Int. Edit. 2010, 49 (26), 4495-4498;

14. (e)Riches, SL; Saha, C .; Filgueira, NFn; Grange, E .; McGarrigle, EM; Aggarwal, VK (Manufactured by J. Am. Chem. Soc. 2010, 132 (22), 7626-7630; (f) Hashimoto, T .; Omote, M .; Maruoka, K., Angew. Chem. Int. Edit. 2011, 15), 3489-3492.

15. (a) Erb, J .; Paull, DH; Dudding, T .; Belding, L .; Lectka, T., J. Am. Chem. Soc. 2011, 133 (19), 7536-7546; B) Kim, HY; Oh, K., Org. Lett. 2011, 13 (6), 1306-1309; (c) Hrdina, R .; Müller, CE; Wende, RC; Lippert, KM; Benassi, M. (50), 7624-7627; (d) Iwata, M .; Yazaki, R .; Chen, IH; Sureshkumar, D., u0026 lt; RTI ID = 0.0 u0026 gt; ; Kumagai, N .; Shibasaki, M., J. Am. Chem. Soc. 2011, 133 (14), 5554-5560; (e) Belot, S .; Vogt, KA; Besnard, C .; Krause, (F) Zhou, S .; Fleischer, S .; Junge, K .; Beller, M., Angew, u0026 lt; RTI ID = 0.0 u0026 gt; Chem. Int. Edit. 2011, 50 (22), 5120-5124.


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