Imaging and Radiation Research


eISSN: 
2578-1618

Journal Abbreviation:

Imaging. Radiat. Res.

Imaging and Radiation Research (IRR, ISSN: 2578-1618) is an international journal dedicated to advancing the field of medical imaging, radiation sciences, and their applications in health and disease.

IRR is open to a broad range of subjects, spanning medical science, surgical practices, biomedical engineering, biology, materials science, environmental science, and related branches of physics and chemistry.

It welcomes original research contributions, including laboratory-based studies, modeling, field tests, case reports, reviews, and significant applications of imaging technology and radiation-related analysis.

The journal covers all aspects of imaging technology and analysis methods, Radiation Biology & Radiation Physics, including but not limited to:

  • The application of SPECT and PET
  • Magnetic resonance imaging (MRI) technologies and advances
  • Ultrasonic imaging
  • Gamma camera and its application
  • Electron microscopy
  • Computed tomography (CT)
  • Electron imaging and processing techniques
  • X-ray diffraction
  • Spectroscopic analysis
  • Radiation detection and measurement
  • Radiotherapy
  • Nuclear physics
  • Ionizing radiation
  • Computer imaging techniques and applications
  • Artificial intelligence and machine learning in imaging
  • Biomedical engineering applications
  • Nanotechnology in imaging and therapy
  • Radiopharmaceuticals and their applications
  • Computational biology in image analysis
  • Environmental radiation monitoring
  • Health policy and management related to imaging and radiation
  • Psychological imaging techniques
  • Personalized medicine based on imaging results
  • Telemedicine and remote diagnostics using imaging technologies

 

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Imaging and Radiation Research is an Open Access Journal under EnPress Publisher. All articles published in Imaging and Radiation Research are accessible electronically from the journal website without commencing any kind of payment. In order to ensure contents are freely available and maintain publishing quality, Article Process Charges (APCs) are applicable to all authors who wish to submit their articles to the journal to cover the cost incurred in processing the manuscripts. Such cost will cover the peer-review, copyediting, typesetting, publishing, content depositing and archiving processes. Those charges are applicable only to authors who have their manuscript successfully accepted after peer-review.

Journal TitleAPCs
Imaging and Radiation Research$300

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Vol 8, No 1 (2025)

Table of Contents

Open Access
Article
Article ID: 11605
PDF
by Qi Xie, Xi-Yan Shao, Yi-Ming Yang, Min-Yi Wu, Jing Zhang
Imaging Radiat. Res. 2025, 8(1);   
Abstract

Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myo-inositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistance-related protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (P < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (P > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (P < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FU-responsive ones at 5-FU concentrations greater than 2.5 μg/mL (P < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.

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For articles submitted to the journal Imaging and Radiation Research that involve human or animal research, authors are required to provide the following documentation based on the specific circumstances:
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